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| 1 | Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats显示文摘AIM To explore the kinetic changes in plasma D (-)lactate and lipopolysaccharide ( LPS ) levels, and investigate whether D (-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/reperfusion, burn, and acute necrotizing pancreatitis (ANP).METHODS Three models were developed in rats:gut ischemia/reperfusion obtained by one hour of superior severe burn injury created by 30% of total body surface induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct.Plasma levels of D( - )-lactate in systemic circulation and LPS in portal circulation were measured by enzymaticspectrophotometric method and limulus amebocyte lysate (LAL) test kit, respectively. Tissue samples of intestine were taken for histological analysis.RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D( - )lactate and LPS levels, and there was a significant correlation between the plasma D( - )-lactate and LPS (r =0.719, P<0.05). The plasma concentrations of D(-)lactate and LPS increased significantly at 6 h postburn,and there was also a remarkable correlation between them (r = 0.877, P < 0.01). D ( - )-lactate and LPS levels elevated significantly at 2 h after ANP, with a similar significant correlation between the two levels (r-0.798,P < 0.01 ). The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups.CONCLUSION The changes of plasma D( - )-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood. The measurement of plasma D (-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. | Xiao-Qing Sun Xiao-Bing Fu Rong-Zhan Yi Lü Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China | 2001 | World Journal of Gastroenterology2001，7，4： | 56 |
| 2 | Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins显示文摘 | Lai TH Fong YC Fu WM | 2008 | Prostate2008，68，12： | 1 |
| 3 | Epidermoid cysts of the testis: diagnosis by ultrasonography and magnetic resonance imaging resulting in organ-preserving surgery显示文摘 | Fu YT Wang HH Yang TH | 1996 | Br J Urol1996，78，1： | 1 |
| 4 | Epidermoid cyst of the testis: diagnosis by ultrasonography and magnetic resonance imaging resulting in organ preserving surgery 显示文摘 | Fu YT Wang HH Yang TH | 1996 | Br J Urol1996，78，1： | 1 |
| 5 | CYP2C9 polymorphism and warf-arin sensitivity in Taiwan Chinese显示文摘 | Chern HD Ueng TH Fu YP | 2006 | Clin Chim Acta2006，367，12： | 1 |
| 6 | Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins显示文摘 | Lai TH Fong YC Fu WM | 2008 | Prostate2008，68，12： | 1 |
| 7 | CYP2C9 poly morphism and warfarin sensitivity in Taiwan Chi nese显示文摘 | Chern HD Ueng TH Fu YP | 2006 | Clin Chim Acta2006，37，12： | 1 |
| 8 | CYP2C9 polymorphism and warfarin sensitivity in Taiwan Chinese显示文摘 | Chem HD Ueng TH Fu YP | 2006 | Clin Chim Acta2006，367，12： | 1 |
| 9 | Induction of CD4^+ T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells显示文摘 | Wang H Fu TH Wang G | 2002 | J Clin Invest2002，109，11： | 1 |
| 10 | Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins 显示文摘 | Lai TH Fong YC Fu WM Yang RS Tang CH | 2008 | Prostate2008，68，12： | 1 |
| 11 | Elevated serum IL-8 is associated with the presence of hepatoeellular carcinoma and independently predicts survival 显示文摘 | Welling TH Fu S Wan S | 2012 | Cancer Invest2012，30，10： | 1 |
| 12 | Elevated serum IL-8 is associat- ed with the presence of hepatocellular carcinoma and independently predicts survival显示文摘 | Welling TH Fu S Wan S | 2012 | Cancer Invest2012，30，10： | 1 |
| 13 | Enhancement of purincrgic signal- ling by excessive endogenous ATP in resiniferatoxin (RTX) neu- ropathy显示文摘 | Lin CL Fu YS Hsiao TH | 2013 | Purinergie Signal2013，9，2： | 1 |
| 14 | 15-Deoxy-Δ(12,14)-prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts显示文摘 | Lin TH Tang CH Wu K Fong YC Yang RS Fu WM | 2011 | J Cell Physiol2011，226，12： | 1 |
| 15 | CYP2C9 polymorphism and warfarin sensitivity in Taiwan Chinese显示文摘 | Chem HD Ueng TH Fu YP | 2006 | Clinica Chimiva Acta2006，367，12： | 1 |
| 16 | CYP2C9 polymorphism and warfarin sensitivity in Taiwan Chinese显示文摘 | Chem HD Ueag TH Fu YP | 2006 | Clin Chim Acta2006，367，： | 1 |
| 17 | Moutan cortex radicis improves lipopolysaccharide-induced acute lung injury in rats through anti-inffammation显示文摘 | Fu PK Yang CY Tsai TH | 2012 | Phytomedicine2012，19，13： | 1 |
| 18 | Anti-Inflammatory and Anticoagulative Effects of Paeonol on LPS-Induced Acute Lung Injury in Rats显示文摘 | Fu PK Wu CL Tsai TH | 2012 | Evidence-Based Complementary and Alternative Medicine2012，2012，83： | 1 |
| 19 | Treatment of displaced intra - articular calcaneal fractures with combined transarticular external fixation and minimal internal fixation 显示文摘 | Fu TH Liu HC Su YS | 2013 | Foot Ankle Int2013，1，： | 1 |
| 20 | CYP2C9 polymorphism and warfarin sensiticity in Taiwan Chinese显示文摘 | Chem HD Ueng TH Fu YP | 2006 | Clin Chim Acta2006，367，： | 1 |
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