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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Interoperability of Design Intent in Integrated Product and Process Design显示文摘Concurrent engineering is currently an overwhelming t rend in product development since it takes the down-stream product development issues and product life-cycle issues into consideration in up-front design pro cess. At this stage, evaluation, verification and validation of design concepts and design schemes is critical to the right-to-market product development. I dentification and extraction of design intent from the part digital mock-ups in different data formats and created in different CAD systems for DFX considerati on, evaluation, verification, and validation is crucial too. Traditionally, fro m manufacturing point of view, feature identification and extraction is to get t he features and feature-related information for manufacturing planning and inte gration. Presently, from the viewpoint of product development and product servi ce life cycle, design intent identification and extraction is to get all the des ign-related information for DFX consideration in early design stage, such as de sign for assembly, design for service, design for tooling, design for functional ity and design for environment etc. Therefore, how to successfully extract desi gn intent such as design and machining features and design-related information from the prototyping digital mock-ups created by different CAD systems for DFX consideration in upstream design stage is a very useful topic in integrated prod uct and process design and development. Presently, there are heterogeneous CAD systems in the market and the interoperat ion among the different CAD systems is indispensable. The interoperability of d ifferent CAD systems is by way of data exchanged technology such as STEP and IGE S. The critical weakness of this interoperation technology is that much of the design intent is lost in the interoperation process. Once the product digital m ock-ups is exchanged via data exchange technology such as IGES or STEP, the des ign intent including the dimension-driven design features and other attributes embedded in the part model are lost in the data translation process. Models rea d out of CAD systems come into other systems as featureless chunks of geometry e ntities. Obviously, the interoperation technology does not satisfy the industry need. It has been reported that this poor interoperation technology, which pro vides poor CAD models in neutral-format geometry had cost the automobile indust ry alone $1 billon per year. Fortunately, some researchers have been aware of t he criticality of this since only the United States industry spends billons of d ollars as a result of poor interoperability between computer-aided engineering software tools. In the past, product development was often done within a single company by co-located design team. In more recent years, there has been a busi ness paradigm shift in product development as the product development is being d one more often by geographically and temporally distributed design teams. There is a high level of outsourcing, not only of manufacturing but also of actual pr oduct development effort. Besides, product development across companies, and ev en within a single company, is often done within a heterogeneous software tool e nvironment. How to improve the interoperability of design intent created in het erogeneous software tool environment geographically has become a critical issue in next-generation product development system. Design intent in this research is defined as the outcome of design process. Des ign process goes from the identification of needs to satisfaction of that needs. Design intent satisfies this kind of needs. In this research, design intent i s created in a CAD system and embedded in part CAD model. The detailed design i ntent here includes design and manufacturing features and the feature-relat ed information such as feature parameters, feature relationships and some relate d characteristics such as associativity. Interoperability refers to the ability to share and communicate in the heterogeneous environment or heterogeneous soft | M W Fu W F Lu A Y C Nee S K Ong | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 2 |
| 3 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 4 | Doping effects of magnesium onthe electrochemical performance of Li2FeSiO4 for lithium ion bat-teries显示文摘 | Zhang S Deng C Fu B L | 2010 | J Electroanal Chem2010，644，2： | 1 |
| 5 | Expression of milk-derived antihypertensive peptide in Escherichia coli 显示文摘 | LV G S HUO G C FU X Y | 2003 | J Dairy Sci2003，86，： | 1 |
| 6 | An Intracellular Protein that Binds Amyloid-beta Peptide and Mediates Neurotoxicity in Alzheimer's Disease显示文摘 | YAN S D FU J SOTO C | 1997 | Nature1997，389，6652： | 1 |
| 7 | Supplementation-time dependence of growth factors in promoting tendon healing显示文摘 | Chan B P Fu S C Qin L | 2006 | Clin Orthop Relat Res2006，448，1： | 1 |
| 8 | The effect of acclima- tion to hypoxia and sustained exercise on subsequent hy- poxia tolerance and swimming performance in goldfish (Carassius auratus)显示文摘 | Fu S J Brauner C J Cao Z D | 2011 | The Journal of Experimental Bi- ology2011，214，12： | 1 |
| 9 | Analyzing the applicability of Dempster's rule to the combination of interval-valued belief structures显示文摘 | Fu C Yang S L | | 0，，04： | 1 |
| 10 | Secretory expression in Escherichia coli and single-step purification of a heat-stable alkaline protease显示文摘 | Fu Z Hamid S B A Razak C A N | | 0，，： | 1 |
| 11 | Characterization of Li2MnSiO4 and Li2FeSiO4 cathode materials synthesized via a citric acid assisted sol-gel method显示文摘 | Deng C Zhang S Fu B L | | 0，，01： | 1 |
| 12 | 14-3-3 proteins:structure,function,and regulation显示文摘 | Fu H Subramanian R R and Masters S C | 2000 | Annu Rev Pharmacol Toxicol2000，40，： | 1 |
| 13 | A Method for real-time compensation of moving ferromagnet′s magnetic moment显示文摘 | Zhou J J Lin C S Fu K | 2013 | Journal of Magnetism and Magnetic Materials2013，325，： | 1 |
| 14 | Responses of trophic groups of soil nematodes to residue application under conventional tillage and no- till regimes 显示文摘 | Fu S L Coleman D C Hendrix P F | 2000 | Soil Biology and Biochemistry2000，32，： | 1 |
| 15 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 16 | Air quality during the 2008 Beijing Olympic Games显示文摘 | STREETS D G FU J S JANG C J | 2007 | Atmospheric Environment2007，41，3： | 1 |
| 17 | Pricing American options: A comparison of MonteCarlo simulation approaches显示文摘 | Fu M C Laprise S B Madan D B Su Y Wu R | 2001 | Journal of Computational Finance2001，4，： | 1 |
| 18 | Identification, characterization, epitope mapping, and three-dimensional modeling of the α-subunit of β-conglycinin of soybean, a potential allergen for young pigs显示文摘 | FU C J JEZ J M KERLEY M S | 2007 | J Agric Food Chem2007，55，10： | 1 |
| 19 | Beneficial effects of enriched environment following status epilepticus in immature rats显示文摘 | FAVERJON S SILVEIRA D C FU D D | 2002 | Neurology2002，59，9： | 1 |
| 20 | Photocatalytic degradation of RhB by fluorinated Bi2WO6 and distributions of the intermediate products显示文摘 | Fu H B Zhang S C Xu T G | 2008 | Environmental Science & Technology2008，42，6： | 1 |
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