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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | A novel XPF-357A 〉 C polymorphism predicts risk and recurrence of bladder cancer(摘要)显示文摘 | Wang, M Yuan, L Wu, D Zhang, Z Yin, C Fu, G Wei, Q | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 5 |
| 3 | Effectof mobile phase composition on the separation of propranolol enantiomers using a perphenylcarbamate β-cyclodextrin bonded chiral stationary phase显示文摘 | CHING C B FU P N G SC | 2000 | J Chromatogr A2000，898，： | 2 |
| 4 | Synthesis of functionalized cyclopentenes through catalytic asymmetric cycloadditions of allenes with enones显示文摘 | Wilson J E Fu G C | 2006 | Angew Chem Int Ed2006，45，： | 1 |
| 5 | Expression of milk-derived antihypertensive peptide in Escherichia coli 显示文摘 | LV G S HUO G C FU X Y | 2003 | J Dairy Sci2003，86，： | 1 |
| 6 | Studies on the synthesis and antibacterial activities of polymeric quaternary ammonium salts from dimethylaminoethyl methacry- late 显示文摘 | Lu G Q Wu D C Fu R W | 2007 | React Funet Polym2007，67，4： | 1 |
| 7 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 8 | Air quality during the 2008 Beijing Olympic Games显示文摘 | STREETS D G FU J S JANG C J | 2007 | Atmospheric Environment2007，41，3： | 1 |
| 9 | Photocatalytic degradation of RhB by fluorinated Bi2WO6 and distributions of the intermediate products显示文摘 | Fu H B Zhang S C Xu T G | 2008 | Environmental Science & Technology2008，42，6： | 1 |
| 10 | Structure organization of silicate polyanions with surfactants: a new approach to the syntheses, structure transformations, and formation mechanisms of mesostructural materials显示文摘 | FYFE C A FU G Y | 1995 | J Am Chem Soc1995，117，38： | 1 |
| 11 | Peculiarities of salt lake sediments as potential source rocks in China显示文摘 | Fu Jiamo Sheng Guoying Peng Pingan Brassell S C Eglinton G Jiang Jigang | 1986 | Org Geochem1986，10，13： | 1 |
| 12 | Air quality during the2008 Beijing Olympic Games显示文摘 | Streets D G Fu J S Ja ng C J | 2007 | Atmospheric Environment2007，41，3： | 1 |
| 13 | Environmental Embrittlement in FeAl Aluminides显示文摘 | Liu C T Fu C L George E P Painter G S | 1991 | ISIJ International1991，31，10： | 1 |
| 14 | Expression of advanced glycation end producls and nendiabetic renal disease 显示文摘 | Tanji N Markowitz G S Fu C | 2000 | J Am Soc Nephrol2000，11，9： | 1 |
| 15 | UAV mobile ground target pur- suit algorithm显示文摘 | Fu X W Feng H C Gao X G | 2012 | Journal of Intelligent & Robotic Systems2012，68，34： | 1 |
| 16 | Natural variation at the DEP1 locus enhances grain yield in rice 显示文摘 | Huang X Qian Q Liu Z Sun H He S Luo D Xia G Chu C Li J Fu X | 2009 | Nature Genetics2009，41，4： | 1 |
| 17 | 查看详情显示文摘 | Liu L Wu C L Zhang J C Zhang M M Liu Y W Wang X J Fu G Q | | 0，，： | 1 |
| 18 | Expreio advanced yeafi end pmd- uc and their oellular RAGE in diabetic nelaathy and nondiahie renal di ease 显示文摘 | Tanji N Markowitz G S Fu C et d | 2000 | Journal of the Aroeean Society of Nelltmloy2000，11，9： | 1 |
| 19 | Hydro-climatic trends of the Yellow River Basin for the last 50 years显示文摘 | Fu G Chen S Liu C | 2004 | Climatic Change2004，65，： | 1 |
| 20 | Some properties of an acidic proteinbound polysaccharide from the fruit of pumpkin显示文摘 | FU C L TIAN H J CAI T G | 2007 | Food Chemistry2007，100，3： | 1 |
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