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| 1 | Magnetic Fe_(2)O_(3)/biochar composite prepared in a molten salt medium for antibiotic removal in water显示文摘The large-scale use of antibiotics is causing serious water pollution problems,and it is of great significance to develop new technologies to remove antibiotics from water.As an environmentally friendly and economical adsorption material,carbon derived from biomass is a low-cost and feasible material for removing antibiotics in sewage,but the current removal efficiencies are not high enough for large-scale practical application.In this study,poplar wood chips are used as raw material,and a magnetic biochar is prepared by co-pyrolysis of poplar wood chips and FeCl_(3)/CaCl_(2)mixed molten salt.X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),N_(2)-isothermal adsorption and desorption,X-ray photoelectron spectroscopy(XPS)and scanning electron microscope(SEM)techniques showed the successful synthesis of Fe_(2)O_(3)/bioC composite.In-situ formed Fe_(2)O_(3)makes the biochar possess the characteristic of superparamagnetic,which is conducive to the recycling of biochar.Due to the etching effect of the molten salts,rough surface was formed on Fe_(2)O_(3)/bioC,result-ing in a maximum norfloxacin(NOR)adsorption ability up to 38.77 mg g^(−1)at pH 6.0.The NOR adsorption behavior on Fe_(2)O_(3)/bioC followed the pseudo second order kinetic model and the equilibrium data was best fitted the Langmuir model.In addition,the adsorption process of NOR on Fe_(2)O_(3)/bioC was thermodynamically spontaneous.The results show that this low-cost and reusable magnetic biochar has the potential for rapid and efficient removal of antibiotic from aqueous solution. | Huagen Liang Chenxi Zhu Shan Ji Palanisamy Kannan Fu Chen | 2022 | Biochar2022，4，1： | 4 |
| 2 | Static coarsening behaviour of lamellar microstructure in selective laser melted Ti–6Al–4V显示文摘Static coarsening mechanism of selective laser melted(SLMed) Ti–6Al–4V with a lamellar microstructure was established at temperatures from 700℃ to 950℃. Microstructure evolution revealed that high heat treatment temperature facilitated martensite decomposition and promoted lamellae growth. At each temperature, the growth rate decreased with increasing holding time. The static coarsening behaviour of SLMed Ti–6Al–4V can be interpreted by Lifshitz, Slyozov, and Wagner(LSW) theory. The coarsening coefficient were 0.33, 0.33–0.4, 0.4–0.5 for 700–800℃, 900℃ and 950℃, respectively. This indicated the coarsening mechanism was bulk diffusion at 700–800℃, and a combination of bulk diffusion and interface reaction at 900℃ and 950℃ conditions. | Sheng Cao Qiaodan Hu Aijun Huang Zhuoer Chen Ming Sun Jiahua Zhang Chenxi Fu Qingbo Jia Chao Voon Samuel Lim Rodney R.Boyer Yi Yang Xinhua Wu | 2019 | Journal of Materials Science & Technology2019，35，8： | 3 |
| 3 | LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity显示文摘Den dritic cells(DCs)play a pivotal role in priming adaptive immunity.However,the in volveme nt of DCs in con trolling excessive and deleterious T cell responses remains poorly defined.Moreover,the metabolic dependenee and regulation of DC function are unclear.Here we show that LKB1 signaling in DCs functions as a brake to restrain excessive tumor-promoting regulatory T cell(Treg)and Th17 cell responses,thereby promoting protective anti-tumor immunity and maintaining proper immune homeostasis.LKB1 deficiency results in dysregulated metabolism and mTOR activation of DCs.Loss of LKB1 also leads to aberrant DC maturation and production of cytokines and immunoregulatory molecules.Blocking mTOR signaling in LKB1-deficient DCs partially rectifies the abno rmal phe no types of DC activation and Treg expansio n,whereas unc on trolled Th17 resp on ses depend upon IL-6-STAT3 signaling.By coordi nating metabolic and immune quiesce nee of DCs,LKB1 acts as a crucial signali ng hub in DCs to enforce protective anti-tumor immunity and normal immune homeostasis. | Yanyan Wang Xingrong Du Jun Wei Lingyun Long Haiyan Tan Cliff Guy Yogesh Dhungana Chenxi Qian Geoffrey Neale Yang-Xin Fu Jiyang Yu Junmin Peng Hongbo Chi | 2019 | Cell Research2019，29，5： | 3 |
| 4 | Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis显示文摘Breast cancer bone metastasis poses significant challenge for therapeutic strategies.Inside the metastatic environment,osteoclasts and tumor cells interact synergistically to promote cancer progression.In this study,the proprotein convertase furin is targeted due to its critical roles in both tumor cell invasion and osteoclast function.Importantly,the furin inhibitor is specifically delivered by bone targeting superparamagnetic iron oxide(SPIO)nanoparticles.Our in vitro and in vivo data demonstrate that this system can effectively inhibit both osteoclastic bone resorption and breast cancer invastion,leading to alleviated osteolysis.Therefore,the bone targeting&furin inhibition nanoparticle system is a promising therapeutic and diagnostic strategy for breast cancer bone metastasis. | Yichuan Pang Li Su Yao Fu Fan Jia Chenxi Zhang Xiankun Cao Wenxin He Xueqian Kong Jiake Xu Jie Zhao An Qin | 2021 | Bioactive Materials2021，6，3： | 2 |
| 5 | Facile synthesis of NiAl_(2)O_(4)/g-C_(3)N_(4) composite for efficient photocatalytic degradation of tetracycline显示文摘Designing high-efficiency photocatalysts responsive to visible light is important for the degradation of antibiotics in water.Heterojunction engineering is undoubtedly an effective strategy to improve the photocatalytic performance.In this work,spinel-type metal oxides(NiAl_(2)O_(4),NAO)are synthesized by a simple sol-gel and calcination process.After compounding graphitic carbon nitride(g-C_(3)N_(4)),NAO/g-C_(3)N_(4) heterojunction is obtained,which then is used as the photocatalyst for tetracycline hydrochloride(TC).The effects of photocatalyst dosage,the initial concentration of TC,and solution pH on photodegradation performance are systematically studied.The removal rate of TC on NAO/g-C_(3)N_(4) reach up to∼90%after visible light irradiation for 2 hr and the degradation rate constant is∼7 times,and∼32 times higher than that of pure NAO and g-C_(3)N_(4).The significantly improved photocatalytic activity can be attributed to the synergistic effect between well matched energy levels in NAO/g-C_(3)N_(4) heterojunctions,improvement of interfacial charge transfer,and enhancement of visible light absorption.This study provides a way for the synthesis of efficient photocatalysts and an economic strategy for removing antibiotics contamination in water. | Huagen Liang Chenxi Zhu Anhu Wang Kannan Palanisamy Fu Chen | 2023 | Journal of Environmental Sciences2023，，5： | 1 |
| 6 | Large scale fabrication of graphene for oil and organic solvent absorption显示文摘A simple method for synthesizing highly wrinkled and less layered structure of graphene sheets by using a mechano-thermal exfoliation method was developed. During this process, graphite and ammonium chloride(NH_4Cl) powders were loaded by milling and followed with heating at a quartz tube under a nitrogen gas flow. The method is facile and easy for scaling up. Consequently, such microstructure merits of structure endowed graphene super strong adsorption ability, which should have great potential for water purification and treatment. | Chenxi Fu Zifeng Wang Junyi Liu Hongbo Jiang Guangming Li Chunyi Zhi | 2016 | Progress in Natural Science:Materials International2016，26，3： | 0 |
| 7 | Development of a molecular feature-based survival prediction model of ovarian cancer using the deep neural network显示文摘Ovarian cancer(OC)is one of the most lethal gynecologic cancer worldwide,and survival prediction is meaningful for personalized treatment.^(1)The survival outcome of cancer patients mainly depended on the malignancy of the primary tumor which is tightly linked with the expression profile of the molecular features.^(2)Therefore,in this study,we developed a molecular feature-based survival prediction model of OC using a deep neural network(DNN). | Tingyuan Lang Muyao Yang Yunqiu Xia Jingshu Liu Yunzhe Li Lingling Yang Chenxi Cui Yunran Hu Yang Luo Dongling Zou Lei Zhou Zhou Fu Qi Zhou | 2023 | Genes & Diseases2023，10，4： | 0 |
| 8 | CsBZIP40 confers resistance against citrus bacterial canker by repressing CsWRKY43-CsPrx53/CsSOD13 cascade mediated ROS scavenging显示文摘As the bacterial etiologic agent causing citrus bacterial canker(CBC),Xanthomonas citri subsp.citri(Xcc)seriously impacts citrus plantation and fruit production globally.In an earlier study,we demonstrated that CsBZIP40 can positively impact CBC resistance in the sweet orange(Citrus sinensis).However,the mechanistic basis for the protective benefits conferred by CsBZIP40 is yet to be delineated.Here,we show that CsBZIP40 positively regulates CBC resistance and reactive oxygen species(ROS)homeostasis in transgenic sweet orange overexpressing CsBZIP40.CsBZIP40 directly binds to the TGA-box of the CsWRKY43 promoter to repress its transcriptional activity.CsWRKY43 overexpression induces CBC susceptibility in transgenic sweet oranges.In contrast,its inhibition produces strong resistance to CBC.CsWRKY43 directly binds to the W-boxes of the CsPrx53 and CsSOD13 promoters to positively regulate the activities of these antioxidant enzymes,resulting in the negative regulation of ROS homeostasis and CBC resistance in sweet orange plants.CsPrx53/CsSOD13 knockdown enhances ROS accumulation and CBC resistance.Overall,our results outline a regulatory pathway through which CsBZIP40 transcriptionally represses CsWRKY43-CsPrx53/CsSOD13 cascade-mediated ROS scavenging in a manner conducive to CBC resistance.These mechanisms underscore the potential importance of CsBZIP40,CsWRKY43,CsPrx53,and CsSOD13,providing promising strategies for the prevention of CBC. | Qiang Li Xiujuan Qin Miao Zhang Qiyuan Yu Ruirui Jia Jie Fan Xin Huang Jia Fu Chenxi Zhang Baohang Xian Wen Yang Qin Long Aihong Peng Lixiao Yao Shanchun Chen Yongrui He | 2023 | Horticulture Research2023，10，8： | 0 |
| 9 | High-throughput screening system of citrus bacterial cankerassociated transcription factors and its application to the regulation of citrus canker resistance显示文摘One of the main diseases that adversely impacts the global citrus industry is citrus bacterial canker(CBC),caused by the bacteria Xanthomonas citri subsp.citri(Xcc).Response to CBC is a complex process,with both proteinDNA as well as protein–protein interactions for the regulatory network.To detect such interactions in CBC resistant regulation,a citrus high-throughput screening system with 203 CBC-inducible transcription factors(TFs),were developed.Screening the upstream regulators of target by yeast-one hybrid(Y1H)methods was also performed.A regulatory module of CBC resistance was identified based on this system.One TF(CsDOF5.8)was explored due to its interactions with the 1-kb promoter fragment of CsPrx25,a resistant gene of CBC involved in reactive oxygen species(ROS)homeostasis regulation.Electrophoretic mobility shift assay(EMSA),dual-LUC assays,as well as transient overexpression of CsDOF5.8,further validated the interactions and transcriptional regulation.The CsDOF5.8–CsPrx25 promoter interaction revealed a complex pathway that governs the regulation of CBC resistance via H2O2homeostasis.The high-throughput Y1H/Y2H screening system could be an efficient tool for studying regulatory pathways or network of CBC resistance regulation.In addition,it could highlight the potential of these candidate genes as targets for efforts to breed CBC-resistant citrus varieties. | Jia Fu Jie Fan Chenxi Zhang Yongyao Fu Baohang Xian Qiyuan Yu Xin Huang Wen Yang Shanchun Chen Yongrui He Qiang Li | 2024 | Journal of Integrative Agriculture2024，23，1： | 0 |
| 10 | Direct pyrolysis to convert biomass to versatile 3D carbon nanotubes/mesoporous carbon architecture:conversion mechanism and electrochemical performance显示文摘The massive conversion of resourceful biomass to carbon nanomaterials not only opens a new avenue to effective and economical disposal of biomass,but provides a possibility to produce highly valued functionalized carbon-based electrodes for energy storage and conversion systems.In this work,biomass is applied to a facile and scalable one-step pyrolysis method to prepare three-dimensional(3D)carbon nanotubes/mesoporous carbon architecture,which uses transition metal inorganic salts and melamine as initial precursors.The role of each employed component is investigated,and the electrochemical performance of the attained product is explored.Each component and precise regulation of their dosage is proven to be the key to successful conversion of biomass to the desired carbon nanomaterials.Owing to the unique 3D architecture and integration of individual merits of carbon nanotubes and mesoporous carbon,the as-synthesized carbon nanotubes/mesoporous carbon hybrid exhibits versatile application toward lithium-ion batteries and Zn-air batteries.Apparently,a significant guidance on effective conversion of biomass to functionalized carbon nanomaterials can be shown by this work. | Chenxi Xu Shunli Li Zhaohui Hou Liming Yang Wenbin Fu Fujia Wang Yafei Kuang Haihui Zhou Liang Chen | 2023 | Frontiers of Chemical Science and Engineering2023，17，6： | 0 |
| 11 | Controllability, Budget Flexibility and New Model of Budgeting System显示文摘 | Fu Chenxi | 2011 | Journal of Modern Accounting and Auditing2011，7，9： | 0 |
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