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| 1 | Molecular organic geochemical evidence for paleoenvironmental changes at 11.87—12.28 m in GS-1 sedimentary core,Gucheng Lake,East China显示文摘Organic lipids with different occurrence modes in a sedimentary core in a subtropicalfreshwater lake, Gucheng Lake, were sequentially extracted, separated and analyzed. Thedown-core variations of OEP index of alkanes, C18:2/C18:0 ratios of fatty acids, ratios of boundfatty acids to free fatty acids, thermo-maturity indices of hopanoid hydrocarbons and relativeconcentrations of sedimentary minerals revealed an evident increasing in allochthonous inputfrom rock detritus below 12.28 m in the sedimentary profile. The distribution pattern of tightly-bound β-hydroxy fatty acids indicated a difference in bacterial communities above and below theboundary, as well as the gammacerane index may assign a significant change in lake watersalinity. The evidence, in general, suggested that a significant paleoenvironmental change hadtaken place in ca. 9.6 kaBP on the regional basis. | Zhang, G Sheng, GY Fu, JM Wang, SM | 1999 | Chinese Science Bulletin1999，44，15： | 15 |
| 2 | 应用Models-3/CMAQ研究长三角区域大气污染及输送显示文摘选用美国国家环保局第3代空气质量模式(Models-3,/CMAQ),配合中尺度气象模式(MM5)进行研究,模拟了2001年1、7月份长江三角洲区域冬夏季典型天气条件下大气层二次污染物臭氧及颗粒物的浓度分布及输送状况。采用2001年冬.夏季各10d的小时监测数据对模式验证。结果表明,Models-3/CMAQ对O3、PM10的模拟相关系数分别为0.77和052;一致性指数分别达到081和0.99。模型对于O3略微低估,标准偏差为-31%,而对于PM10则有所高估,标准偏差为46%。对长三角7月份O3浓度及1月份PM10的模拟结果显示,7月份长三角区域16个主要城市O3日均浓度集中在0.043~0.086mg/m^3之间,其中,泰州、扬州.湖州、镇江O3月日均浓度相对较高,均超过0.064mg/m3o模拟时段内O3最高小时浓度达0.276mg/m^3。1月份整个模拟区域PM10月日均浓度为O056mg/m^3,其中,南京市PM10日均浓度最高,达0.080mg/m^3模拟时段内PM10最高小时浓度达0.432mg/m^3研究表明,长三角地区存在明显的污染物输送现象,大气污染已经从局地污染转化为区域污染。 | 李莉 陈长虹 黄海英 黄成 李作攀 Joshua S Fu Carey J Jang David G Streets | 2007 | 上海环境科学2007，26，4： | 11 |
| 3 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 4 | Patterns of nestin expression in human skin显示文摘 | Wang Y Zhang Y Zeng Y Zheng Y Fu G Cui Z Yang T | 2006 | 中国生物学文摘2006，20，5： | 7 |
| 5 | A novel XPF-357A 〉 C polymorphism predicts risk and recurrence of bladder cancer(摘要)显示文摘 | Wang, M Yuan, L Wu, D Zhang, Z Yin, C Fu, G Wei, Q | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 5 |
| 6 | Fiber gas sensor-integrated smart face mask for roomtemperature distinguishing of target gases显示文摘小、便携式、便宜的便携煤气的传感器在人的健康并且环境监视的即时察觉有大潜在的申请。在这个工作,我们与围单人赛的碳制作了灵活纤维气体传感器 nanotube (SWCNT ) ,多围的碳 nanotube (MWCNT ) ,和 ZnO 量察觉到元素的装饰点的 SWCNT (SWCNTs@ZnO ) 。这些灵活纤维气体传感器能在房间温度被操作与好敏感和恢复时间检测目标气体。他们也展出了优异长期的稳定性,以及好设备机械弯曲能力和坚韧性。把这些灵活煤气的传感器集成到脸面具,制作的便携的聪明的脸面具能被用来有选择地检测 C 2 H 5 哦,由与不同颜色读相应 LEDs 的 HCHO,和 NH 3 。如此的脸面具在新窗户中在事情和便携 electronics.Open | Zhiyi Gao Zhoe n g Lou Shuai Chen La Li Kai Jiang Zuoling Fu Wei Han Guozhen Shen | 2018 | Nano Research2018，11，1： | 3 |
| 7 | Cropping Pattern Modifications Change Water Resource Demands in the Beijing Metropolitan Area显示文摘Adequate freshwater supply has become an issue of increasing local and international concern.Reducing water use in agriculture,which is the largest water using sector of the economy,is both important and urgent.The aim of this paper was to quantify how recent cropping pattern changes have influenced water resources in the great Beijing metropolitan area,an expanding megacity which also includes rural counties.Crop production affects blue water use through water consumption and water pollution,the latter assessed here using a critical dilution method.From 1990 to 2010,the total blue water used by crop production declined due to a decrease in overall cropped area,initially in response to local government policies favouring urban development.However,the average blue water use per hectare increased from 2 112 m3 ha-1 yr-1 in 1990 to 2 764 m3 ha-1 yr-1 in 2003,largely as the result of a transition from cereal to vegetable crops,and in particular an increase in intensively managed plastic and glass covered vegetable production systems.Current policies aim to conserve agricultural land,in the interests of food security,and to stimulate cereal production systems with higher ecosystem services provision.As such,in 2010 the average blue water use was 2 425 m3 ha-1 yr-1.These results demonstrate that cropping pattern changes in peri-urban regions and rural communities surrounding the Beijing metropolitan area can have a substantial impact on water resources.They also highlight the tradeoffs between food production and urban and industrial water supply and the need for integrated policy development. | HUANG Jing Bradley G Ridoutt XU Chang-chun ZHANGHai-lin CHEN Fu | 2012 | Journal of Integrative Agriculture2012，11，11： | 2 |
| 8 | 鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大,以及低盐膳食模式与高血压的患病率和控制率相关显示文摘食物对高血压患病率和控制率的影响尚不清晰。本文旨在中国人群中调查鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大以及低盐膳食模式是否与高血压有关。方法:从2012年9月到2014年12月共招募15303名受试者进行病例对照研究,分为高血压组(n=1604)和正常血压组(n=13660),其中高血压组又分为血压控制亚组(n=397)和血压未控制亚组(n=1207)。收集过去1 年里每周平均鱼、蛋、牛奶、坚果、蔬菜、水果和盐摄入量数据。鱼、蛋、牛奶、坚果、蔬菜、水果和盐的平均摄入量分别为117、150、35、20、2100、300和58g/周。 | Yu G Fu H Huang W Zhang N Deng D Li G Lei H | 2019 | 中华高血压杂志2019，27，5： | 2 |
| 9 | Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance显示文摘 | Ling Yang Ping Li Suneng Fu Ediz S. Calay G?khan S. Hotamisligil | 2010 | Cell Metabolism2010，，6： | 2 |
| 10 | Irreversible adsorption of naphthalene and tetrachlorobiphenyl to Lula and surrogate sediments显示文摘 | Kan A T Fu G Hunter M A | 1997 | Environ Sci Technol1997，31，： | 2 |
| 11 | Effectof mobile phase composition on the separation of propranolol enantiomers using a perphenylcarbamate β-cyclodextrin bonded chiral stationary phase显示文摘 | CHING C B FU P N G SC | 2000 | J Chromatogr A2000，898，： | 2 |
| 12 | The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community 显示文摘 | KONG W D ZHU Y G FU B J | 2006 | Environmental Pollution2006，143，： | 1 |
| 13 | Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture 显示文摘 | FU Z Y LOSI G | 2002 | Neuropharmacology2002，42，3： | 1 |
| 14 | Unique physiological and pathogenic features of Leptospira interrogans revealed by whole genome sequencing显示文摘 | Fu G Jiang XG | 2003 | Nature2003，422，24： | 1 |
| 15 | Irreversible adsorption of naphthalene and tetrachorobiphenyl to lulu and surrogate sediment 显示文摘 | Kan A T Fu G M Hunter M A | 1997 | Environmental Science and Technology1997，31，8： | 1 |
| 16 | Distribution of the C37 tetra-unsaturated alkenone in Lake Qinghai, China: a potential lake salinity inclicator显示文摘 | Liu W G Liu Z H Fu M Y | 2008 | Geochimica et Cosmoehimiea Acta2008，72，： | 1 |
| 17 | Synthesis of functionalized cyclopentenes through catalytic asymmetric cycloadditions of allenes with enones显示文摘 | Wilson J E Fu G C | 2006 | Angew Chem Int Ed2006，45，： | 1 |
| 18 | Modeling the impacts of no till practice on soil erosion and sediment yield with RUSLE, SEDD, and Arcview GIS显示文摘 | Fu G B Chert S L McCool D K | 2006 | Soil and Tillage Research2006，85，： | 1 |
| 19 | Photoelectrochemical property and photocatalytic activity of N-dopod TiO2 nanotube arrays显示文摘 | Xu J J Ao Y H Chen M D Fu D G | 2010 | Applied Surface Science2010，256，13： | 1 |
| 20 | The veterinary antibiotic oxytetracyeline and Cu influence functional diversity of the soil microbial community 显示文摘 | Kong W D Zhu Y G Fu B J | 2006 | Environmental Pollution2006，143，1： | 1 |
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