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	题名	作者	年代	出处	被引量
1	VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab.	Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann	2008	World Journal of Gastroenterology2008，14，26：	15
2	The influence of antiepileptic drugs on cognition : A comparison of levetiracetam with topiramate 显示文摘	Gomer B Wagner K Frings L	2007	Epilepsy Behav2007，10，3：	1
3	The influence of levetiracetam with topiramate 显示文摘	GOMER B WAGNER K FRINGS L	2007	Epilepsy Behav2007，10，3：	1
4	Improved determination of total serum lipids by the sulfo -phospho - vanillin reaction 显示文摘	FRINGS C S FENDLEY T W DUNN R T	1972	Clin Chem1972，18，7：	1
5	A different approach for the ergonomic evaluation of pushing and pulling in practice 显示文摘	KUIJER P HOOZEMANS M J M FRINGS M H W	2007	International Journal of Industrial Ergonomics2007，37，1112：	1
6	Precuneus is involved in allocen- tric spatial location encoding and recognition 显示文摘	Frings L Wagner K Quiske A	2006	Exp Brain Rcs2006，173，4：	1
7	Organic-Inorganic Hybrid Coatings for Coil Coating Application Based on Polyesters and Tetraethoxysilane显示文摘	FRINGS S MEINEMA H A VAN NOSTRUM C F	1998	Progress in Organic Coatings1998，33，4：	1
8	Klebsiella pneu- moniae-triggered DC recruit human NK ceils in a CCRS-dependent manner leading to increased CCL19-responsiveness and activation of NK cells显示文摘	Van Elssen CH Vanderlocht J Frings PW	2010	EurJImmunol2010，40，11：	1
9	Topological design, routing and capacity dimension for ISL network in broadband LEO satellite systems显示文摘	Werner M Frings J Wauquiez F	2001	Satell Commun2001，，19：	1
10	Assessment of simplified methods to measure 18F-FLT uptake changes in EGFR-mutated non-small cell lung cancer patients undergoing EGFR tyrosine kinase inhibitor treatment显示文摘	Frings V Yaqub M Hoyng LL	2014	J Nucl Med2014，55，9：	1
11	Regulation of cyclic nucleotide-gated channels显示文摘	Bradley J Reisert J Frings S	2005	Curr Opin Neurobiol2005，15，3：	1
12	Improved determination of total serum lipids by the sulfo-phosphovanillin reaction显示文摘	Frings C S Fendley T W Dunn R T	1972	Clinical Chemistry1972，18，7：	1
13	Differential effect of side of temporal lobe epilepsy on lateralization of hippocampal, temporolateral, and inferior frontal activation patterns during a verbal episodic memory task显示文摘	WAGNER K FRINGS L SPREER J	2008	Epilepsy Behay2008，12，：	1
14	Permeation and activation of the M2 ion channel of influenza Avirus显示文摘	Mould J A Drury J E Frings SM	2000	The Journal of biological chemistry2000，275，31：	1
15	Interventional lung assist enables lung protective mechanical ventilation in acute respiratory distress syndrome 显示文摘	Nierhaus A Frings D Braune S	2011	Minerva Anestesiol2011，77，8：	1
16	Enantioselective nitrene transfer to sulfides catalyzed by a chiral iron complex显示文摘	Wang J Frings M Bolm C	2013	Angew Chem Int Ed2013，52，33：	1
17	Repeatability of metabolically active tumor volume measurements with FDG PET/ CT in advanced gastrointestinal malignancies:a multicenter study 显示文摘	Frings V van Velden FH Velasquez LM	2014	Radiology2014，273，2：	1
18	Cerebellar involvement in verb generation: An fMRI study显示文摘	Markus Frings Albena Dimitrova Christoph F. Schorn Hans-Gerd Elles Christoph Hein-Kropp Elke R. Gizewski Hans Christoph Diener Dagmar Timmann	2006	Neuroscience Letters2006，，1：	1
19	Topological design,routing and capacity dimension for ISI network in broad band LEO satellite systems 显示文摘	WERNER M FRINGS J WAUQUIEZ F	2001	Satell Commun2001，，19：	1
20	Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma显示文摘	Jungraithmayr W Frings C Zissel G	2008	Respirology2008，13，7：	1

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