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| 1 | Oncogenic driver mutations in non-small cell lung cancer: Past, present and future显示文摘Lung cancer,of which non-small lung cancer is the most common subtype,represents the leading cause of cancer related-death worldwide.It is now recognized that a significant proportion of these patients present alterations in certain genes that drive oncogenesis.In recent years,more of these so-called oncogenic drivers have been identified,and a better understanding of their biology has allowed the development new targeted agents.This review aims to provide an update about the current landscape of driver mutation in non-smallcell lung cancer.Alterations in Kirsten rat sarcoma,epidermal growth factor receptor,MET,anaplastic lymphoma kinase,c-ROS oncogene 1,v-raf murine sarcoma viral oncogene homolog B,neurotrophic receptor tyrosine kinase,human epidermal growth factor 2,neuregulin-1 and rearranged during transfection are discussed,as well as agents targeting these alterations.Current standards of treatment as well as promising future strategies are presented.Currently,more than fifteen targeted agents are food and Drug administration-approved for seven oncogenic drivers in non-small-cell lung cancer,highlighting the importance of actively searching for these mutations.Continuous and future efforts made in defining the biology of each of these alterations will help to elucidate their respective resistance mechanisms,and to define the best treatment strategy and therapeutic sequence. | Mathieu Chevallier Maxime Borgeaud Alfredo Addeo Alex Friedlaender | 2021 | World Journal of Clinical Oncology2021，12，4： | 4 |
| 2 | Bone aUografts: the biological consequences of immunological events显示文摘 | Friedlaender GE | 1991 | J Bone Joint Surg Am1991，73，8： | 1 |
| 3 | Malignant bone tumors:limb sparing versus amputation显示文摘 | DiCaprio MR Friedlaender GE | 2003 | Orthop Surg2003，11，1： | 1 |
| 4 | Development of high-gradient and open-gradient magnet separation of dry fine coal 显示文摘 | Hise E C Holman A S Friedlaender F J | 1981 | IEEE Transactions on Magnetics1981，17，6： | 1 |
| 5 | Biomechanical properlies of bone allografts 显示文摘 | Pelkcr RR Friedlaender GE Markham TC | 1983 | Clin Orthop1983，，174： | 1 |
| 6 | Chromo-somal rearrangements in lipofibromatosis 显示文摘 | Kenney B Richkind K E Friedlaender G Zambrano E | 2007 | Cancer Genet Cyto-genet2007，179，2： | 1 |
| 7 | Effects of topically applied ocular decongestant and anti- histamine显示文摘 | Abelson MB Allansmith MR Friedlaender MH | 1980 | Am J Ophthalmol1980，90，： | 1 |
| 8 | Market Structure and Multiproduct Industries 显示文摘 | Bailey Elizabeth E Friedlaender Ann F | 1982 | Journal of Economic Literature1982，，3： | 1 |
| 9 | Osteogenic protein - 1 (bone morphogenetic protein-7) in the treatment of tibial nonu- nions 显示文摘 | Friedlaender GE Perry ER CoIe ID | 2001 | J Bone Joint Surg Am2001，83，： | 1 |
| 10 | Effects of topically applied ocular decongestant and anti-histamine显示文摘 | Abelson MB Allansmith MR Friedlaender MH | 1980 | Am J Ophthalmol1980，90，2： | 1 |
| 11 | Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions显示文摘 | Perry CR Cole JD | 2001 | J Bone Joint Surg Am2001，83，1： | 1 |
| 12 | LASIK surgery using the IntraLase femtosecond laser显示文摘 | Friedlaender MH | 2005 | Int Ophthalmol C1in2005，45，3： | 1 |
| 13 | Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions显示文摘 | Perry CR Cole JD | 2001 | J Bone Joint Surg Am2001，831，2： | 1 |
| 14 | Indirect Taxes and Relative Prices显示文摘 | Friedlaender | 1967 | The Quarterly Journal of Economics1967，81，1： | 1 |
| 15 | The genetic structure and history of Africans and African Americans显示文摘 | Tishkoff S A Reed F A Friedlaender F R | 2009 | Science2009，324，： | 1 |
| 16 | LASIK surgery using the IntraLase femtosecond laser 显示文摘 | Friedlaender MH | 2006 | Int Ophthalmol Clin2006，46，： | 1 |
| 17 | The transition region and coronal explorer显示文摘 | B.N. Handy L.W. Acton C.C. Kankelborg C.J. Wolfson D.J. Akin M.E. Bruner R. Caravalho R.C. Catura R. Chevalier D.W. Duncan C.G. Edwards C.N. Feinstein S.L. Freeland F.M. Friedlaender C.H. Hoffmann N.E. Hurlburt B.K. Jurcevich N.L. Katz G.A. Kelly J.R. Lem | 1999 | Solar Physics1999，，2： | 1 |
| 18 | Induction of specific T-cell responsiveness to allogeneic bone显示文摘 | Friedlaender GE | 1991 | J Bone Joint Surg1991，73，8： | 1 |
| 19 | OP-1 clinical studies 显示文摘 | Friedlaender GE | 2001 | J Bone Joint Surg Am2001，831，2： | 1 |
| 20 | Fine particle processing by magneticcarrier methods显示文摘 | Liu Q X Friedlaender F J | | 0，，04： | 1 |
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