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| 1 | 蚯蚓(Eiseniafetida)细胞色素P450及抗氧化酶系对环境浓度苯并(a)芘的响应显示文摘以赤子爱胜蚓(Eisenia fetida)为供试生物,草甸棕壤为供试土壤,以蚯蚓微粒体细胞色素P450含量、抗氧化酶系以及谷胱甘肽转移酶活性为指标,进行了土壤中苯并(a)芘[B(a)P]暴露与酶活性的量-效关系研究。结果表明,在接近沈抚灌区实地污染状况B(a)P(0.1~2.0mg.kg-1)暴露下,第1、3、7以及第14d取样时,P450和SOD有较好的响应:SOD在第1、3d显著升高,而在第7、14d时降低;P450总体表现为低浓度B(a)P诱导下降低,高浓度下升高的趋势。CAT、POD以及GST的敏感性相对较差。比照其他4个指标,蚯蚓P450的敏感性更为优异,具有较好的应用前景。指标敏感性总体表现为:P450>SOD>CAT/POD>GST。 | 王磊 宋玉芳 张薇 陈朗 David Freestone M Leigh Ackland | 2009 | 农业环境科学学报2009,28,2: | 12 |
| 2 | 植物CytP450和抗氧化酶对土壤菲、芘暴露的生态毒理响应显示文摘以玉米(ZeamaysL.)为供试植物,草甸棕壤为供试土壤,以微粒体细胞色素P450含量、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和过氧化物酶(POD)活性为指标,进行了土壤菲、芘暴露的生态毒理响应研究.结果表明,菲、芘暴露均能引起植物代谢解毒和抗氧化防御系统的胁迫响应,不同程度引发植物代谢解毒及抗氧化能力的改变.P450酶活性与低浓度菲、芘单一暴露浓度具有相关性(r=0.834,p<0.01),与菲、芘复合暴露浓度负相关,说明菲、芘复合暴露导致代谢解毒能力下降,对植物的代谢解毒具有协同毒性效应;SOD酶活性与菲、芘单一暴露浓度负相关,CAT酶活性与菲、芘单一暴露浓度正相关,POD酶活性与菲的水溶解度正相关,而与芘的总浓度负相关.SOD、CAT和POD酶活性与菲、芘复合暴露浓度均呈正相关,说明菲、芘复合暴露导致氧化损伤程度减弱,对植物的氧化损伤具有拮抗作用. | 宋玉芳 王磊 李昕馨 张薇 陈朗 Freestone David 吉普辉 Ackland M Leigh | 2009 | 环境科学学报2009,29,2: | 9 |
| 3 | 植物CytP450和抗氧化酶对土壤低浓度菲、芘胁迫的响应显示文摘以小麦(Triticum acstivnm)为供试植物,草甸棕壤为供试土壤,以微粒体细胞色素P450及抗氧化酶SOD、POD和CAT酶活性为指标,进行了土壤中菲、芘单一及复合胁迫响应研究。结果初步表明,菲、芘胁迫引起植物体内解毒代谢和抗氧化防御酶反应。菲、芘单一胁迫浓度为1mgkg-1时对细胞色素P450产生显著诱导;4mgkg-1时P450酶含量明显被抑制,表明低浓度菲、芘单一胁迫对植物代谢解毒系统产生损伤;而菲、芘复合1mgkg-1时P450酶含量明显被抑制,说明菲、芘复合胁迫对植物的代谢解毒具有协同毒性效应。土壤中菲、芘单一胁迫未引起SOD酶活性的明显改变,复合胁迫下SOD酶活性出现微弱下降;菲、芘单一胁迫对CAT和POD酶活性具有显著抑制作用;复合胁迫对CAT产生抑制作用,而POD酶活性并未对菲、芘复合产生增强毒性响应。研究从代谢解毒和抗氧化防御酶系统两方面,为土壤低浓度PAHs污染诊断提供了实验依据。 | 宋玉芳 李昕馨 张薇 David Freestone M.Leigh Ackland 陈朗 吉普辉 杨晓霞 | 2009 | 生态学报2009,29,7: | 6 |
| 4 | 张家川马家塬战国墓地出土玻璃与相关材料研究显示文摘张家川马家塬战国墓地自2006年发掘以来,出土遗物中玻璃与玻璃质材料(vitreous materials)[1]占相当大的比例,后者包括汉蓝、汉紫、铅白、釉陶等。它们多以不同形态的串珠或镶嵌作为墓主身体及随葬车马的装饰,虽然未作精确统计,但有些墓葬中出土的串珠便以万计,足见用量之大。 | 林怡娴 周广济 Ian Freestone Thilo Rehren | 2018 | 文物2018,,3: | 6 |
| 5 | Endothelial Dysfunction and Damage in Congestive Heart Failure: Relation of Flow-Mediated Dilation to Circulating Endothelial Cells, Plasma Indexes of Endothelial Damage, and Brain Natriuretic Peptide显示文摘 | Aun Yeong Chong Andrew D. Blann Jeetesh Patel Bethan Freestone Elizabeth Hughes Gregory Y.H. Lip | 2004 | Circulation2004,,13: | 2 |
| 6 | Realising new leisure opportunities for old urban parks: the internal reserve in Australia 显示文摘 | Freestone R Nichols D | 2004 | Landscape and Urban Planning2004,68,1: | 1 |
| 7 | Metabolic modulation with perhexiline in chronic heart failure - a randomized, controlled trim of short - term use of a novel treatment 显示文摘 | Lee L Campbell R Scheuermann - Freestone M et al | 2005 | Circulation2005,112,: | 1 |
| 8 | Ankylosing spondylitis,HLA-B27 positivity and the need for biologie therapies显示文摘 | Freeston J Barkham N Hensor E | | 0,,: | 1 |
| 9 | Non-nvasive magnetic stimulation of human motor cortex显示文摘 | Barker AT Jalinous R Freeston IL | | 0,,8437: | 1 |
| 10 | Imaging spatial distributions of resistivity using applied potential tomography显示文摘 | Barber C C Brown B H Freeston I L | 1983 | Electronics Letters1983,19,22: | 1 |
| 11 | Imaging spatial distributions of resistivity using applied potential tomography显示文摘 | BARBER C C BROWN B H FREESTON I L | 1983 | Electronics Letters1983,19,22: | 1 |
| 12 | Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm 显示文摘 | Freestone T Turner RJ Coady A | 1995 | Arterioscler Thromb Vasc Biol1995,15,: | 1 |
| 13 | Noninvasive magnetic stimuIntion of the human nmtor cortex 显示文摘 | Barker AT Jalinmm R Freeston IL | 1985 | Lancet1985,1,8437: | 1 |
| 14 | Soluble CD40 ligand and atrial fibrillation:relationship to platelet activation,and endothelial damage/dysfunction显示文摘 | Blann AD Choudhury A Freestone B | 2008 | Int J Cardiol2008,127,1: | 1 |
| 15 | A diagnostic algo- rithmfor persistence of very early inflammatory arthritis : the utility of powerDoppler ultrasound when added to conventional assessment tools 显示文摘 | Freeston JE Wakefield R J Conaghan PG | 2010 | AnnRheum Dis2010,69,2: | 1 |
| 16 | Magnetic stimulation of the human brain and peripheral nervous system: an introduction and the results of an initial clinical evaluation显示文摘 | Barker A T Freeston I L Jalinous R | 1987 | Neurosurgery1987,20,1: | 1 |
| 17 | Realising new leisure opportunities for old urban parks: The internal reserve in Australia 显示文摘 | Freestone R | 2004 | Landscape and Urban Planning2004,68,1: | 1 |
| 18 | Inflam mation and matrix metalloproteinases in the enlarging abdomi nal aortic aneurysm显示文摘 | FREESTONE T TURNER R J COADY A | 1995 | Arterioscler Thromb Vasc Biol1995,15,8: | 1 |
| 19 | A new model of congestive heart failure in the mouse due to chron-ic volume overload 显示文摘 | Scheuermann-Freestone M Freestone N S Langenickel T | 2001 | EurJ Heart Fail2001,3,5: | 1 |
| 20 | Non-invasive simulation of the human motor cortex显示文摘 | Barker AT Jalinous R Freeston IL | 1985 | The Lancet1985,1,8437: | 1 |