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| 1 | Portal vein thrombosis in cirrhosis: Controversies and latest developments显示文摘Portal vein thrombosis(PVT) is encountered in livercirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication.We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation,and management. Studies were identified by a search strategy using MEDLINE and Google Scholar. The incidence of PVT increases with increasing severity of liver disease: less than 1% in well-compensated cirrhosis, 7.4%-16% in advanced cirrhosis. Prevalence in patients undergoing liver transplantation is 5%-16%.PVT frequently regresses instead of uniform thrombus progression. PVT is not associated with increased risk of mortality. Optimal management has not been addressed in any consensus publication. We propose areas for future research to address unresolved clinical questions. | Damian J Harding M Thamara PR Perera Frederick Chen Simon Olliff Dhiraj Tripathi | 2015 | World Journal of Gastroenterology2015，21，22： | 42 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 4 | 食用菌主要病原真菌和细菌显示文摘食用菌已成为我国农业产业中的第五大作物。随着食用菌生产规模的扩大,病害日益严重,成为影响食用菌产量和品质的重要因素之一。本文概述了引起食用菌主要病害的病原真菌和细菌的种类、寄主范围、病害发生率以及发病症状,阐明了食用菌病害防治研究现状。同时也总结了一些病害的防治方法,为食用菌栽培、病害防治和抗病育种提供理论依据。 | 刘正慧 李丹 SOSSAH Frederick Leo 沈宏艳 OKORLEY Benjamin Azu 付永平 | 2018 | 菌物研究2018，16，3： | 30 |
| 5 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 6 | 华南与美国西部间下、中寒武统界线对比显示文摘根据三叶虫Bathynotus,Microryctocara ,Pagetiaprolata和Oryctocephalusindicus在华南和美国西部地层上相同或相类似的分布 ,对冈瓦纳与劳伦古陆下、中寒武统界线进行对比 ,并将Oryctocephalusindicus一种的首次出现作为确定两大古陆中寒武统的底界 ,而推荐此种作为界线层型中寒武统的标准种。 | Frederick A.Sundberg 袁金良 Linda B.McCollum 赵元龙 | 1999 | 古生物学报1999，38，S1： | 19 |
| 7 | 肠缺血再灌流时肠内给予葡萄糖能增加肠黏膜血流量显示文摘目的 探讨肠缺血再灌流损伤时肠内营养与肠黏膜血流改变的关系。 方法 SD大鼠随机分为丙氨酸组 (12只 )、葡萄糖组 (14只 )和甘露醇对照组 (10只 )。先制作空肠袋 ,将激光多谱勒探头和肠黏膜张力计放置在空肠袋两端 ,分别向袋内注入丙氨酸、葡萄糖和甘露醇。用动脉夹阻断肠系膜上动脉血流 6 0min后 ,再恢复灌流 6 0min。每 30min分别测定肠黏膜血流量和局部PCO2 张力 (PrCO2 )。 结果 缺血再灌流过程中 ,与甘露醇组比较 ,葡萄糖组肠黏膜血流量显著增加 ,PrCO2降低 ,P <0 0 1。 结论 缺血再灌流过程中 ,肠内给予葡萄糖能增加肠黏膜血流量 。 | 胡森 Rosemary A.Kozar Frederick A.Moore 盛志勇 | 2001 | 中华烧伤杂志2001，17，3： | 17 |
| 8 | 大力推行能效电厂,支持实现国家节能减排目标显示文摘'能效电厂'可有效提高终端用电效率,支持中国实现'十一五'节能减排目标。提出了从电价中回收成本、系统效益收费等4种财务上可行的能效电厂实施模式,并进行了比较分析;探讨了地方政策改革对支持和实施能效电厂的重要性和可行性;就国家层面如何支持能效电厂实施,从立法、资金来源、市场参与等方面提出了建议。 | David Moskovitz Frederick Weston 周伏秋 郁聪 胡兆光 刘树杰 林江 | 2007 | 电力需求侧管理2007，9，4： | 15 |
| 9 | Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo显示文摘OBJECTIVE: Little effort has been made to study the protein-encoding genes isolated from traditional Chinese medicine(TCM) drugs, and the delivery of these genes into malignant cells through recombinant adeno-associated virus(r AAV) vectors has not been attempted. METHODS: We synthesized the c DNAs of five known cytotoxic proteins isolated from TCM drugs and the FLAG epitope-tagged c DNAs were subcloned into a r AAV plasmid vector. The protein expression was confi rmed by Western blot assay. Various cancer cell lines were transfected with the above plasmids and cell growth was monitored both in vitro and in vivo. The best cytotoxic gene was further packaged into r AAV vectors, under the control of a liver cancer-specifi c promoter. The liver tumor growth was then monitored following intratumor administration of the r AAV vectors.RESULTS: The expression plasmids, encoding individual potential cytotoxic genes tagged with FLAG epitope, were successfully generated and sequenced. Among these genes, trichosanthin(TCS) gene yielded the most promising results for the inhibition of cancer cell growth in vitro. The over-expressed TCS functioned as a type I ribosome-inactivating protein, followed by inducing apoptosis that is associated with the Bcl-PARP signaling pathway. Furthermore, intratumor injection of r AAV vectors containing the TCS gene signifi cantly inhibited the growth of human hepatocellular carcinoma tumors in a murine xenograft model.CONCLUSION: Our studies suggest that the use of TCM cytotoxic genes is a useful therapeutic strategy for treating human cancers in general, and liver tumors in particular. | Yuan-hui Zhang Yuan Wang Ali Hussein Yusufali Frederick Ashby Daniel Zhang Zi-fei Yin George V.Aslanidi Arun Srivastava Chang-quan Ling Chen Ling | 2014 | Journal of Integrative Medicine2014，12，6： | 14 |
| 10 | Two Divergent Members of 4-Coumarate: Coenzyme A Ligase from Salvia miltiorrhiza Bunge: cDNA Cloning and Functional Study显示文摘4-Coumarate:辅酶 A ligase (4CL ) 是在导致 phenolics 的系列的 phenylpropanoid 新陈代谢的关键酶之一,包括水溶性的酉分的酸,它是决定 Danshen (鼠尾草植物 miltiorrhiza Bunge ) 的药用的质量的重要混合物,繁体中文药用的植物。在 Danshen 在水溶性的酉分的酸的生合成调查 4CL 的功能,我们克隆由使用嵌套的反向的抄写聚合酶链反应( RT-PCR ),退化教材由 cDNA 的快速的扩大结束的 5/3 (种族)列在后面编码分叉的 4CL 成员的二 cDNAs ( Sm4CL1 和 Sm4CL2 )(笔记,这些顺序数据在就职数字 AY237163 和 AY237164 下面被提交了到 GenBank 数据库)。编码,区域被插入到 pRSET 向量,运动试金与净化的 recombinant 蛋白质被执行。Sm4CL1 的底层利用侧面从 Sm4CL2 的是不同的。到 4-coumaric 酸的 Sm4CL1 和 Sm4CL2 的 Km 价值是(72.20 獥敳 ? 楷桴吗? | Shu-Juan Zhao Zhi-Bi Hu DI Liu Frederick C. C. Leungt | 2006 | Journal of Integrative Plant Biology2006，48，11： | 13 |
| 11 | Activation of Defense Response Pathways by OGs and Fig22 Elicitors in Arabidopsis Seedlings显示文摘 | Carine Denoux Roberta Galletti Nicole Mammarella Suresh Gopalan Danièle Werck Giulia De Lorenzo Simone Ferrari Frederick M. Ausubel Julia Dewdney | 2008 | Molecular Plant2008，1，3： | 13 |
| 12 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 13 | TRPM2: a candidate therapeutic target for treating neurological diseases显示文摘短暂受体潜力 melastatin (TRPM2 ) 2 是钙(Ca 2+)-permeable 属于 TRP 离子隧道家庭的非选择的阳离子隧道。氧化导致压力的 TRPM2 激活在许多房间类型挑起异常细胞内部的 Ca 2+ 累积和房间死亡,包括神经原。异常 TRPM2 功能包括局部缺血 / 击, Alzheimers 疾病,神经病的疼痛, Parkinsons 疾病和双极的混乱在几神经病学的混乱被含有。除了在疾病为 TRPM2 识别一个角色的研究,进步在大脑在 TRPM2 的生理的功能的鉴定被取得了,包括 TRPM2 为 N-methyl-D-aspartate ( NMDA )受体依赖者的正式就职是必要的最近的证据长期的消沉,在 glutamate 触处的 synaptic 粘性的一种重要形式。这里,我们处于健康和疾病在中央神经系统(CNS ) 在 TRPM2 的角色上总结最近的证据并且讨论指向 TRPM2 的潜在的治疗学的含意。一起,这些研究建议 TRPM2 为神经病学的混乱代表一个未来的新奇治疗学的目标。 | Jillian Corinne BELROSE Michael Frederick JACKSON | 2018 | Acta Pharmacologica Sinica2018，39，5： | 12 |
| 14 | A method for the production and expedient screening of CRISPR/Cas9-mediated non-transgenic mutant plants显示文摘Developing CRISPR/Cas9-mediated non-transgenic mutants in asexually propagated perennial crop plants is challenging but highly desirable.Here,we report a highly useful method using an Agrobacterium-mediated transient CRISPR/Cas9 gene expression system to create non-transgenic mutant plants without the need for sexual segregation.We have also developed a rapid,cost-effective,and high-throughput mutant screening protocol based on Illumina sequencing followed by high-resolution melting(HRM)analysis.Using tetraploid tobacco as a model species and the phytoene desaturase(PDS)gene as a target,we successfully created and expediently identified mutant plants,which were verified as tetra-allelic mutants.We produced pds mutant shoots at a rate of 47.5%from tobacco leaf explants,without the use of antibiotic selection.Among these pds plants,17.2%were confirmed to be non-transgenic,for an overall non-transgenic mutation rate of 8.2%.Our method is reliable and effective in creating non-transgenic mutant plants without the need to segregate out transgenes through sexual reproduction.This method should be applicable to many economically important,heterozygous,perennial crop species that are more difficult to regenerate. | Longzheng Chen Wei Li Lorenzo Katin-Grazzini Jing Ding Xianbin Gu Yanjun Li Tingting Gu Ren Wang Xinchun Lin Ziniu Deng Richard J.McAvoy Frederick G.Gmitter Jr. Zhanao Deng Yunde Zhao Yi Li | 2018 | Horticulture Research2018，5，1： | 12 |
| 15 | Recent progress in CFD for naval architecture and ocean engineering显示文摘An overview is provided of CFDShip-Iowa modeling, numerical methods and high performance computing(HPC), including both current V4.5 and V5.5 and next generation V6. Examples for naval architecture highlight capability and needs. High fidelity V6 simulations for ocean engineering and fundamental physics describe increased resolution for analysis of physics of fluids. Uncertainty quantification research is overviewed as the first step towards development stochastic optimization. | STERN Frederick WANG Zhaoyuan YANG Jianming SADAT-HOSSEINI Hamid MOUSAVIRAAD Maysam BHUSHAN Shanti DIEZ Matteo YOON Sung-Hwan WU Ping-Chen YEON Seong Mo DOGAN Timur KIM Dong-Hwan VOLPI Silvia CONGER Michael MICHAEL Thad XING Tao THODAL Robert S. GRENESTEDT Joachim L. | 2015 | Journal of Hydrodynamics2015，27，1： | 12 |
| 16 | Effects of live yeast on differential genetic and functional attributes of rumen microbiota in beef cattle显示文摘Several studies have evaluated the effects of live yeast supplementation on rumen microbial population;however,its effect on differential microbial genes and their functional potential has not been described. Thus, this study applied shotgun metagenomic sequencing to evaluate the effects of live yeast supplementation on genetic and functional potential of the rumen microbiota in beef cattle. Eight rumen-cannulated Holstein steers were randomly assigned to two treatments in a cross-over design with two 25-day experimental periods and a 10-day wash-out between the two periods. The steers were housed in individual pens and fed 50% concentrate-mix and 50% red clover/orchard hay ad libitum. Treatments were(1) control(CON;basal diet without additive) and(2) yeast(YEA;basal diet plus 15 g/d of live yeast product). Rumen fluid samples were collected at 3, 6, and 9 h after feeding on the last d of each period. Sequencing was done on an Illumina Hi Seq 2500 platform. Dietary yeast supplementation increased the relative abundance of carbohydrate-fermenting bacteria(such as Ruminococcus albus, R.champanellensis, R. bromii, and R. obeum) and lactate-utilizing bacteria(such as Megasphaera elsdenii, Desulfovibrio desulfuricans, and D. vulgaris). A total of 154 differentially abundant genes(DEGs) were obtained(false discovery rate < 0.01). Kyoto Encyclopedia of Genes and Genomes(KEGG) annotation analysis of the DEGs revealed that 10 pathways, including amino sugar and nucleotide sugar metabolism, oxidative phosphorylation, lipopolysaccharide biosynthesis, pantothenate and coenzyme A biosynthesis, glutathione metabolism, beta-alanine metabolism,polyketide sugar unit biosynthesis, protein export, ribosome, and bacterial secretory system, were enriched in steers fed YEA. Annotation analysis of the DEGs in the carbohydrate-active enzymes(CAZy) database revealed that the abundance of genes coding for enzymes belonging to glycoside hydrolases, glycosyltransferases, and carbohydrate binding modules were enriched in steers fed YEA. These results confirm the effectiveness of a live S. cerevisiae product for improving rumen function in beef steers by increasing the abundance of cellulolytic bacteria, lactic acid-utilizing bacteria, and carbohydrate-active enzymes in the rumen. | Ibukun M.Ogunade Jerusha Lay Kenneth Andries Christina J.Mc Manus Frederick Bebe | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 11 |
| 17 | 基于PFC2D的砂土原生各向异性微观机理数值试验显示文摘采用颗粒流PFC数值模拟方法,生成符合标准砂室内单元试验结果的离散元数值试验试样。运用重力沉积法建立不规则砂土颗粒单元的平面双轴试验模型,给定不同沉积步数对试样不同初始原生状态进行模拟,然后分别从水平和竖直方向上施加荷载增量,得到不同沉积条件下不同加载方向上砂土试样宏观应力应变曲线和力学参数。数值试验结果显示,重力沉积步数对颗粒微观长轴定向排列、平均配位数有显著影响;初步建立了砂土微观结构变化和宏观应力应变曲线及力学参数的联系;分析了砂土试样表现出的宏观原生各向异性力学特性与内部颗粒结构的关系。 | 张坤勇 李威 罗兴军 CHARKLEY Nai Frederick | 2017 | 岩土工程学报2017，39，3： | 10 |
| 18 | Autonomy in materials research: a case study in carbon nanotube growth显示文摘Advances in materials are an important contributor to our technological progress,and yet the process of materials discovery and development itself is slow.Our current research process is human-centred,where human researchers design,conduct,analyse and interpret experiments,and then decide what to do next.We have built an Autonomous Research System(ARES)—an autonomous research robot capable of first-of-its-kind closed-loop iterative materials experimentation.ARES exploits advances in autonomous robotics,artificial intelligence,data sciences,and high-throughput and in situ techniques,and is able to design,execute and analyse its own experiments orders of magnitude faster than current research methods.We applied ARES to study the synthesis of singlewalled carbon nanotubes,and show that it successfully learned to grow them at targeted growth rates.ARES has broad implications for the future roles of humans and autonomous research robots,and for human-machine partnering.We believe autonomous research robots like ARES constitute a disruptive advance in our ability to understand and develop complex materials at an unprecedented rate. | Pavel Nikolaev Daylond Hooper Frederick Webber Rahul Rao Kevin Decker Michael Krein Jason Poleski Rick Barto Benji Maruyama | 2016 | npj Computational Materials2016，，1： | 9 |
| 19 | Probiotics for the treatment of Helicobacter pylori infection in children显示文摘The combination of a proton pump inhibitor and two antibiotics(clarithromycin plus amoxicillin or metronidazole)has been the recommended first-line therapy since the first guidelines for Helicobacter pylori(H.pylori)infection in children were published.In recent years,the success of eradication therapies has declined,in part due to the development of H.pylori resistant strains.Alternative anti-H.pylori treatments are currently becoming more popular than the traditional eradication methods.Components that may be used either as a monotherapy or,in combination with antimicrobials,resulting in a more effective anti-H.pylori therapy have been investigated in depth by several researchers.One of the potential therapies is probiotic cultures;promising results have been observed in initial studies with numerous probiotic strains.Nevertheless,many questions remain unanswered.In this article,we comprehensively review the possible mechanisms of action of probiotics on H.pylori infection,and present the results of published studies using probiotics as possible agents to control H.pylori infection in children.The effect of the addition of probiotics to the standard H.pylori eradication therapy for the prevention of antibiotic associated side-effects is also discussed. | Lucia Pacifico John Frederick Osborn Enea Bonci Sara Romaggioli Rossella Baldini Claudio Chiesa | 2014 | World Journal of Gastroenterology2014，20，3： | 8 |
| 20 | K48-1inked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites显示文摘 | Frederick A Mallette | 2012 | Cell Research2012，22，8： | 7 |
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