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| 1 | Berberine behind the thriller of marked symptomatic bradycardia显示文摘Berberine is used in traditional Chinese medicine for the treatment of congestive heart failure, hypertension, diabetes, and dyslipidaemia and has a good safety profile. We report a case of a 53-year-old sportsman referred to our hospital for the onset of fatigue and dyspnoea upon exertion after he started berberine to treat hypercholesterolaemia. An electrocardiogram showed sinus bradycardia (45 bpm), first-degree atrioventricular block, and competitive junctional rhythm. An ergometric stress test showed slightly reduced chronotropic competence and the presence of runs of competitive junctional rhythm, atrial tachycardia, and sinus pauses in the recovery. After 10 d of wash-out from berberine, the patient experienced a complete resolution of symptoms, and an ergometric stress test showed good chronotropic competence. An electrocardiogram Holtershowed a latent hypervagotonic state. This is the first case report that shows that berberine could present certain side effects in hypervagotonic people, even in the absence of a situation that could cause drug accumulation. Therefore, berberine's use should be carefully weighed in hypervagotonic people due to the drug's bradycardic and antiarrhythmic properties, which could became proarrhythmic, exposing patients to potential health risks. | Margherita Cannillo Simone Frea Cristina Fornengo Elisabetta Toso Giancarlo Mercurio Stefania Battista Fiorenzo Gaita | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 2 | Does kidney transplantation onto the external iliac artery affect the haemodynamic parameters of the cavernosal arteries?显示文摘减少的 cavernosal 在肾通过端对端的吻合在接受者移植 revascularized 到内部肠骨的动脉以后,动脉的流入被假设了是可勃起的机能障碍的可能的原因,在外部肠骨的动脉建议那 end-to-side 吻合更好。学习是有希望地由评估在可勃起的功能,荷尔蒙侧面和阴茎血流动上评估外部肠骨的动脉的使用的效果的这的目的在 end-to-side 前后在 22 个接受者的一个连续系列在阴茎颜色 Doppler 超声参数变化外部肠骨的动脉移植。可勃起的功能可勃起的函数(IIEF-EF ) 领域 20 的吝啬的国际索引显著地减少了 3 个月在以后移植(18.09 ± 6.33 对 22.50 ± 7.09, P=0.01 ) 。在山峰的减小收缩速度(PSV ) 为到方面的多孔的动脉 homolateral 是重要的移植(42.60 ± 18.77 对 52.01 ± 19.91, P=0.01 ) 。吝啬的手术后的目的心脏舒张的速度(EDV ) 没与外科手术前的价值(P=0.74 ) 显著地不同。没有统计差别在睾丸激素或催乳激素的浆液层次被发现。在外部肠骨的动脉吻合的肾接枝生产了重要(P=0.01 ) 在在在正常阀值上面留下了的 homolateral cavernosal 动脉的动脉的流入的减小。这些 haemodynamic 是否变化,能解释要证明的手术后的可勃起的功能遗体变得更坏。 | Paolo Gontero Marco Oderda Claudia Filippini Francesco Fontana Elisa Lazzarich Piero Stratta Ernesto Turello Alessandro Tizzani Bruno Frea | 2012 | Asian Journal of Andrology2012，14，4： | 2 |
| 3 | Some relationships between environmental reliability and seed dormancy in desert annual plants显示文摘 | Freas K E Kemp P R | 1983 | Journal of Ecology1983，71，： | 1 |
| 4 | Tension-free vaginaltape versus transobturator tape as surgery for stress urinary incontinence: results of a multicentre randomised Irial显示文摘 | Porena M Costantini E Frea B | 2007 | Eur Urol2007，52，5： | 1 |
| 5 | The wild west of executive coaching显示文摘 | Sherman S Freas A | 2004 | Med Surg Nurs2004，13，1： | 1 |
| 6 | Evaluation of MEMS materials of construction for implantable medical devices 显示文摘 | KOTZAR G FREAS M ABEL P | 2002 | Biomaterials2002，23，： | 1 |
| 7 | Effect of fluoride-resistant micro-organism on dental caries显示文摘 | Rosen S Frea JI Hsu SM | | 0，，02： | 1 |
| 8 | Survival and im- pact of clinical prognostic factors in surgically treated metastatic renal ceil carcinoma显示文摘 | TOSCO L VANPOPPEL H FREA B | 2013 | Eur Urol2013，63，4： | 1 |
| 9 | Morbidity and quality of life in elderly patients receiving ileal conduit or orthotopic neobladder after radical cystectomy for invasive bladder cancer显示文摘 | Sogni F Brausi M Frea B | 2008 | Urology2008，71，5： | 1 |
| 10 | Testing protein-walled microcapsules for the rearing of first-feeding gilthead seabream Sparus aurata L显示文摘 | Yúfrea M Sarasquete C Fernandez-Diaz C | | 0，，02： | 1 |
| 11 | Proteolytic 180 labeling for comparative proteomics: Model studies with two serotypes of adenovirus 显示文摘 | Yao X Freas A Ramirez J | 2001 | Anal Chem2001，73，： | 1 |
| 12 | Proteolytic 180 labeling for comparative proteomics: model studies with two serotypes of adenovirus显示文摘 | Yao X Freas A Ramirez J | 2001 | Anal Chem2001，73，： | 1 |
| 13 | Prognostic role of myocardial performance index on long-term survival after heart transplantation : a prospective study显示文摘 | Frea S Capriolo M Bergamasco L | 2013 | Echocardiography2013，30，9： | 1 |
| 14 | Tension-free vaginal tape versus transobturator tape as surgery for stress urinary incontinence:results of a multicentre randomised trial显示文摘 | Porena M Costantini E Frea B | | 0，，05： | 1 |
| 15 | Some relationships between environmental reliability and seed dormancy in desert annual planls显示文摘 | Freas K E Kemp P R | 1983 | Journal of Ecology1983，71，： | 1 |
| 16 | Outflow tract premature ventricular depolarizations after atrial fibrillation ablation may reflect autonomic influences显示文摘 | Patel PJ Ahlemeyer L Freas M | 2014 | J Interv Cardiol Electrophysiol2014，41，2： | 1 |
| 17 | Some relationships between environmental reliability and seed dormancy in desert annual plants 显示文摘 | Freas K E Kemp P R | 1983 | Journal of Ecology1983，71，： | 1 |
| 18 | Metastasis markers in bladder cancer: a review of the literature and clinical considerations显示文摘 | Gontero P Banisadr S Frea B | 2004 | Eur Urol2004，46，3： | 1 |
| 19 | Some relationships between environmental reliability and seed dormancy in desert annual plants显示文摘 | Freas K E Kemp P R | 1983 | Journal of Ecology1983，71，： | 1 |
| 20 | The effect of carbon black particle size on multifunction additive-carbon black interaction显示文摘 | H Isma P K Frea E Shen | 1995 | Eur Polym J1995，31，11： | 1 |
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