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| 1 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 2 | Genetic and phylogenetic analysis of env subtype G and centre Africa显示文摘 | Tanssens W Hevndrick K Fransen K | 1994 | AIDS Res Hum Retroviruses1994，10，： | 1 |
| 3 | Mutation analysis of the BRAF, ARAF and RAF-1 genes inhuman colorectal adenocarcinomas 显示文摘 | Fransen K Klintenas M Osterstrom A | 2004 | Carcinogenesis2004，25，4： | 1 |
| 4 | Mutation analysis of the 13RAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas 显示文摘 | Fransen K Klintenas M Osterstrom A Dimberg J Monstein H J Sederkvist P | 2004 | Carcinogenesis2004，25，： | 1 |
| 5 | An in vitro model for the study of microglia-induced neurodegeneration:involvement of nitric oxide and tumor necrosis factor-alpha显示文摘 | Hemmer K Fransen L Vanderstichele H | 2001 | Neurochem Int2001，38，： | 1 |
| 6 | The oxidation of toluene on various molybdenum-contatining catalysts显示文摘 | Nag N K Fransen T Mars P | 1981 | J Catal1981，68，： | 1 |
| 7 | Matrix metalloproteinase (MMP) -1, -2, -3 and -9 promoter polymorphisms in coloreetal cancer 显示文摘 | Elander N Soderkvist P Fransen K | 2006 | Anticancer Res2006，26，1： | 1 |
| 8 | Evaluation of four HIV antigen tests显示文摘 | Fransen K Beelaert G Van der GG | 2001 | J Virol Methods2001，93，： | 1 |
| 9 | Comparative evaluation of eight commercial enzyme linked immunosorbent assays and 14simple assays for detection of antibodies to HIV显示文摘 | Beelaert G Vercauteren G Fransen K | 2002 | J Virol Methods2002，105，2： | 1 |
| 10 | Prevalence of tinnitus and audiomet-ric shape显示文摘 | Demeester K van Wieringen A Hendrickx JJ Topsakal V Fransen E Van Laer L | | 0，，7： | 1 |
| 11 | Genetic and phylogenetic analysis of env subtypes G and H in central Africa 显示文摘 | Janssens W Heyndrickx L Fransen K | 1994 | AIDS Res Hum Retroviruses1994，10，7： | 1 |
| 12 | Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn' s disease 显示文摘 | Fransen K Visschedijk M C van Sommeren S | 2010 | Hum Mol Genet2010，19，17： | 1 |
| 13 | Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role 0{ nitric oxide synthase显示文摘 | Lemmens K Fransen P Sys SU | 2004 | Circulation2004，109，3： | 1 |
| 14 | Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas 显示文摘 | Fransen K Klintenas M Osterstrom A | 2004 | Careinogenesis2004，25，4： | 1 |
| 15 | A modified agar medium for the screening of proteolytic activity of starter cultures for meat fermentation purposes intern显示文摘 | Fransen N G O' Conner M B Arendt E K | 1997 | Food Microb1997，36，： | 1 |
| 16 | Mutation analysis of the BRAF,ARAF and RAF-1 genes in human colorectal adenocar-cinomaa显示文摘 | Fransen K Klintenas M Osterstrom A | 2004 | Carcinogenesis2004，25，52： | 1 |
| 17 | A comparison of enzyme-aided bleaching of softwood paper pulp using combinations of xylanase,mannanase and α-galactosidase显示文摘 | Clarke J H Davidson K Rixon J E Halstead J R Fransen M P Gilbert H J Hazlewood G P | | 0，，06： | 1 |
| 18 | Library use and under- graduate student outcomes~ New evidence for students' re- tention and academic success显示文摘 | Soria K M Fransen J Nackerud S | 2013 | Portal: Libraries and the Academy2013，，14： | 1 |
| 19 | Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatons polyposis coli mutations in primary colorectal adenocarcinoma显示文摘 | Fransen K Dimberg J Osterstrom A | 2002 | Surgery2002，131，： | 1 |
| 20 | Mitochondrial and peroxisomal targeting of alpha-methylacyl-CoA raeemase in humans显示文摘 | Amery L Fransen M De Nys K | 2000 | J Lipid Res2000，41，： | 1 |
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