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| 1 | 流行性乙型脑炎强毒株和弱毒疫苗株SA14-14-2对猴子和小鼠的致病性和病理学研究显示文摘为了解乙型脑炎 (乙脑 )减毒活疫苗弱毒株SA14 14 2神经毒力的减弱程度 ,本文对弱毒株及其原株SA14强毒株进行了猴体和小白鼠的致病性和病理学变化的比较试验。SA14强毒株病毒 (原始滴度 6 15× 10 8/ml) ,以10 -2 和 10 -4 ~ 10 -7不同稀释度于丘脑两侧合并脊髓注射恒河猴 ,每组除 10 -4 1只外其余均为 2只。另以 10 -4 和10 -6~ 10 -8不同稀释度脑内注射小鼠 ,每组 8只。结果猴子除 10 -4 1只外其余全部发病死亡 ,小鼠则全部死亡。SA14 14 2以 1∶5稀释病毒 (原始滴度为 8× 10 6/ml)按同样方法注射 4只猴和 30只小鼠 ,结果全部存活。另以SA1410 -2 病毒皮下注射 3只猴未死亡 ,而以 10 -1皮下注射 30只小鼠时则全部死亡。SA14 14 2以 1∶5稀释病毒皮下注射小鼠时则全部存活。病理组织学结果显示二种动物接种SA14株强毒后主要表现为弥散性脑脊髓炎 ,以神经细胞坏死为其主要特征和最突出的病变。猴子的病变以脊髓前角、丘脑和中脑黑质为重 ,小鼠的病变则以大脑皮质、海马部最重 ,脊髓的病变却比脑轻。接种弱毒株的动物则仅有轻微炎症反应、神经细胞坏死极少出现。以上结果表明以脑内接种时恒河猴和小鼠对乙脑病毒均高度敏感 ,以皮下接种时小鼠的敏感性高于猴子。乙脑SA14 14 | 凌静萍 朱荫耕 杜桂枝 朗书惠 贾丽丽 俞永新 周铁群 Scott B Halstead | 2000 | 微生物学免疫学进展2000，28，4： | 2 |
| 2 | A mathematical model for hydrocarbon auto-ignition at high pressures显示文摘 | Halstead M Kirsch L Prothero A | 1975 | Proc Royal Society of London1975，246，： | 2 |
| 3 | The effects of rectal probe electrostimulation on spinal cord injury spasticity显示文摘 | Halstead LS Seager SW | 1991 | Paraplegia1991，29，1： | 1 |
| 4 | Role of gastroesophageal reflux in pedi- atric upper airway disorder 显示文摘 | Lucinda A Halstead MD | 1999 | Otolaryngology - head and Neck Surgery1999，120，2： | 1 |
| 5 | Underlying mechanisms of pharmacology and toxicity of a novel PPAR agonist revealed using rodent and canine hepatocytes显示文摘 | Guo Y Jolly R A Halstead B W | 2007 | Toxicol Sci2007，96，2： | 1 |
| 6 | Stochastic simplification of aggregate detail显示文摘 | COOK P-L HALSTEAD J PLANCK M | 2007 | ACM Transactions on Graphics2007，26，3： | 1 |
| 7 | Plants in space 显示文摘 | Halstead T W Dutcher F R | 1987 | Annu Rev Plant Physiol1987，38，： | 1 |
| 8 | Liquid chromatographic determination of honokiol and magnolol in Hou Po (Magnolia officinalis ) as the raw herb and dried aqueous extract显示文摘 | Lee S Khoo C Halstead C | 2007 | J AOAC Int2007，90，5： | 1 |
| 9 | Mucosal cysts of the maxillary sinus: report of75 cases显示文摘 | Halstead CL | 1973 | J Am Dent Assoc1973，87，7： | 1 |
| 10 | Composite aortic root replacement in acute type A dissection: time to rethink the indica- tions 显示文摘 | Halstead JC Spielvogel D Meier DM | 2005 | Eur J Cardiothorac Surg2005，27，4： | 1 |
| 11 | Neutralization and antibody-dependent enhancement of dengue viruses显示文摘 | Halstead SB | 2003 | Adv Virus Res2003，60，： | 1 |
| 12 | Activation of vascular smooth muscle parathyroid hormone receptor inhibits wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis 显示文摘 | Cheng SL Shao JS Halstead LR | 2010 | Circ Res2010，107，2： | 1 |
| 13 | Nurse Educator Competencies: Creating an Evidence-based Practice for Nurse Educators显示文摘 | Halstead J H | 2008 | J Cont Educ Nurs2008，39，2： | 1 |
| 14 | Progress in plant research in space 显示文摘 | Dutcher F R Hess E L Halstead T W | 1994 | Adv Space Res1994，14，： | 1 |
| 15 | Stochastic simplification of aggregate detail显示文摘 | Cook P-L Halstead J Planck M | 2007 | ACM Transactions on Graphics2007，26，3： | 1 |
| 16 | ??Examining Walkability and Social Capital as Indicators of Quality of Life at the Municipal and Neighborhood Scales显示文摘 | Rogers Shannon H John M Halstead Kevin H Gardner Cynthia H Carlson | 2010 | Quality of Life2010，6，2： | 1 |
| 17 | Comparing obiective service failures and subjective complaints 显示文摘 | Halstead D Morash E Ozment J | 1996 | Journal of Business Research1996，36，2： | 1 |
| 18 | Dengue: a continu-ing global threat显示文摘 | Guzman MG Halstead SB Artsob H | 2010 | Nat Rev Micro2010，，： | 1 |
| 19 | Autonomy as an element in Chinese educational reform: a case study of Eng- lish lessons in a senior high school in Beijing显示文摘 | HALSTEAD J MARK ZHU CHUANYAN | 2009 | Asia Pa- cific Journal of Education2009，29，4： | 1 |
| 20 | The effects of rectal probe electrostimulation of spinal cord injury spasticity显示文摘 | Halstead LS Seager SW | 1991 | Paraplegia1991，29，： | 1 |
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