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| 1 | Liver diseases in developing countries显示文摘Liver diseases are an important and largely neglected health issue in low and middle income countries,which carry the highest burden.In this Topic Highlight,experts review hepatitis B and E,alcoholic liver disease,hepatic diseases in human immunodeficiency virus-infected individuals,hepatocellular carcinoma.Numerous gaps in our knowledge that need to be filled are outlined and feasible solutions to the several problems related to diagnosis and management of liver diseases in developing countries are suggested. | Francesca Cainelli | 2012 | World Journal of Hepatology2012，4，3： | 4 |
| 2 | Management of chronic hepatitis B in children: An unresolved issue显示文摘 | Claudia Della Corte Valerio Nobili Donatella Comparcola Francesca Cainelli Sandro Vento | 2014 | J Gastroenterol Hepatol2014，，5： | 2 |
| 3 | Reactivation of replication of hepatitis B and C viruses after immunosuppressive therapy: an unresolved issue显示文摘 | Sandro Vento Francesca Cainelli Maria Serena Longhi | 2002 | Lancet Oncology2002，，6： | 1 |
| 4 | 丙肝病毒和人的免疫不全病毒传播发送: 差别和类似显示文摘 Bouare et al found that hepatitis C virus (HCV) infection in Malian women is mainly transmitted through medical procedures with contaminated supplies, and that human immunodeficiency virus (HIV) transmission is predominantly sexual. The results of this study confirm those of a recent case-control study in New York and Oregon which demonstrated that healthcare exposures represent an important source of new HCV infections in United States. HCV seroprevalence was only 0.2% in pregnant, young Malian women, indicating that hygiene improved in healthcare facilities over time. Heterosexual transmission of HCV is exceptional, and can occur, from males to females, in extremely rare occasions in case of vaginal mucosal damage or less rarely through anal intercourse. The Malian study did not show an association between HIV infection and hospitalization, transfusion, tattoo, dental care. Transmission by needle-stick injury occurs in 0.9%-2.2% of exposures from HCV-infected subjects and in 0.1%-0.3% of exposures from HIV-infected in- dividuals. HCV is therefore more transmissible through percutaneous exposure. | Francesca Cainelli | 2013 | World Journal of Hepatology2013，5，5： | 1 |
| 5 | Infections in patients with cancer undergoing chemotherapy: aetiology, prevention, and treatment显示文摘 | Sandro Vento Francesca Cainelli | 2003 | Lancet Oncology2003，，10： | 1 |
| 6 | Reactivation of replication of hepatitis B and C viruses after immunosuppressive therapy: an unresolved issue显示文摘 | Sandro Vento Francesca Cainelli Maria Serena Longhi | 2002 | Lancet Oncology2002，，6： | 1 |
| 7 | Lung infections after cancer chemotherapy显示文摘 | Sandro Vento Francesca Cainelli Zelalem Temesgen | 2008 | Lancet Oncology2008，，10： | 1 |
| 8 | Infections and solid organ transplant rejection: a cause-and-effect relationship?显示文摘 | Francesca Cainelli Sandro Vento | 2002 | Lancet Infect Dis2002，2，7： | 1 |
| 9 | 病毒是自身免疫性肝炎的触发因素吗?(上)显示文摘自身免疫性肝炎(AH)是一种少见的疾病,病因学不明,以女性为主,人群发病率为0.01-0.02%,特征性的血清学变化为血清IgG显著升高。自然史以反复发生在肝小叶内和汇管区交界面的坏死性炎症(碎片状坏死)最终导致肝硬化甚至肝衰竭,在所有自身免疫性疾病中它对皮质激素治疗的反应最好。 | Sandro Vento Francesca Cainelli 姚勤伟(编译) 杨月(审校) | 2006 | 传染病网络动态2006，，6： | 0 |
| 10 | 病毒是自身免疫性肝炎的触发因素吗?(下)显示文摘4.病毒在AH2型中是否也起了这种作用? 这种自身免疫性肝病标志性的靶点,即LKM1,是细胞色素P450IID6(CYP2D6),肝脏P450酶家族的一个成员。Manns等人认为针对由LKM1抗体识别的CYP2D6主要抗原决定簇的反应可能通过对丙型肝炎病毒(HCV)或单纯疱疹病毒1型(HSVI)的交叉反应而产生,因为HCV E1包膜区域的310-324位氨基酸和HSV1的快速调节蛋白IE175的156-170位氮基酸与CYP2D6免疫决定区的254.271位氨基酸具有序列同源性,可被85%的AH2型患者所识别。然而Klein等人证明针对细胞色素P2D6(CYP2D6196-218)的线性B细胞抗原决定簇的反应发生于多到68%的AH2型患者,而在LKM1+ve的HCV感染患者身上的发生率只有18%。 | Sandro Vento Francesca Cainelli 姚勤伟(编译) 杨月(审校) | 2006 | 传染病网络动态2006，，7： | 0 |
| 11 | Defensive medicine:It is time to finally slow down an epidemic显示文摘Defensive medicine is widespread and practiced the world over, with serious consequences for patients, doctors, and healthcare costs. Even students and resi-dents are exposed to defensive medicine practices and taught to take malpractice liability into consideration when making clinical decisions. Defensive medicine is generally thought to stem from physicians' perception that they can easily be sued by patients or their relatives who seek compensation for presumed medical errors. However, in our view the growth of defensive medicine should be seen in the context of larger changes in the conception of medicine that have taken place in the last few decades, undermining the patient–physician trust, which has traditionally been the main source of professional satisfaction for physicians. These changes include the following: time directly spent with patients has been overtaken by time devoted to electronic health records and desk work; family doctors have played a progressively less central role; clinical reasoning is being replaced by guidelines and algorithms; the public at large and a number of young physicians tend to believe that medicine is a perfect science rather than an imperfect art, as it continues to be; and modern societies do not tolerate the inevitable morbidity and mortality. To finally reduce the increasing defensive behavior of doctors around the world, the decriminalization of medical errors and the assurance that they can be dealt with in civil courts or by medical organizations in all countries could help but it would not suffice. Physicians and surgeons should be allowed to spend the time they need with their patients and should give clinical reasoning the importance it deserves. The institutions should support the doctors who have experienced adverse patient events, and the media should stop reporting with excessive evidence presumed medical errors and subject physicians to 'public trials' before they are eventually judged in court. | Sandro Vento Francesca Cainelli Alfredo Vallone | 2018 | World Journal of Clinical Cases2018，6，11： | 0 |
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