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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Hodgkin/ReedSternberg cells and Hodgkin's disease in patients with Bcell chronic lymphocytic leukaemia:an immunohistological,molecular and clinical study of four cases suggesting a heterogeneous pathogenetic background显示文摘 | Pescarmona E Pignoloni P Mauro FR | 2000 | Virchows Arch2000，437，： | 1 |
| 3 | Enzymatic activity in the activated-sludge floc matrix显示文摘 | Frφlund B Griebe T Nielsen P H | | 0，，4： | 1 |
| 4 | Acute myeloid leukemia(AML)with 9q aberrations occurring within a non-complex karyotype is highly associated with CEBPA and NPM1 mutations–a joint analysis of the German-Austrian AML Study Group(AMLSG)and Cancer and Leukemia Group B(CALGB)显示文摘 | Corbacioglu A Frhling S Paschka P | 2007 | Blood2007，110，1： | 1 |
| 5 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium)显示文摘 | J Nouwen C Cornelis R De Fré M Wevers P Viaene C Mensink J Patyn L Verschaeve R Hooghe A Maes M Collier G Schoeters R Van Cleuvenbergen P Geuzens | 2001 | Chemosphere2001，，4： | 1 |
| 6 | Enzymatic activity in the activated-sludge floc matrix显示文摘 | Frlund B Griebe T Nielsen P H | 1995 | Appl Microbiol Biotechnol1995，43，： | 1 |
| 7 | Gender related association between β2 fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in greenland inuit显示文摘 | de Mast MPM de Knijff P Green FR | 1995 | Arterioscler Thromb Vase Biol1995，15，： | 1 |
| 8 | Geometric factors affecting dentin bonding in root canals: a theoretical modeling approach显示文摘 | Tay FR Loushine RJ Lambrechts P | 2005 | J Endod2005，31，8： | 1 |
| 9 | Use of a nonimmunogenic acellular dermal allograft for soft tissue augmentation: a preliminary report显示文摘 | Schwartz BM Silverstein P | 1996 | Aesthetic Surg1996，16，： | 1 |
| 10 | Magnetic resonance imaging and the management of parapharyngeal space tumors 显示文摘 | Wanamaker JR Lavertu P | 1996 | Head Neck1996，18，： | 1 |
| 11 | Age-related differences on event-related potentials and brain rhythm oscillations during working memory activation显示文摘 | Missonnier P Herrmann FR Rodriguez C | 2011 | J Neural Transm2011，118，6： | 1 |
| 12 | Association of the APC gene product with beta-catenin显示文摘 | Rubinfeld B Souza B Albert I Muller O Chamberlain SH Masiarz FR Munemitsu S Polakis P | | 0，，： | 1 |
| 13 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 14 | Expression of odorant-binding proteins and chemosensory proteins in some Hymenoptera显示文摘 | Calvello M Brandazza A Navarrini A Dani FR Turillazzi S Felicioli A Pelosi P | | 0，，04： | 1 |
| 15 | Molecular predictors of outcome with gefitinib in a phase Ⅲ placebo-controlled study in advanced non-small-cell lung cancer显示文摘 | Hirsch FR Varella-Garcia M Jr Bunn P A | | 0，，31： | 1 |
| 16 | Ptasmacytomas of the head and neck 显示文摘 | Miller FR Lavertu P Wanamaker dR | 1998 | Otolaryngol Head Neck Surg1998，119，6： | 1 |
| 17 | Intraepithelial gamma/delta T cells in duodenal mucosa are related to the immune state and survival time in AIDS显示文摘 | Nilssen D Muller F Oktedalen O Frland SS Fausa O Halstensen TS Brandtzaeg P | 1996 | J Virol1996，70，6： | 1 |
| 18 | Enzymatic activity in the 显示文摘 | Frφlund B Griebe T Nielsen activated sludge floe matrix P H | 1995 | Applied Microbiological Biotechnology1995，43，： | 1 |
| 19 | Major lower limb amputations in the elderly observed over ten years: the role of dia- betes and peripheral arterial disease 显示文摘 | Carmona GA Hoffmeyer P Herrmann FR | 2005 | Diabetes Metab2005，31，5： | 1 |
| 20 | Interactionbetween HERC1 and M2-type pyruvate kinase显示文摘 | Garcia-Gonzalo FR Cruz C Munoz P | 2003 | FEBSLett2003，539，： | 1 |
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