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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Mice with a null mutation of the TGF-alpha gene have abnormal skin architecture,wavy hair,and curly whiskers and often develop corneal inflammation显示文摘 | MANN G B FOWLER K J GABRIEL A | 1993 | Cell1993，73，2： | 1 |
| 3 | Flexural strength of reinforced polymer concrete made with recycled plastic waste显示文摘 | Rebeiz K S Fowler D W | 1996 | ACI structural journal1996，93，5： | 1 |
| 4 | US for detecting renal calculi with nonenhanced CT as a reference standard 显示文摘 | Fowler K A B Locken J A Duchesne J H | 2002 | Radiology2002，222，1： | 1 |
| 5 | Leaching of zinc sulfide by Thiobacillus ferrooxidans: Bacterial oxidation of the sulfur product layer increases the rate of zinc sulfide dissolution at high concentrations of ferrous ions显示文摘 | FOWLER T A CRUNDWELL F K | 1999 | Applied and Environme- ntal Microbiology1999，65，12： | 1 |
| 6 | Choledocholithiasis:endoscopic vers 118 laparopie management显示文摘 | Heili M J Wintz N K Fowler D L | | 0，，02： | 1 |
| 7 | Molecular and morphological analyses of thecuttlefish Sepia apama indicate a complex population structure显示文摘 | Kassahn K S Donnellan S C Fowler A J | 2003 | Marine Biology2003，143，5： | 1 |
| 8 | The influence of thermochemical sulphate reduction on hydrocarbon tomposition in Nisku reservoirs,Brazeau river area,Alberta,Canada显示文摘 | MANZANO B K FOWLER M G MACHEL H G | 1997 | Organic Geochemistry1997，27，78： | 1 |
| 9 | Application of petroleum geochemistry to exploration and reservoir management显示文摘 | Peters K E Fowler M G | 2002 | Organic Geochemistry2002，33，： | 1 |
| 10 | Predicted and measured petrophysical and geochemical characteristics of the Egret Member oil source rock, Jeanne d'Arc Basin, offshore eastern Canada 显示文摘 | Huang Z Williamson M A Fowler M G Mcalpine K D | 1994 | Mar PetGeol1994，11，3： | 1 |
| 11 | The roles of cellular reactive oxygen species,oxidative stress and antioxidants in pregnancy outcomes显示文摘 | A1-Gubory K H Fowler P A Garrel C | 2010 | The International Journal of Biochemistry & Cell Biology2010，42，10： | 1 |
| 12 | Adolescent chnical outcomes for young people with attention-deficit hyperactivity disorder 显示文摘 | Langley K Fowler T Ford T | 2010 | Br J Psychiatry2010，196，3： | 1 |
| 13 | Prevalence of peripheral arterial disease:persistence of excess risk in former smokers显示文摘 | Fowler B Jamrozik K Norman P | | 0，，03： | 1 |
| 14 | Re-examining pluton emplacement processes显示文摘 | Paterson S R Fowler T K | | 0，，： | 1 |
| 15 | Cognitive control of drug craving inhibits brain reward regions in cocaine abusers显示文摘 | Volkow ND Fowler JS Wang GJ Telang F Logan J Jayne M Ma Y Pradhan K Wong C Swanson JM | | 0，，03： | 1 |
| 16 | Hyperhomoeysteinemia:an independent risk factor for vascular disease显示文摘 | Daly L Robinson K Nanshten E Cahalane S Fowler B | 1991 | N Engl J Med1991，324，： | 1 |
| 17 | The influence of thermochemical sulphate reduction on hydrocarbon composition in Nisku reservoirs, Brazeau river area, Alberta, Canada 显示文摘 | Manzano B K Fowler M G Machel H G | 1997 | Org Geochem1997，27，78： | 1 |
| 18 | A hybridized genetic algorithm to solve parallel machine scheduling problems with sequence dependent setups显示文摘 | FOWLER J W HORNG S M COCHRAN J K | 2003 | International Journal of Industrial Engineering:Theory Applications and Practice2003，10，3： | 1 |
| 19 | Interpreting magmatic fabric patterns in plutons显示文摘 | Paterson S R Fowler T K Schmidt K L | | 0，，： | 1 |
| 20 | Prevention of mother- to-child HIV transmission in resource-poor countries: Translating research into policy and practice显示文摘 | de Cock K M Fowler M Mercier E | 2000 | JAMA2000，283，： | 1 |
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