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| 1 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 2 | Current surgical treatment strategies for hepatocellular carcinoma in North America显示文摘Hepatocellular carcinoma(HCC) is an aggressive tumor that often occurs in the setting of chronic liver disease.Many patients do not initially manifest any symptoms of HCC and present late when cure with surgical resection or transplantation is no longer possible.For this reason,patients at high risk for developing HCC are subjected to frequent screening processes.The surgical management of HCC is complex and requires an inter-disciplinary approach.Hepatic resection is the treatment of choice for HCC in patients without cirrhosis and is indicated in some patients with early cirrhosis(Child-Pugh A).Liver transplantation has emerged in the past decade as the standard of care for patients with cirrhosis and HCC meeting Milan criteria and in select patients with HCC beyond Milan criteria.Loco-regional therapy with transarterial chemoembolization,transarterial embolization,radiofrequency ablation and other similar local treatments can be used as neo-adjuvant therapy to downstage HCC to within Milan criteria or as a bridge to transplantation in patients on transplant wait list. | Adeel S Khan Kathryn J Fowler William C Chapman | 2014 | World Journal of Gastroenterology2014，20，41： | 3 |
| 3 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 4 | 综合老化腐蚀试验显示文摘介绍了综合老化腐蚀试验,包括其循环试验条件、腐蚀试验结果验证及试验方法的改进,指出该方法是检验工业防护涂层实用性的最有效试验方法之一。 | J Quill J Gauntner S Fowler J Regan 张恒 孙杏蕾 | 2015 | 上海涂料2015，53，5： | 3 |
| 5 | Leukocyte and Bacterial Counts Do Not Correlate With Severity of Symptoms in Men With Chronic Prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Anthony J. Schaeffer Jill S. Knauss J. Richard Landis Kathleen J. Propert Richard B. Alexander Mark S. Litwin J. Curtis Nickel Michael P. O’leary Robert B. Nadler Michel A. Pontari Daniel A. Shoskes Scott I. Zeitlin Jackson E. Fowler Carissa A. Mazurick J | 2002 | The Journal of Urology2002，，3： | 2 |
| 6 | Variant design for mechanical artifacts: A state-of-the-art survey显示文摘 | FOWLER J E | 1996 | Engineering with Computers1996，12，1： | 1 |
| 7 | Mice with a null mutation of the TGF-alpha gene have abnormal skin architecture,wavy hair,and curly whiskers and often develop corneal inflammation显示文摘 | MANN G B FOWLER K J GABRIEL A | 1993 | Cell1993，73，2： | 1 |
| 8 | Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models显示文摘 | Sheu MY Fowler AJ Kao J | 2002 | J Invest Dermatol2002，118，1： | 1 |
| 9 | Effect of obstacle size and spacing on the initial stage of flame acceleration in a rough tube显示文摘 | Ciccarelli G Fowler C J Bardon M | 2005 | Shock Waves2005，14，3： | 1 |
| 10 | Estimation of nisin in food显示文摘 | Tramer J Fowler JJ | 1964 | J Sci Food Agric1964，15，： | 1 |
| 11 | A hybrid approach using the analytic hierarchy process and integer programming to screen weapon systems projects 显示文摘 | Greiner M A Fowler J W Shunk D L | 2003 | IEEE Transactions on Engineering Management2003，50，2： | 1 |
| 12 | Relationship of pretreatment transurethral resection of the prostate to survival without distant metastases in patients treated with ^125I-implantation for localized prostatic cancer显示文摘 | Fowler J E Jr Fisher H A Kaiser D L | 1984 | Cancer1984，53，9： | 1 |
| 13 | Transport of endocannabinoids across the plasma mem- brane and within the cell 显示文摘 | Fowler C J | 2013 | FEBS J2013，280，9： | 1 |
| 14 | Prevalence of chronic disabling fatigue in children and adolescents 显示文摘 | Farmer A Fowler T Scourfield J | 2004 | BrJ Psychiatry2004，，184： | 1 |
| 15 | Intravesieal treatment of overactive bladder显示文摘 | Fowler C J | 2000 | Urolo- gy2000，55，5： | 1 |
| 16 | The neural control of mie- turition显示文摘 | Clare J Fowler Derek Griffiths | 2008 | Nature Reviews Neuroscienee2008，9，： | 1 |
| 17 | Mycobacteria activate gam- madelta T-ceU anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immu- notherapy 显示文摘 | Fowler DW Copier J Wilson N | 2012 | Cancer Immunol Immunother2012，61，4： | 1 |
| 18 | Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies显示文摘 | Stein L Kircik L Fowler J | 2014 | J Drugs Dermatol2014，13，3： | 1 |
| 19 | US for detecting renal calculi with nonenhanced CT as a reference standard 显示文摘 | Fowler K A B Locken J A Duchesne J H | 2002 | Radiology2002，222，1： | 1 |
| 20 | Enrich-ment of microsatellite from the citrus genome using bi-otinylated oligonucleotide sequence bound to strepta-vidin-coated magnetic particles显示文摘 | KIJAS J M FOWLER J C GARBETT C A | 1994 | Biotechniques1994，16，4： | 1 |
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