|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Relationship of pretreatment transurethral resection of the prostate to survival without distant metastases in patients treated with ^125I-implantation for localized prostatic cancer显示文摘 | Fowler J E Jr Fisher H A Kaiser D L | 1984 | Cancer1984，53，9： | 1 |
| 3 | Nanoscale Materials with Mesostructured Interiors显示文摘 | Fowler C E Khushalani D Lebean B | 2001 | Adv Mater2001，13，9： | 1 |
| 4 | Developmental regula tion of low-temperature tolerance in winter wheat显示文摘 | Mahfoozi S Limin A E Fowler D B | 2001 | Annals of Botany2001，87，： | 1 |
| 5 | Nanoscale materials with mesostructured interiors显示文摘 | Fowler C E Khushalani D Lebeau B | 2001 | Adv Mater (Weinheim Ger)2001，13，： | 1 |
| 6 | Interactions among factors regulating phenological development and acclimation rate determine lowtemperature tolerance in wheat显示文摘 | Fowler D B Limin A E | 2004 | Annals of Botany2004，94，5： | 1 |
| 7 | Multidetector computed tomography for acute pulmonary embolism显示文摘 | Stein P D Fowler S E Goodman L R | | 0，，22： | 1 |
| 8 | Predictors of first repeat biopsy cancer detection with suspected local stage prostate cancer显示文摘 | Fowler J E Jr Bigler S A Miles D | 2000 | J Urol2000，163，3： | 1 |
| 9 | Neurologic findings in infants with deformational plagiocephaly显示文摘 | Fowler E Becker D Pilgram T | 2008 | J Child Neurol2008，23，7： | 1 |
| 10 | Muhidetector computed tomography for acute pulmonary embolism 显示文摘 | Stein P D Fowler S E Goodman L R | 2006 | N Engl J Med2006，354，22： | 1 |
| 11 | Relationship between guard cell length and cold hardiness in wheat显示文摘 | Limin A E Fowler D B | 1994 | Can J Plant Sci1994，74，： | 1 |
| 12 | Photoperiod and temperature interactions regulate low - temperature - induced gene expression in barley 显示文摘 | Fowler D B Breton G Limin A E | 2001 | Plant Physiology2001，127，4： | 1 |
| 13 | Relationship between low- temperature tolerance and vernalization response in wheat and rye 显示文摘 | Fowler D Limin A E Wang S | 1996 | Canadian Journal of Plant Science1996，76，1： | 1 |
| 14 | Interfacial synthesis of hollow microspheres of mesostructured silica显示文摘 | Fowler C E Khushalani D Mann S | | 0，，： | 1 |
| 15 | Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study显示文摘 | Jadwiga A Wedzicha Marc Decramer Joachim H Ficker Dennis E Niewoehner Thomas Sandstr?m Angel Fowler Taylor Peter D’Andrea Christie Arrasate Hungta Chen Donald Banerji | 2013 | The Lancet Respiratory Medicine2013，，3： | 1 |
| 16 | Breeding for winter hardiness in cereals显示文摘 | Fowler D B Limin A E | 1997 | Aeta Agronomiea Hungariea1997，45，3： | 1 |
| 17 | A Census of Nanotube Caps 显示文摘 | Brinkmann G Fowler P W Manolopoulos D E | 1999 | Chem Phys Lett1999，315，： | 1 |
| 18 | Synergistic toughening in rubber modified blends显示文摘 | Fowler M E Keskkula H Paul D R | 1987 | Polymer1987，28，10： | 1 |
| 19 | Interracial synthesis of hollow mierospheres of mesostruetured silica 显示文摘 | FOWLER C E KHUSHALANI D MANN S | 2001 | Chem Commun2001，19，： | 1 |
| 20 | Mechanical behavior of dual-rubber-modified SAN显示文摘 | Fowler M E Keskkula H Paul D R | 1988 | Journal of Applied Polymer Science1988，35，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员