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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Effects of protein content and composition on white noodle making quality: color 显示文摘 | Wang C Kovacs M I P Fowler D B | 2004 | Cereal Chemistry2004，81，： | 1 |
| 3 | Nanoscale Materials with Mesostructured Interiors显示文摘 | Fowler C E Khushalani D Lebean B | 2001 | Adv Mater2001，13，9： | 1 |
| 4 | A system for freezing biological materials显示文摘 | Gusta L V Boyachek M Fowler D B | 1978 | Hort Science1978，13，： | 1 |
| 5 | Developmental regula tion of low-temperature tolerance in winter wheat显示文摘 | Mahfoozi S Limin A E Fowler D B | 2001 | Annals of Botany2001，87，： | 1 |
| 6 | Bar-code technology for medication administration: medication errors and nurse sa- tisfaction显示文摘 | Fowler S B Sohler P Zarillo D F | 2009 | Medsurg Nuts2009，18，2： | 1 |
| 7 | Nanoscale materials with mesostructured interiors显示文摘 | Fowler C E Khushalani D Lebeau B | 2001 | Adv Mater (Weinheim Ger)2001，13，： | 1 |
| 8 | Interactions among factors regulating phenological development and acclimation rate determine lowtemperature tolerance in wheat显示文摘 | Fowler D B Limin A E | 2004 | Annals of Botany2004，94，5： | 1 |
| 9 | Effects of temperature on dehardening and rehardening of winter ceresls显示文摘 | Gusta L V Fowler D B | 1976 | Canada Journal Plant Science1976，56，： | 1 |
| 10 | Effects of temperature on dehardening and rehardening of winter cereals 显示文摘 | GUSTA L V FOWLER D B | 1976 | Canada Journal Plant Science1976，56，： | 1 |
| 11 | Barriers to Swift, Even Flow in the Internal Supply Chain of Perioperative Surgical Services De- partment: A Case Study显示文摘 | FREDENDALL L D CRAIG J B FOWLER P J etal | 2009 | Decision Sciences2009，40，2： | 1 |
| 12 | Relationship between guard cell length and cold hardiness in wheat显示文摘 | Limin A E Fowler D B | 1994 | Can J Plant Sci1994，74，： | 1 |
| 13 | Photoperiod and temperature interactions regulate low - temperature - induced gene expression in barley 显示文摘 | Fowler D B Breton G Limin A E | 2001 | Plant Physiology2001，127，4： | 1 |
| 14 | Petrogenesis of high Ba-Sr plutons from the northern highlands terrane of the British Caledonian Province显示文摘 | FOWLER M B KOCKS H DARBYSHIRE D P F GREENWOOD P B | 2008 | Lithos2008，105，12： | 1 |
| 15 | Bound polaron in a spherical quantum dot: strong electron-phonon coupling case 显示文摘 | Melnikov D V Fowler W B | 2001 | Phys Rev B2001，64，： | 1 |
| 16 | Low temperature processes in a bituminous coal studied by in situ electron spin resonance spectroscopy显示文摘 | Fowler T G Keith B D Rafael Kandiyoti | 1987 | Fuel1987，66，： | 1 |
| 17 | Breeding for winter hardiness in cereals显示文摘 | Fowler D B Limin A E | 1997 | Aeta Agronomiea Hungariea1997，45，3： | 1 |
| 18 | Bound polaron in a spherical quantum dot:strong electron-phonon coupling case显示文摘 | W B Fowler | 1998 | Eur Phys J1998，5，： | 1 |
| 19 | 显示文摘 | CAMPBELL E E B FOWLER P W MITCHELL D | 1996 | Chem Phys Lett1996，250，： | 1 |
| 20 | Effects of protein content and composition on white noodle making quality:Colour显示文摘 | Kovacs M I P Wang C Fowler D B | 2004 | Cereal Chemistry2004，81，： | 1 |
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