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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 3 | Use of oral contraceptive pills and Vulvar vestibulitis:a casecontrol study显示文摘 | Bouchard C Brisson J Fortier M | 2002 | Am J Epidemiol2002，156，3： | 1 |
| 4 | Hormone-sensitive lipaseindependent adipocyte lipolysis duringβ-adrenergic stimulation,fasting,and dietary fat loading显示文摘 | fortier M Wang S P Mauriege P | 2004 | Am J Physiol Endocrinol Metab2004，287，： | 1 |
| 5 | Prostaglandin E2 regulates both interleukin-2 and granulocyte-macrophage colonystimulating factor gene expression in bovine lymphocytes 显示文摘 | Emond V Fortier M A Murphy B D | 1998 | Biol Reprod1998，58，1： | 1 |
| 6 | Novel insights into changes in biochemical properties of keratins 8 and 18 in griseofulvin-induced toxic liver injury显示文摘 | Fortier AM Riopel K Desaulniers M | | 0，，02： | 1 |
| 7 | Effect of a fermented milk combining Lactobacillus acidophilus CL1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea:a randomized,double-blind,placebo-controlled trial显示文摘 | Beausoleil M Fortier N Guénette S | 2007 | Can J Gastroenterol2007，21，11： | 1 |
| 8 | Performance Analysis of a COFDM/FM In-band Digital Audio Broadcasting System 显示文摘 | Scalart P Leclerc M Fortier P | 1997 | IEEE Transactions on Broadcasting1997，43，2： | 1 |
| 9 | Mesenchymal stromal cell derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction 显示文摘 | Rafei M Hsieh J Fortier S | 2008 | Blood2008，112，13： | 1 |
| 10 | Mesenchymal stromal cell-derived cc12 suppresses plasma cell immunoglobulin production via stat3 inactivation and pax5 induction 显示文摘 | Rafei M Hsieh J Fortier S | 2008 | Blood2008，112，13： | 1 |
| 11 | Relationship between climate, pollen concentrations of Ambrosia and medical consultations for allergic rhinhis in Montreal, 1994-2002 显示文摘 | Breton MC Garneau M Fortier I | 2006 | Sci Total Environ2006，370，： | 1 |
| 12 | Effect of a fermented milk combining Lactobacillus acidophilus CL1285 and Lactobacillus casei in the prevention of antibiotic - associated diarrhea : A randomized, double - blind,placebo -controlled trial 显示文摘 | Beausoleil M Fortier N Gu6nette S | 2007 | Can J Gastroenterol2007，21，11： | 1 |
| 13 | Prostaglandin E2 regulates both interleukin-2 and granulocyte-macrophage colony-stimulating factor gene expression in bovine lymphocytes显示文摘 | EMOND V FORTIER M A MURPHY B D | 1998 | BiolReprod1998，58，1： | 1 |
| 14 | Osteoporosis in menopause 显示文摘 | Khan A Fortier M Reid R | 2014 | Obstet Gynaecol Can2014，36，9： | 1 |
| 15 | Automated correction and updating of road databases from high resolution imagery显示文摘 | Auclair Fortier M Ziou D Armenakis C | 2001 | Canadian Journal of Remote Sensing2001，27，1： | 1 |
| 16 | Associations among perceived autonomy support, forms of self-regulation, and persistence: A prospective study 显示文摘 | PELLETIER L G FORTIER M S VALLERAND R J | 2001 | MotivatEmot2001，25，4： | 1 |
| 17 | Association of HLA-G low expressor genotype with severe acute graft-versus-host disease after sibling bone marrow transplantation显示文摘 | Boukouaci W Busson M Fortier C | 2011 | Front Immunol2011，2，： | 1 |
| 18 | Mesenchymal stromal cell- derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction显示文摘 | Rafei M Hsieh J Fortier S | 2008 | Blood2008，12，13： | 1 |
| 19 | Specific proerties of epithelial and stromal cells from the endometrium of cows显示文摘 | FORTIER M A GUIBAULT L A GRASSO F | 1988 | Reprod Fertil1988，83，： | 1 |
| 20 | Large-scale fad- ing and time dispersion parameters of UWB channel in underground mines 显示文摘 | CHEHRI A FORTIER P TARDIF P M | 2008 | International Journal of Antennas and Propagation2008，5，1： | 1 |
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