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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Hormone-sensitive lipaseindependent adipocyte lipolysis duringβ-adrenergic stimulation,fasting,and dietary fat loading显示文摘 | fortier M Wang S P Mauriege P | 2004 | Am J Physiol Endocrinol Metab2004，287，： | 1 |
| 3 | Ammonia,cyclohexane,nitrogen and water adsorption capacities of an activated carbon impregnated with increasing amounts of ZnCI2,and designed to chemisorb gaseous NH3 from an air stream显示文摘 | Fortier H Westreich P Selig S | 2008 | J Colloid Interf Sci2008，320，2： | 1 |
| 4 | Performance Analysis of a COFDM/FM In-band Digital Audio Broadcasting System 显示文摘 | Scalart P Leclerc M Fortier P | 1997 | IEEE Transactions on Broadcasting1997，43，2： | 1 |
| 5 | Large-scale fad- ing and time dispersion parameters of UWB channel in underground mines 显示文摘 | CHEHRI A FORTIER P TARDIF P M | 2008 | International Journal of Antennas and Propagation2008，5，1： | 1 |
| 6 | A large volume pump system for studies of the vertical distribution of fish larvae under open sea conditions显示文摘 | HARRIS R P FORTIER L YOUNG R K | | 0，，04： | 1 |
| 7 | Laboratory diagnosis of cystic hydatic disease显示文摘 | Biava M P Dao A Fortier B | 2001 | World Journal of Surgery2001，25，1： | 1 |
| 8 | Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies 显示文摘 | Fortier I Burton PR Robson P J | 2010 | Int J Epidemiol2010，39，13： | 1 |
| 9 | Reducexi mortality and strokes with off-pump coronary artery bypass grafting surgery in octogenarians显示文摘 | Demaria RG Carder M Fortier S Martineau R Forticr A Cartier R Pellcrin M He bert Y Bouchard D Page P Pcrrault LP | 2002 | Circulation2002，106，121： | 1 |
| 10 | Localization , biosynthesis, processing and isolation of a major 126 kDa antigen of the parasitophorous vacuole of Plasmodium falciparum显示文摘 | Delplace P Fortier B tronchin G | 1987 | Mol Biochem Parasitol1987，23，3： | 1 |
| 11 | POU4Fl is associated with t (8 ;21 ) acute myeloid leukemia and contributes directly to its unique transcriptional signature 显示文摘 | Fortier JM Payton JE Cahan P | 2010 | Leukemia2010，24，5： | 1 |
| 12 | A 50 kilodalton exoantigen specific to the merozoite release-reinvasion stage of Plasmodium falciparum显示文摘 | Delplace P Dubremetz JF Fortier B | 1985 | Mol Biochem Parasitol1985，17，2： | 1 |
| 13 | UWB-based sensor networks for localization in mining environments显示文摘 | CHEHRI A FORTIER P TARDIF P M | 2008 | Ad Hoc Networks2008，7，5： | 1 |
| 14 | Highly-parallel decoding architectures for convolutional turbo codes 显示文摘 | HE Z Y FORTIER P ROY S | 2006 | IEEE Transactions on very Large Scale Intergration Sys- tems2006，14，10： | 1 |
| 15 | Large-scale fading and time dispersion parameters of UWB channel in underground mines显示文摘 | CHEHRI A FORTIER P TARDIF P M | 2008 | International Journal of Antennas and Propagation2008，5，1： | 1 |
| 16 | UWB based sensor net- works for localization in mining environments 显示文摘 | CHEHRI A FORTIER P TARDIF P M | 2009 | Ad Hoc Net- works2009，7，5： | 1 |
| 17 | An investigation of UWB-based wireless networks in industrial automation显示文摘 | CHEHRI A FORTIER P TARDIF P M | 2008 | International Journal of Computer Science and Network Security2008，8，2： | 1 |
| 18 | Cross -layer link adaptation design for UWB -based sensor networks 显示文摘 | CHEHRI A FORTIER P TARDIF P M | 2009 | Computer Communications2009，32，13： | 1 |
| 19 | Cross -layer link adaptation design for UWB -based sensor networks 显示文摘 | CHEI-IRI A FORTIER P TARDIF P M | | Computer Communications0，32，13： | 1 |
| 20 | UWB-based sensor networks for localization in mining environments 显示文摘 | Chehri A Fortier P Tardif P M | 2009 | Ad Hoc Net- works2009，7，5： | 1 |
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