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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation显示文摘Acute humoral rejection (AHR) is uncommon after ABO-compatible liver transplantation. Herein, we report two cases of AHR treated with plasmapheresis and rituximab in two ABO-compatible liver-transplant patients with preformed anti-human leukocyte antigen donor-specif ic antibodies. Patient 1 experienced a biopsy-proven AHR at day 10 post-transplant. She was treated by steroid pulses, and OKT3. Because of persisting signs of biopsy-proven AHR at day 26, she was treated by plasmapheresis and rituximab. Liver enzyme levels did not improve, and she died on day 41. Patient 2 experienced a biopsy-proven AHR on day 10 post-transplant. She was treated by steroid pulses, plasmapheresis, and rituximab. Liver enzymes returned to within normal range 18 d after diagnosis. Liver biopsies, at 3 and 9 mo post-transplant, showed complete resolution of AHR. We conclude that plasmapheresis should be started as soon as AHR is diagnosed, and be associated with a B-cell depleting agent. Rituximab may be considered as a first-line therapy. | Nassim Kamar Laurence Lavayssière Fabrice Muscari Janick Selves Céline Guilbeau-Frugier Isabelle Cardeau Laure Esposito Olivier Cointault Marie Béatrice Nogier Jean Marie Peron Philippe Otal Marylise Fort Lionel Rostaing | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 3 | Can Ionic Liquids Dissolve Wood? Processing and Analysis of Lignocellulosic Materials with1-n-butyl-3 -methylimidazoliumChloride显示文摘 | FORT D A REMSING R C SWATLOSKI R P | 2007 | Green Chemistry2007，9，1： | 1 |
| 4 | A high-power MEMS electric induction motor 显示文摘 | Livermore C Forte A R Lyszczarz T | 2004 | Journal of Microelectromechanical Systems2004，13，3： | 1 |
| 5 | How students see scientists: mostly male, mostly white and mostly benevolent 显示文摘 | Fort D C Varney H L | 1989 | Science and Children1989，26，8： | 1 |
| 6 | Thick soft tissue reconstruction on highly perfusive biodegradable scaffolds显示文摘 | Mandoli C Mecheri B Forte G | | 0，，02： | 1 |
| 7 | A comparison of DNA extraction methods for food analysis 显示文摘 | Pinto A I) Forte V T Guastadisegni M C | 2007 | Food Contr2007，18，： | 1 |
| 8 | Depressive symptoms lead to Impaired cellular immune response显示文摘 | Fortes C Farchi S Forastiere F | 2003 | Psyehother Psyehosom2003，72，5： | 1 |
| 9 | Effectiveness of a training programme to improve hand hygiene compliance in primary healthcare 显示文摘 | MARTIN - MADRAZO C CANADA - DORADO A SALINERO - FORT MA | 2009 | BMC Public Health2009，9，5： | 1 |
| 10 | Study on hydration layers near a hydrophilic surface in water through AFM imaging显示文摘 | Peng C Song S Fort T | 2006 | Surface and Interface Analysis2006，38，5： | 1 |
| 11 | Is aceta- zolamide effective in the treatment of diabetic macular ede- ma? A pilot study显示文摘 | GIUSTI C FORTE R VINGOLO EM GARGIULOP | 2001 | Int Ophthalmol2001，24，2： | 1 |
| 12 | Depressive symptoms lead to impaired cellular immune response显示文摘 | Fortes C Farchi S Forastiere F | 2003 | Psychother Psychosom2003，72，5： | 1 |
| 13 | SBS and SEBS block copolymers as impact modifiers for polypropylene compounds显示文摘 | Abreu F O M S Forte M M C Liberman S A | 2005 | Journal of Polymer Science2005，95，2： | 1 |
| 14 | Differential response of leaf conductance, carbon isotope discrimination and water-use efficiency to nitrogen deficiency in maritime pine and pedunculate oak plants显示文摘 | Guehl J M Fort C Ferhi A | 1995 | New Phytologist1995，131，2： | 1 |
| 15 | Stereocomplexed 8-armed poly( ethylene glycol)-poly(lactide) star block copolymer hydrogds: gelation mechanism, mechanical properties and degradation behavior 显示文摘 | Buwalda S J Calucci L Forte C | 2012 | Polymer2012，53，： | 1 |
| 16 | Technical note: Separation of indium and iron hy solvent extraction显示文摘 | Fortes M C B Benedetto J S | 1998 | Minerals Engineering:1998，11，5： | 1 |
| 17 | Effects of whole-body vi-bration training on explosive strength and postural control inyoung female athletes显示文摘 | Fort A Romero D Bagur C | 2012 | J Strength Cond Res2012，26，4： | 1 |
| 18 | Two cases of hemichoreahemiballism with nonketotic hyperglycemia: a new point of view 显示文摘 | Battistl C Forte F Rubenni E | 2009 | Neurol Sci2009，30，3： | 1 |
| 19 | Identification of potent human anti-IL-1RI antagonist antibodies显示文摘 | Fredericks ZL Forte C Capuano JM | 2004 | Protein Eng Des Sel2004，17，1： | 1 |
| 20 | Two cases of hemichorea- hemiballism with nonketotic hyperglycemia: a new point of view 显示文摘 | Battisti C Forte F Rubenni E | 2009 | Neurol Sci2009，30，： | 1 |
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