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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Analysis of the tensile strength of polyester/hybrid ramie–cotton fabric composites显示文摘 | C.Z Paiva Júnior L.H de Carvalho V.M Fonseca S.N Monteiro J.R.M d’Almeida | 2003 | Polymer Testing2003，，2： | 2 |
| 3 | Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013显示文摘 | Joseph R. Mikhael David Dingli Vivek Roy Craig B. Reeder Francis K. Buadi Suzanne R. Hayman Angela Dispenzieri Rafael Fonseca Taimur Sher Robert A. Kyle Yi Lin Stephen J. Russell Shaji Kumar P. Leif Bergsagel Steven R. Zeldenrust Nelson Leung Matthew T. D | 2013 | Mayo Clinic Proceedings2013，，4： | 2 |
| 4 | Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry 显示文摘 | Giuffrida A Rodriguez de Fonseca F Piomelli D | 2000 | Anal Biochem2000，280，1： | 1 |
| 5 | Isoflavones with supplemental calcium provide greater protection against the loss of bone mass and strength after ovariectomy compared to isoflavones alone显示文摘 | Breitman PL Fonseca D Cheung AM | 2003 | Bone2003，33，4： | 1 |
| 6 | Combined Interpolation Restoration of Land-sat Images Through FIR Filter Design Techniques显示文摘 | Fonseca L M G Prasad G S D Mascarenhas N D A | 1993 | International Journal of Remote Sensing1993，14，13： | 1 |
| 7 | Ras pathway activation in gliomas:a strategic target for intranasal administration of perillyl alcohol显示文摘 | Da Fonseca CO Linden R Futuro D | | 0，，04： | 1 |
| 8 | Bone quality: The determinants of bone strength and fragility显示文摘 | Fonseca H Moreira-Goncalves D Coriolano H J | 2014 | Sports Medicine2014，44，1： | 1 |
| 9 | Genetic characterization of Cryptosporidium parvum isolates from cattle in Portugal: animal and human implications显示文摘 | Pereira D Fonseca I Fazendeiro I | 2001 | J Eukaryot Microbiol2001，，： | 1 |
| 10 | Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes 显示文摘 | Fonseca V Schweizer A Albrecht D | 2007 | Diabetologia2007，50，： | 1 |
| 11 | Drinking water deni- trification using a novel ion-exchange membrane bioreactor 显示文摘 | Fonseca A D Crespo J G Ameida J S | 2000 | Environmental Science and Technology2000，34，9： | 1 |
| 12 | Biological and prognostic significance of interphase fluorescence in situ hy- bridization detection of chromosome 13 abnormalities (delta13) in muhiple myeloma: an eastern cooperative on- cology group study 显示文摘 | Fonseca R Harrington D Oken MM | 2002 | Cancer Research2002，62，3： | 1 |
| 13 | Addition of vilda- gliptin to insulin improves glycaemic control in type 2 diabetes 显示文摘 | Fonseca V Schweizer A Albrecht D | 2007 | Diabectologia2007，50，11： | 1 |
| 14 | Mock circulatory system for the evaluation of left ventricular assist devices, endoluminal prostheses, and vascular diseases显示文摘 | Legend re D Fonseca J Andrade A | 2008 | Artificial Organs2008，32，6： | 1 |
| 15 | Efficacy and safety of the oncedaily GLP-1 receptor agonist lixisenatide in monotherapy:a randomized,double-blind,placebo-controlled trial in patients with type 2 diabetes(Get Goal-Mono)显示文摘 | Fonseca VA Alvarado-Ruiz R Raccah D | 2012 | Diabetes Care2012，35，6： | 1 |
| 16 | Emotion under- standing in children with ADHD显示文摘 | Da Fonseca D Seguier V Santos A | 2009 | Child Psychiatry Hum Dev2009，40，： | 1 |
| 17 | Drinking water denitrification using a novel ion-exchange membrane bioreactor显示文摘 | Fonseca A D Crespo J G Almeida J S | 2000 | Environ Sci Technol2000，34，8： | 1 |
| 18 | Reactivity of carbon nanotubes:free radical generation or scavenging activity? 显示文摘 | Fenoglio I Tomatis M Lison D Muller J Fonseca A Nagy J B | 2006 | Free Radic Biol Med2006，40，： | 1 |
| 19 | Synthesis and characterization of hybrid composites based on carbon nan- otubes 显示文摘 | CANOBRE S C ALMEIDA D A L FONSECA C P eta/ | 2009 | Electrochimica Acta2009，54，： | 1 |
| 20 | Agenetic algorithm approach to minimize transmission error of automotive spur gears sets显示文摘 | FONSECA D J SHISHOO S LIM T C | 2005 | Applied Articial Intelligence2005，19，2： | 1 |
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