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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Differences in Early Osteogenesis and Bone Micro- Architecture in Anterior Lumbar lnterbody Fusion with rhBMP-2, Equine Bone Protein Extract, and Autograft显示文摘 | Foldager C | 2009 | Bone2009，45，2： | 1 |
| 3 | Increased risk for pulmonary embolism in patients with bipolar disorder 显示文摘 | Strudsholm U Johannessen L Foldager L | 2005 | Bipolar Disord2005，7，1： | 1 |
| 4 | Effects of stage of lactation,milk protein genotype and body condition at calving on protein composition and renneting properties of bovine milk显示文摘 | FOLDAGER J HERMANSEN J E | 1997 | J Dairy Res1997，64，： | 1 |
| 5 | Depression and BMI influ- ences the serum vascular endothelial growth factor level显示文摘 | EIfving Buttenschon Foldager | 2014 | Int J Neuropsychopharmacol2014，17，9： | 1 |
| 6 | Effects of stage of lactation,milk protein genotype and body condition at calving on protein composition and renneting properties of bovine milk显示文摘 | OSTERSEN S FOLDAGER J HERMANSEN E | 1997 | Journal of Dairy Research1997，64，： | 1 |
| 7 | CACNA1C ( rs1006737 ) is associated with schizophrenia 显示文摘 | Nyegaard M Demontis D Foldager L | 2010 | Mol Psychiatry2010，15，2： | 1 |
| 8 | Effect of sex and pregnancy on feed intake capacity of growing cattle 显示文摘 | INGVARTSEN K L ANDERSEN H R FOLDAGER J | 1992 | Acta Agriculturae Scandinavica Section A: Animal Science1992，42，1： | 1 |
| 9 | A novel nano-struvtured porous polycaprolactone scaffold improves hyaline cartilagerepair in a rabbit model compared to a collagen typeⅠ/Ⅲscaffold:in vitro and in vivo studies显示文摘 | Christensen BB Foldager CB Hansen OM | 2011 | Knee Surg Sports Traumatol Arthrosc2011，，： | 1 |
| 10 | Validation of suitable housekeeping genes for hypoxia-cultured human chondrocytes显示文摘 | Foldager C B Munir S Ulrik-Vinther M | 2009 | BMC Molecular Biology2009，10，1： | 1 |
| 11 | Increased risk of hypertension in patients with bipolar disorder and patients with anxiety compared to background population and patients with schizophrenia显示文摘 | JOHANNESSEN L STRUDSHOLM U FOLDAGER L | 2006 | J Affect Disord2006，95，： | 1 |
| 12 | Effect of exogenous bovine somatotropin on pubertal mammary development in heifers显示文摘 | SEJRSEN K FOLDAGER J SORENSEN M T | 1986 | Journal of Dairy Science1986，69，6： | 1 |
| 13 | Methionine and sulfur amino acid requirement in the preruminant calf 显示文摘 | Foldager J Huber J T Bergen W G | 1977 | J Dai Sci1977，60，： | 1 |
| 14 | Depression and BML influences the serum vascular endothelial growth factor level显示文摘 | Effving B Buttenschon H N Foldager L | 2014 | I nt J Neuropsychopharmacol2014，17，9： | 1 |
| 15 | Resveratrol has inhibitory effects on the hypoxia-induced inflammation and angiogenesis in human adipose tissue in vitro显示文摘 | Karina B. Cullberg Jens Olholm S?ren K. Paulsen Casper B. Foldager Martin Lind Bj?rn Richelsen Steen B. Pedersen | 2013 | European Journal of Pharmaceutical Sciences2013，，2： | 1 |
| 16 | Increased use of antibiotics in patients treated with ciozapine 显示文摘 | Nielsen J Foldager L Meyer JM | 2009 | Eur Neuropsychopharmacol2009，19，7： | 1 |
| 17 | Clinical application of ex- tracorporeal shock wave therapy in orthopedics: focused versus unfocused shockwaves 显示文摘 | Foldager CB Kearney C Spector M | 2012 | Ultrasound Med Biol2012，38，10： | 1 |
| 18 | Random variation in voluntary dry matter intake and the effect of day length on feed intake capacity in growing cattle显示文摘 | Ingvartsen K L Andersen H E Foldager J | 1992 | Acta Agric Scand1992，42，： | 1 |
| 19 | Clinical Application of Extracorporeal Shock Wave Therapy in Orthopedics: Focused versus Unfocused Shock Waves显示文摘 | Casper Bindzus Foldager Cathal Kearney Myron Spector | 2012 | Ultrasound in Medicine & Biology2012，，10： | 1 |
| 20 | A novel nano-structured porous polycaprolactone scaffold improves hyaline cartilage repair in a rabbit nxxtel compared to a collagen type I/III scaffold: in vitro and in vivo studies显示文摘 | Christensen BB Foldager CB Hansen OM | 2012 | Knee Surg Sports Traumatol Arthrosc2012，20，6： | 1 |
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