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| 1 | Phytotherapy in diabetes: Review on potential mechanistic perspectives显示文摘Diabetes mellitus(DM) is a widely spread epidemic dis ease that results from the absence of insulin, decreased secretion and/or impaired function. Since DM is a multi factorial disease, the available pharmaceuticals, despite their sensible treatment, target mostly one pathway to control hyperglycemia and encounter several side effects. Therefore, new therapeutic paradigms aim to hit several pathways using only one agent. Tradition ally, antidiabetic plants and/or their active constituents may fulfill this need. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests without digging far for the exact mode of action. Searching among the differen literature resources and various database and in view o the above aspects, the present article provides a com prehensive review on the available antidiabetic plants that have been approved by pharmacological and clini cal evaluations, and which their mechanism(s) of ac tion is assured. These plants are categorized according to their proved mode of action and are classified into those that act by inhibiting glucose absorption from in testine, increasing insulin secretion from the pancreasinhibiting glucose production from hepatocytes, or enhancing glucose uptake by adipose and muscle tissues. The current review also highlights those that mimic in their action the new peptide analogs, such as exenatide, liraglutide and dipeptidylpeptidase-4 inhibitors that increase glucagon-like peptide-1 serum concentration and slow down the gastric emptying. | Hanan S El-Abhar Mona F Schaalan | 2014 | World Journal of Diabetes2014，5，2： | 8 |
| 2 | 黑老虎木脂素化学成分及药理作用研究进展显示文摘黑老虎是一种具有药用、食用、观赏等多种价值的经济植物。黑老虎的化学成分及药理作用研究进展较快,目前已分离出200余种化合物,其中木脂素类化合物121种,具有抗炎、抗肿瘤、抗HIV、抗凝血、抗氧化、保肝等多种药理作用。现对黑老虎中木脂素类化学成分和药理作用进行综述,为黑老虎的深入开发利用提供参考。 | 孙雅慧 曹春芽 金岸 吴卫华 | 2022 | 天然产物研究与开发2022，34，3： | 4 |
| 3 | 胰岛素缓释载体材料应用研究与问题显示文摘背景:采用不同生物材料制备成微球形态作为胰岛素载体已成为研究热点。目的:总结胰岛素缓释微球的载体材料及制备方法。方法:应用计算机检索万方数据库和Pub Med数据库1997至2015年检索有关胰岛素缓释载体材料的文献,检索关键词为'胰岛素,缓释载体,生物材料,Insulin,Controlled-release Carrier,Biomaterials'。结果与结论:天然生物可降解高分子材料,包括明胶、海藻酸盐、壳聚糖及其衍生物等是胰岛素缓释微球载体的首选材料,具有良好的生物相容性、可降解性、成膜性或成球性好。人工合成生物可降解高分子作为载体材料,具有提高药物稳定性和有效利用率、实现药物靶向输送功能。根据不同材料的理化性质采用乳化-化学交联法、喷雾干燥法、溶剂挥发法等技术可制备符合不同要求的胰岛素缓释载体,为开发安全的药物载体提供了一条新途径。 | 陈国昌 高红 | 2016 | 中国组织工程研究2016，20，30： | 1 |
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