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| 1 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 2 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 3 | Questionnaire on the perceptions of patients about shoulder surgery显示文摘 | Fitzpatrick R Carr A | 1996 | J Bone Joint Surg(Br)1996，78，： | 1 |
| 4 | Soy isoflavone:are they useful in menopause?显示文摘 | Vincent A Fitzpatrick LA | 2000 | Mayo Clin Proc2000，7，5： | 1 |
| 5 | Dermal hydrofluoric acid burns resulting in death显示文摘 | Gubbay A D Fitzpatrick R I | 1997 | Aust N Z J Surg1997，67，5： | 1 |
| 6 | Acidic fibroblast growth factor accelerates the healing of acetic-acid-induced gastriculcers in rats 显示文摘 | FITZPATRICK L R JAKUBOWSKA A Martin G E | 1992 | Digestion1992，53，12： | 1 |
| 7 | Metabolic relations to temperatures in the copepods Diaptomus dorsalis and Mesocyclopes edax from North-Central Texas显示文摘 | Smith G A Fitzpatrick L C Pearson W D | | 0，，： | 1 |
| 8 | The assessment of shoulder instability:the development and validation of a questionnaire显示文摘 | Fitzpatrick R Carr A | 1999 | J Bone Joint Surg(Br)1999，81，： | 1 |
| 9 | Tilting towards in recurrent unexplained syncope显示文摘 | Fitzpatrick A Suttuon R | 1989 | Lancet1989，1，： | 1 |
| 10 | Parents' needs following identification of childhood hearing loss 显示文摘 | Fitzpatrick E Angus D Durieux-Smith A | 2008 | Am J Audiol2008，17，1： | 1 |
| 11 | The London Millennium Footbridge 显示文摘 | Dallard P Fitzpatrick A J Flint A | 2001 | TheStructural Engineer2001，79，22： | 1 |
| 12 | Airway glutathione homeostasis is altered in children with severe asthma:Evidence for oxidant stress显示文摘 | Fitzpatrick A M Teague W C Holguin F | 2009 | Allergy Clin Immunol2009，123，1： | 1 |
| 13 | MHC class Ⅱ expression in the bovine mammary gland显示文摘 | Fitzpatrick J L P J Cripps A W Hill | 1992 | Veterinary Immunology Immunopathology1992，32，： | 1 |
| 14 | Incidence of congenital cytomegalovirus infection in Ireland: implication for screening and diagnosis显示文摘 | Waters A Jennings K Fitzpatrick E | 2014 | J Clin Virol2014，59，3： | 1 |
| 15 | Growth of impatients‘Accent Red’in three compost products显示文摘 | Klock K A Fitzpatrick G E | 1997 | Compost Science and Utilization1997，5，4： | 1 |
| 16 | Model ing water release and absorption in soils using cel ular automata显示文摘 | Aitkenhead M J Foster A R FitzPatrick E A | | 0，，220： | 1 |
| 17 | Positive emotions in psychotherapy theory,research,and practice:New kid on the block?显示文摘 | Stalikas A Fitzpatrick MR | 2008 | J Psychother Integrat2008，18，2： | 1 |
| 18 | Medullar endocrine and genetic mecha- nism of arterial calcification显示文摘 | DOHERTY T M FITZPATRICK L A INOUE D | 2004 | Endocr Rev2004，25，4： | 1 |
| 19 | Quality of life assessment:can we keep it simple?显示文摘 | Cox D R Fitzpatrick R Fletcher A E | 1992 | J R Statist Soc1992，155，： | 1 |
| 20 | Crayfish molecular systematics: inferences using a combination of proce?dures to estimate phylogeny显示文摘 | Crandall K A Fitzpatrick J J R | 1996 | Syst Biol1996，45，1： | 1 |
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