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| 1 | Sulforaphane Protects Astrocytes Against Oxidative Stress and Delayed Death Caused by Oxygen and Glucose Deprivation显示文摘氧化应激是缺血再灌注后星形胶质细胞损伤和死亡的重要分子机制之一,可能成为有效的干预靶点。下述治疗策略可减轻缺血再灌注条件下产生的多种反应性氮氧化合物损伤。这种方法可通过使用化学试剂或适当条件促进转录活化因子NRF2从细胞浆转入细胞核,并与抗氧化基因反应位点结合,来诱导缺血再灌注后损伤细胞的Ⅱ期基因反应。本研究将验证如下假说:NRF2基因表达通路激活剂sulforaphane能对体外无氧无糖环境处理的培养皮质星形胶质细胞起神经保护作用。将皮质星形胶质细胞暴露于无氧无糖环境(OGD)4 h,于干预前48 h或干预后给予5μMsulforaphane(NRF2基因表达通路激活剂)培养48 h,两种培育条件下细胞死亡均明显减少。免疫细胞化学结果表明干预前给予sulforaphane处理,细胞中DNA/RNA氧化标志物8-hydroxy-2-deox-yguanosine的表达在恢复给氧4 h后降低,两种培育条件下胞浆内及胞核内NRF2的免疫反应均增强且NQO1(NRF2转录活化基因产物)的表达和酶活性均增强。本研究提示sulforaphane可通过激活NRF2抗氧化基因表达通路,减少体外缺氧再灌注后星形胶质细胞的死亡。 | CAMELIA A.DANILOV KRISH CHANDRASEKARAN JENNIFER RACZ LUCIAN SOANE CAROL ZIELKE AND GARY FISKUM | 2009 | 神经损伤与功能重建2009，4，2： | 12 |
| 2 | Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary显示文摘 | Schuh R A Fiskum 3 | 2006 | Toxicol App Pharmacol2006，216，： | 1 |
| 3 | Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs显示文摘 | Rosenthal RE Bogaert YE Fiskum G | 2005 | Neurosci Lett2005，378，1： | 1 |
| 4 | Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury显示文摘 | Starkov AA Chinopoulos C Fiskum G | 2004 | Cell Calcium2004，36，34： | 1 |
| 5 | Calpeptin-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein(CREB)显示文摘 | Schuh RA Kristian T Fiskum G | 2005 | J Neurochem2005，92，2： | 1 |
| 6 | Calcium induced release of mitochondrial cytochrome C by different mechanisms selective for brain versus liver显示文摘 | Andreyev A Fiskum G | 1999 | Cell Death Differ1999，6，9： | 1 |
| 7 | Mechanisms of neuronal death and neuroprotection 显示文摘 | Fiskum G | 2004 | J Neurosurg Anesthesiol2004，16，： | 1 |
| 8 | Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment显示文摘 | Hoffman GE Moore N Fiskum G | 2003 | Exp Neurol2003，182，1： | 1 |
| 9 | Preconcentration and analysis of strontium-90 and technetium-99 from Hanford groundwater using solid phase extraction显示文摘 | Fiskum S K | 2000 | J Radioanal Nucl Chem2000，245，2： | 1 |
| 10 | Hyporoxic reperfusion after global ischemia decreases hippocampal energy metabolism显示文摘 | Richards EM Fiskum G Rosenthal RE | 2007 | Stroke2007，38，5： | 1 |
| 11 | Bcl-2 protects neural cells from cyanide/aglycemiaqnduced lipid oxidation, mito chondrial injury,and loss of viability显示文摘 | Myers K M Fiskum G Liu Y | 1995 | J Neurochem1995，65，6： | 1 |
| 12 | Neuroprotective effects of acetyl-L-carnitine after stroke in rats显示文摘 | Lolic MM Fiskum G Rosenthal RE | 1997 | Ann Emerg Med1997，29，6： | 1 |
| 13 | Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrest显示文摘 | Balan IS Fiskum G Hazehen J | 2006 | Stroke2006，37，12： | 1 |
| 14 | Acti- nide sequestration using self-assembled monolayers on mesoporous supports 显示文摘 | FRYXELL G E LIN Ying FISKUM S | 2005 | Environmental Science Technology2005，39，5： | 1 |
| 15 | Mitochondria in neurodegeneration: bioenergetic function in cell life and death显示文摘 | Murphy A N Fiskum G Beal M F | 1999 | J Cereb Blood Flow Met1999，19，3： | 1 |
| 16 | Mitochondria in neurodegeneration:bioenergetic function in cell life and death显示文摘 | Murphy N Fiskum G Beal MF | | 0，，03： | 1 |
| 17 | Mitochondria in neurodegeneration:acute ischemia and chronic neurodegenerative diseases显示文摘 | Fiskum G Murphy AN Flint B | | 0，，04： | 1 |
| 18 | Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity显示文摘 | Miljkovic-Lolic M Silbergleit R Fiskum G | 2003 | Brain Res2003，971，1： | 1 |
| 19 | Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock显示文摘 | WINTER B K FISKUM G GALLO L L | 1995 | British Journal Cancer1995，72，： | 1 |
| 20 | Non-NMDA glutamate receptor binding in canine brain after global cerebral ischemia and reperfusion 显示文摘 | Wei H Fiskum G Rosenthal RE | 1996 | Mol Chem Neuropathol1996，29，1： | 1 |
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