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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 3 | Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: A randomized, double-blind, placebo-controlled trial显示文摘 | Paul Rutgeerts Gert van Assche Séverine Vermeire Geert D’Haens Filip Baert Maja Noman Isolde Aerden Gert de Hertogh Karel Geboes Martin Hiele Andre D’Hoore Freddy Penninckx | 2005 | Gastroenterology2005，，4： | 2 |
| 4 | Surface algorithms using bounds on derivatives显示文摘 | Filip D Magedson R Markot R | 1986 | Computer Aided Geometric Design1986，3，2： | 2 |
| 5 | Characterization of the denitrifying fraction of phosphate accumulating organisms in biological phosphate removal显示文摘 | Meinhold J Filipe C D M Daigger G T | 1999 | War Sci Technol1999，39，1： | 1 |
| 6 | Characterization of the denitrifying fraction of phosphate accumulating organisms in biological phosphate removal显示文摘 | Meinhold J Filipe C D M Daigger G T | 1999 | Water Science and Technology1999，39，1： | 1 |
| 7 | Conversion from B4zier rectangles to B4zier triangles显示文摘 | Goldman R Filip D | 1987 | Computer Aided Design1987，19，1： | 1 |
| 8 | Evaluation of possible tourniquet systems for use in the Canadian Forces显示文摘 | King R B Filips D Blitz S | 2006 | J Trauma2006，60，5： | 1 |
| 9 | Surface algorithm u-sing bounds on derivatives显示文摘 | Filip D Magedson R Markot R | | 0，，04： | 1 |
| 10 | pH as a key factor in the competition between glycogen-accumulating organisms and phosphorus-accumulating organisms显示文摘 | Filipe Carlos D M Daigger Glen GradyT C P Leslie | 2001 | Water Environment Research2001，73，2： | 1 |
| 11 | A metabolic model for acetate uptake under anaerobic con- ditions by glycogen accumulating organisms: stoichiom- etry, kinetics, and the effect of pH 显示文摘 | FILIPE C D M DAIGGER G T GRADYC PL | 2001 | Biotechnology and Bioengineering2001，76，： | 1 |
| 12 | Characterization of the denitrifying fraction of phosphate accumulating organisms in biological phosphate removal显示文摘 | Meinhold J Filipe C D M Daigger G T | 1999 | Water Science & Technology1999，39，1： | 1 |
| 13 | Effects of pH on the rates of aerobic metabolism of phospho- rus-accumulating and glycogen-accumulating organ- isms显示文摘 | FILIPE C D M DAIGGER G T GRADY C P L | 2001 | Water Environment Research2001，73，： | 1 |
| 14 | Stoichiometry and kinetics of acetate uptake under anaerobic conditions by an enriched culture of phosphorus-accumulating organisms at different pHs显示文摘 | FILIPE C D M DAIGGER G T GRADY C P L | 2001 | Biotechnology Bioengineering2001，76，1： | 1 |
| 15 | Characterization of the denitrifying fraction of phosphate accumulating organisms in brological phosphate removal process显示文摘 | Meinhold J Filipe C D M Dagger G T | 1999 | Wat Sci-Tech1999，39，1： | 1 |
| 16 | The effect of wheat malting on the colloidal haze of white beers显示文摘 | FILIP D FLORIS JC FREDDY RD | 2004 | Teeh Q Master brew Assoe Am2004，41，1： | 1 |
| 17 | Ozonation of a landfill leachate: evaluation of toxicity removal and biode gradability improvement显示文摘 | BILA D M FILIPE M A SILVA A C | 2005 | Journal of Hazardous Materi als2005，117，2： | 1 |
| 18 | Oxidative desulufrization:Oxidation reactivity of sulfur compounds in different organic matrixes显示文摘 | Filips P D Searsella M | 2003 | Energy Fuels2003，17，6： | 1 |
| 19 | Effects of problem-based learning:a meta-analysis显示文摘 | Filip D Mien S Piet Van den B | 2003 | Learning and Instruction2003，13，5： | 1 |
| 20 | Rapid and efficient protein enzymatic digestion:An experimental comparison显示文摘 | Filip D Pavel B Karel M | | 0，，： | 1 |
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