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| 1 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 2 | Long-term survival of a patient after resection of a gastrointestinal stromal tumor arising from the pancreas显示文摘BACKGROUND:Gastrointestinal stromal tumors (GISTs) may arise in any part of the gastrointestinal tract;extragastrointestinal locations are extremely rare.Only a few cases of extragastrointestinal stromal tumor arising from the pancreas were reported.None of the reports described a long-term follow-up of the patients.METHOD:This report describes an interesting and unusual case of GIST arising from the pancreas.RESULTS:A 74-year-old female presented with a palpable abdominal mass.CT scan showed a large mass 11×8×4 cm originating from the tail of the pancreas.Percutaneous biopsy revealed a GIST predominantly with spindle cells,but some parts also contained epitheloid cells.The patient was treated by distal pancreatic resection with splenectomy.Immunohistochemistry of the tumor showed a staining pattern characteristic of GIST.The patient has achieved a long-term survival of five years and six months without any sign of recurrence of the disease.CONCLUSION:This is the first reported case of an extragastrointestinal stromal tumor arising from the pancreas treated surgically,with a long-term survival. | Filip eka Bohumil Jon Alexander Ferko Zdeněk ubrt Dimitar H Nikolov Věra Tyová | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 3 |
| 3 | Surgical Technique in Distal Pancreatectomy: A Systematic Review of Randomized Trials显示文摘 | Filip ?e?ka Bohumil Jon Zdeněk ?ubrt Alexander Ferko Masahiko Hirota | 2014 | BioMed Research International2014，，： | 2 |
| 4 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 5 | Effects of serotonin (5 -HT) (1B) receptor ligands on cocaine-seeking behavior in rats 显示文摘 | Przeglinski E Golda A Filip M | 2008 | Phannacol Rep2008，60，6： | 1 |
| 6 | An expeditious method for the determination of organochlorine pesticides residues in estuarine sediments using microwave assisted pre-extraction and automated headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry 显示文摘 | Pedro N C Pedro N R Filipe A Rafael E Maria C P Teresa M V | 2008 | Talanta2008，76，5： | 1 |
| 7 | Hyperhomocysteinemia is an indicator of oxidant stress显示文摘 | Albu E Filip C Zamosteanu N | 2012 | Med Hypotheses2012，78，4： | 1 |
| 8 | General Practitioners’ Knowledge, Attitudes, Beliefs, and Practices in the Management of Sexual Dysfunction—Results of the Portuguese SEXOS Study显示文摘 | Violeta Alarc?o Sofia Ribeiro Filipe Le?o Miranda Mário Carreira Teresa Dias Joaquim Garcia e Costa Alberto Galv?o‐Teles | 2012 | The Journal of Sexual Medicine2012，，： | 1 |
| 9 | Total polyphenol content and antioxidant capacity of commercially available tea in Argentina显示文摘 | Anesini C Ferraro G E Filip R | 2008 | J Agric Food Chem2008，56，19： | 1 |
| 10 | VOCAL TRAIT EVOLUTION IN A GEOGRAPHIC LEAPFROG PATTERN: SPECIATION IN THE MAROON-CHINNED FRUIT DOVE (PTILINOPUS SUBGULARIS) COMPLEX FROM WALLACEA显示文摘 | Rheindt Frank E Eaton James A Verbelen Filip | 2011 | The Wilson Journal of Ornithology2011，，： | 1 |
| 11 | Design of novel poly(methyl vinyl ether) containing AB and ABC block eopolymers by the dual initiator strategy显示文摘 | Katrien V Bernaerts Filip E Du Prez | 2005 | Polymer2005，46，： | 1 |
| 12 | Metabotropic glutamatergic receptors and their ligands in drug addiction显示文摘 | Pomierny-Chamioo L Rup K Pomierny B Niedzielska E Kalivas PW Filip M | 2014 | Pharmacol Ther2014，142，3： | 1 |
| 13 | Immune response to Helicobacter pylori infection and gastric cancer development显示文摘Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(H.pylori)infection is the main risk factor for its occurrence.Of note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this setting.The development of an inflammatory process against H.pylori involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial cells.This process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper cells.Cytokines released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ways.Moreover,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its receptor.In addition,various repercussions related to some H.pylori virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis. | Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália Oliveira e Silva Fabrício Freire de Melo | 2021 | World Journal of Meta-Analysis2021，9，3： | 1 |
| 14 | Effects of GABAB receptor ligands in animal tests of depressionand anxiety 显示文摘 | Frankowska M Filip M Przegalinski E | 2007 | Pharmacol Rep2007，59，： | 1 |
| 15 | Thermo-responsive and: emulsifying properties of poly (N-vinylcaprolactam) based graft copolymers显示文摘 | Verbrugghe S Bernaerts K Filip E | 2003 | Macromolecular Chemistry and Physics2003，204，9： | 1 |
| 16 | The effects of N-acetylcysteine on cocaine reward and seeking behaviors in a rat model of depression显示文摘 | Frankowska M Jastrzbska J Nowak E Biako M Przegali'nski E Filip M | 2014 | Behav Brain Res2014，266，： | 1 |
| 17 | Abdominal vtuberculosis-a surgical reality显示文摘 | Trcoveanu E Filip V Moldovanu R | 2007 | Chirurgia ( Bucur )2007，102，3： | 1 |
| 18 | The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae 显示文摘 | Filipe SR Severina E Tomasz A | 2002 | Proc Natl Acad Sci USA2002，99，3： | 1 |
| 19 | Disruption of circadian coordination and malignant growth 显示文摘 | Filip ski E Li XM Levi F | 2006 | Cancer Causes Control2006，17，50： | 1 |
| 20 | The human umbilical cord tissue-derived MSC population UCXpromotes early motogenic effects on keratinocytes and fibroblasts and G-CSF-mediated mobilization of BM-MSCs when transplanted in vivo显示文摘 | Miranda J P Filipe E Fernandes A S | 2015 | Cell Transplant2015，24，5： | 1 |
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