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| 1 | Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation显示文摘航线发炎是许多呼吸障碍的特点,例如气喘和膀胱的纤维变性。在发炎触发的航线基因表示的变化在这些疾病的致病起一个关键作用。基因连接研究建议 ESE-2 和 ESE-3,编码上皮特定的 Ets-domain-containing 抄写因素,是候选人气喘危险性基因。我们这里报导 et 家庭抄写因素 ESE-1 的另一个成员的表示,以及 ESE-3,起来在支气管的上皮的房间线由煽动性的 cytokines interleukin-1beta (IL-1beta ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 调整了。有 IL-1beta 和 TNF-alpha 的这些房间的处理为 ESE-1 和 ESE-3 导致了信使 rna 表示的戏剧的增加。我们证明导致的表示被抄写因素 NF-kappaB 的激活调停。我们描绘了 ESE-1 和 ESE-3 倡导者并且识别了为导致 cytokine 的表达式被要求的 NF-kappaB 有约束力的序列。另外,我们也表明那 ESE-1 在上面调整 ESE-3 表示, down 由 cytokines 调整它的自己的正式就职。最后,我们在 Elf3 显示出那(对人的 ESE-1 相应) 猛烈老鼠,煽动性的 cytokine interleukin-6 (IL-6 ) 的表示是调整的 down。我们的调查结果建议 ESE-1 和 ESE-3 在航线发炎起一个重要作用。 | Jing Wu Rongqi Duan Huibi Cao Deborah Field Catherine M Newnham David R Koehler Noe Zamel Melanie A Pritchard Paul Hertzog Martin Post A Keith Tanswell Jim Hu | 2008 | Cell Research2008，18，6： | 6 |
| 2 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 3 | Enhancement effects on quality characteristics of pork derived from pigs of various commercial genetic backgrounds显示文摘 | Brewer M S Sosnicki A Field B | 2004 | Journal of Food Science2004，69，1： | 1 |
| 4 | Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30 显示文摘 | Revankar C M Mitchell H D Field A S | 2007 | ACS Chem Biol2007，2，8： | 1 |
| 5 | Primary and repeat surgical treatment for female pelvic organ prolapse and incontinence in parous women in the UK: a register linkage study显示文摘 | Abdel-Fattah M Familusi A Fielding S | 2011 | BMJ Open2011，1，00： | 1 |
| 6 | The Effects of Cue-Specific Inhibition Training on Alcohol Consumption in Heavy Social Drinkers 显示文摘 | JONES A FIELD M | 2013 | Experimental and Clinical Psychopharmacology2013，21，1： | 1 |
| 7 | Relationships between NDVI,canopy structure,and photosynthesis in three Californian vegetation types显示文摘 | GAMON J A FIELD C B GOULDEN M L | | 0，，01： | 1 |
| 8 | Quantitative determination of fluorinated alkyl substances by large-volume-injection liquid chromatography tandem mass spectrometry-characterization of municipal wastewaters 显示文摘 | Schultz M M Barofsky D F Field J A | 2006 | Environment Science Technology2006，40，： | 1 |
| 9 | Oxidation of anthracene and benzo pyrene by laccases from Trametes versicolor 显示文摘 | COLLINS P J KOTTERMAN M J J FIELD J A | 1996 | Appl Environ Microbiol1996，62，12： | 1 |
| 10 | The purification and N terminal amino acid sequence analysis of the high molecular weight gluten polypeptides of wheat 显示文摘 | Shewry P R Field J M Faulks A J | 1984 | Biochimica et Bio physica Acta1984，788，： | 1 |
| 11 | Aging and stress-induced changes in complement activation and neutrophil mobilization显示文摘 | Cannon J G Fiatarone M A Fielding R A | 1994 | J Appl Physiol1994，76，6： | 1 |
| 12 | Bkm minisatellite sequences are not sex associated but reveal DNA fingerprint polymorphisms in rainbow trout显示文摘 | Lloyd M A Fields M J and Thorgard G H | 1989 | Genome1989，，32： | 1 |
| 13 | preimplantation genetic diagnosis for spinal muscular atrophy type I 显示文摘 | Fallon L Harton GL Sisson ME Rodriguez E Field LK Fugger EF Geltinger M Sun Y Dorfmann A Schoener C Bick Dm Schulman J Levinson G Black SH | 1999 | Neurology1999，53，： | 1 |
| 14 | Relationships between NDVI, canopy structure, and photosynthesis in three Californian vegetation types 显示文摘 | Gamon J A Field C B Goulden M L | 1995 | Ecological Applications1995，5，1： | 1 |
| 15 | Moving forward with strengthening routine immunization delivery as part of measles and rubella elimination activities显示文摘 | Fields R Dabbagh A Jain M | | 0，，2： | 1 |
| 16 | Recurrent thrombo embolismin patients with vena cava filters显示文摘 | Green field L J Proctor M C Mich A A | 2001 | J Vasc Surg2001，33，3： | 1 |
| 17 | Teaching Senior Oneologists Communication Skills : Results From Phase I of a Comprehensive Longi- tudinal Program in the United Kingdom显示文摘 | Fallow field L Lipkin M Hall A | 1998 | Journal of Clinical On- cology1998，16，5： | 1 |
| 18 | Rate of combustion of size-graded fractions of char from a low rank coal between 1200K-2000K显示文摘 | FIELD M A | 1969 | Combust Flame1969，13，： | 1 |
| 19 | The protective effect of antioxidants to a phototoxin-sensitive insect herbivore显示文摘 | ACION R R FIELDS P LEWIS M A | 1990 | Manduca Sexta J Chem Ecol1990，16，10： | 1 |
| 20 | Highly efficient Nd : YVO4 diode-laser end-pumped laser 显示文摘 | Field R A Birnbaum M Fincher C L | 1987 | Appl Opt Lett1987，51，23： | 1 |
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