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| 1 | Neo-adjuvant chemo(radio)therapy in gastric cancer: Current status and future perspectives显示文摘In the last 20 years, several clinical trials on neoadjuvant chemotherapy and chemo-radiotherapy as a therapeutic approach for locally advanced gastric cancer have been performed. Even if more data are necessary to define the roles of these approaches, the results of preoperative treatments in the combined treatment of gastric adenocarcinoma are encouraging because this approach has led to a higher rate of curative surgical resection. Owing to the results of most recent randomized phase III studies, neoadjuvant chemotherapy for locally advanced resectable gastric cancer has satisfied the determination of level I evidence. Remaining concerns pertain to the choice of the optimal therapy regimen, strict patient selection by accurate pre-operative staging, standardization of surgical procedures, and valid criteria for response evaluation. New well-designed trials will be necessary to find the best therapeutic approach in pre-operative settings and the best way to combine old-generation chemotherapeutic drugs with new-generation molecules. | Alberto Biondi Maria C Lirosi Domenico D'Ugo Valeria Fico Riccardo Ricci Francesco Santullo Antonia Rizzuto Ferdinando CM Cananzi Roberto Persiani | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 2 | Early gastric cancer:A challenge in Western countries显示文摘Early gastric cancer(EGC)is an invasive carcinoma involving only the stomach mucosa or submucosa,independently of lymph node status.EGC represents over 50%of cases in Japan and in South Korea,whereas it accounts only for approximately 20%of all newly diagnosed gastric cancers in Western countries.The main classification systems of EGC are the Vienna histopathologic classification and the Paris endoscopic classification of polypoid and non-polypoid lesions.A careful endoscopic assessment is fundamental to establish the best treatment of EGC.Generally,EGCs are curable if the lesion is completely removed by endoscopic resection or surgery.Some types of EGC can be resected endoscopically;for others the most appropriate treatment is surgical resection and D2 lymphadenectomy,especially in Western countries.The favorable oncological prognosis,the extended lymphadenectomy and the reconstruction of the intestinal continuity that excludes the duodenum make the prophylactic cholecystectomy mandatory to avoid the onset of biliary complications. | Maria Michela Chiarello Valeria Fico Gilda Pepe Giuseppe Tropeano Neill James Adams Gaia Altieri Giuseppe Brisinda | 2022 | World Journal of Gastroenterology2022，28，7： | 3 |
| 3 | Therapeutic strategies in Crohn’s disease in an emergency surgical setting显示文摘Crohn’s disease(CD)remains a chronic,incurable disorder that presents unique challenges to the surgeon.Multiple factors must be considered to allow development of an appropriate treatment plan.Medical therapy often precedes or complements the surgical management.The indications for operative management of CD include acute and chronic disease complications and failed medical therapy.Elective surgery comes into play when patients are refractory to medical treatment if they have an obstructive phenotype.Toxic colitis,acute obstruction,perforation,acute abscess,or massive hemorrhage represent indications for emergency surgery.These patients are generally in critical conditions and present with intra-abdominal sepsis and a preoperative status of immunosuppression and malnutrition that exposes them to a higher risk of complications and mortality.A multidisciplinary team including surgeons,gastroenterologists,radiologists,nutritional support services,and enterostomal therapists are required for optimal patient care and decision making.Management of each emergency should be individualized based on patient age,disease type and duration,and patient goals of care.Moreover,the recurrent nature of disease mandates that we continue searching for innovative medical therapies and operative techniques that reduce the need to repeat surgical operations.In this review,we aimed to discuss the acute complications of CD and their treatment. | Maria Michela Chiarello Gilda Pepe Valeria Fico Valentina Bianchi Giuseppe Tropeano Gaia Altieri Giuseppe Brisinda | 2022 | World Journal of Gastroenterology2022，28，18： | 2 |
| 4 | Comparative phytochemical and morphological analyses of three Italian Primula species显示文摘 | FICO G RODONDI G FLAMINI G | 2007 | Phytochemistry2007，68，12： | 1 |
| 5 | Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model:a major role for CD4+ CD25+ Foxp3+ T ceils independent of interleukin-10显示文摘 | Pacífico LG Marinho FA Fonseca CT | | 0，，01： | 1 |
| 6 | Miniaturi zation and geometry optimization of a polymerbased rectilinear ion trap显示文摘 | FICO M YU M OUYANG Z | 2007 | Analytical Chemis try2007，79，21： | 1 |
| 7 | The influence of excess lysine on urea cycle operation and pyrimidine biosynthesis 显示文摘 | Fico M E Hassan A S Milner J A | 1982 | The Journal of Nutrition1982，112，10： | 1 |
| 8 | The influence of excess lysine on urea cycle operation and pyrimidine biosynthesis 显示文摘 | Fico M E Hassan A S Milner J A | 1982 | J Nutr1982，112，： | 1 |
| 9 | Phenolic derivatives from Nigella damascene Seeds显示文摘 | Fico G Braca A Tome F | 2000 | Pharm Boil2000，38，5： | 1 |
| 10 | Food habits of wolves in central Italy based on stomach and intestine analyses 显示文摘 | Pezzo F Parigi L Fico R | 2003 | Acta Theriologica2003，48，： | 1 |
| 11 | Design, micro-fabrication, and a- nalysis of micrometer-sized cylindrical ion trap arrays显示文摘 | Cruz D Chang J P Fico M | 2007 | Review of Scientific Instruments2007，78，01： | 1 |
| 12 | Polymer-based ion trap chemical sensor显示文摘 | Yu M Fico M Kothari S | 2006 | Sensors Journal IEEE2006，6，6： | 1 |
| 13 | Assessment of Eurocode-like design equations for the shear capacity of FRP RC members显示文摘 | FICO R PROTA A MANFREDI G | 2008 | Composites Part B : Engineering2008，39，5： | 1 |
| 14 | Transient Marangoni convection in hanging evaporating drops显示文摘 | Savino R Fico S | | 0，，10： | 1 |
| 15 | The interaction between drops and solidification front in presence of Marangoni effect显示文摘 | Nota F Savino R Fico S | | 0，，： | 1 |
| 16 | Food habits of wolves in central Italy based on stomach and intestine analyses显示文摘 | Pezzo F Parigi L Fico R | 2003 | Acta Theriologica2003，48，2： | 1 |
| 17 | Co-administration of plasmid expressing IL-12 with 14-kDa Schistosoma mansoni fatty acid-binding protein cDNA alters immune response profiles and fails to enhance protection induced by Sm14 DNA vaccine alone显示文摘 | Cristina T. Fonseca Lucila G.G. Pacífico Michele M. Barsante Tatiana Rassi Geovanni D. Cassali Sérgio. C. Oliveira | 2006 | Microbes and Infection2006，，9： | 1 |
| 18 | Miniaturi- zation and geometry optimization of a polymer based rectilinear ion trap 显示文摘 | FICO M YU M OUYANG Z | 2007 | Analytical Chemis- try2007，79，21： | 1 |
| 19 | Human antibody re sponses of patients living in endemic areas for schistosomiasis to the tegumental protein Sm29identified through genomic studies显示文摘 | Cardoso FC Pacífico RN Mortara RA | 2006 | Clin Exp Immunol2006，144，3： | 1 |
| 20 | Antioxidant and free radical scavenging of flavonol glycosides from different Aconitum species显示文摘 | Braca A Fico G Morelli I | 2003 | Journal of Ethnopharmacology2003，86，： | 1 |
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