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| 1 | PLEIOTROPIC REGULATORY LOCUS 1 (PRL1) Integrates the Regulation of Sugar Responses with Isoprenoid Metabolism in Arabidopsis显示文摘在植物房间的 isoprenoids 的生合成从 mevalonate (MVA ) 在 cytosol 生产的先锋发生小径并且在由 methylerythritol 4 磷酸盐(MEP ) 的质体,小径,而是很少对协调两条小径的机制被知道。在 Arabidopsis thaliana 为如此的协作发信号的糖的重要性的证据被没有变化,在相关 MEP 小径抄本,蛋白质,或酶活动的层次显示出导出 MEP 的 isoprenoid 产品(叶绿素和类胡萝卜素) 的增加的累积的异种的描述这里提供。这异种被发现是新 loss-of-function 等位基因 PRL1 (多种的规章的地点 1 ) ,编码作为糖的一个全球管理者工作的保存 WD 蛋白质的基因,应力,和荷尔蒙回答,部分地由 SNF1 相关的蛋白质 kinases (SnRK1 ) 的抑制。与在 MVA 小径的主要的规章的酶的 phosphorylation 和 inactivation 的 SnRK1 kinases 的报导角色一致(hydroxymethylglutaryl 辅酶 -- reductase ) ,它的活动或蛋白质层次在 prl1 幼苗被减少。然而,导出 MVA 的结束产品(甾醇) 的累积在变异的幼苗是未改变的。蔗糖补充到野类型的幼苗 phenocopied prl1 变化以 isoprenoid 新陈代谢,建议观察 isoprenoid 显型从增加的糖累积导致 prl1 异种。在摘要, PRL1 看起来与糖,荷尔蒙,和压力回答协调 isoprenoid 新陈代谢。 | Ursula Flores-Perez Jordi Perez-Gil Marta Closa Louwrance R Wright Patricia Botella-Pavia Michael A. Phillips Albert Ferrer Jonathan Gershenzon Manuel Rodriguez-Concepcion | 2010 | Molecular Plant2010，3，1： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Transepithelial taurine transport in Caco-2 cell monolayers显示文摘 | ROIG-PóREZ S MORETó M FERRER R | 2005 | Journal of Membrane Biology2005，204，： | 1 |
| 4 | Only C-reactive protein,but not TNF-α or IL6,reflects the improvement in inflammation after bariatric surgery显示文摘 | Pardina E Ferrer R Baena-Fustegueras JA | | 0，，01： | 1 |
| 5 | Deteetion and identification of species of the genus Fabavirus by RT- PCR with a single pair of primers显示文摘 | Ferrer R M Luis Arteaga M Guerri J | 2007 | Journal Of VirologicalMethods2007，144，： | 1 |
| 6 | Bloodstream infection in the ICU 显示文摘 | Vall6s J Ferrer R | 2009 | Infect Dis Clin North Am2009，23，3： | 1 |
| 7 | Determination of O2 and CO2 transmission rates through microperforated films for modified atmosphere packaging of fresh fruits and vegetables显示文摘 | GONZALEZ J FERRER A ORIA R | 2008 | Journal of Food Engineering2008，86，2： | 1 |
| 8 | Ventilater associated pneurmonia:incidence,risk factors,and microbio1ogy显示文摘 | Bauer TT Ferrer R Angrill J | 2000 | Semin Respir Infect2000，15，： | 1 |
| 9 | Ultraflex precision colonic stent placement as a bridge to surgery in patients with malignant colon obstruction显示文摘 | Fregonese D Naspetti R Ferrer S | 2008 | Gastrointest Endosc2008，67，： | 1 |
| 10 | Mucosal surface area in chicken small intestine during development显示文摘 | Mitjans M Bamiol G Ferrer R | 1997 | Cell and Tissue Research1997，290，1： | 1 |
| 11 | Eco-efficiency, asset recovery and re- manufacturing 显示文摘 | Ayres R Ferrer G | 1997 | Eur Management J1997，15，5： | 1 |
| 12 | Prion protei expresion in senile plaques in Alzheimer' s disease 显示文摘 | Ferrer I Blanco R Carmona M Pnig B Ribera R Rey M J | 2001 | Acta Neuropatho12001，101，1： | 1 |
| 13 | Patterns in syntactic dependency networks显示文摘 | Ferrer I Cancho R Sole R V Kohler R | 2004 | Physical Review E2004，69，05： | 1 |
| 14 | Alien predators and amphibian declines:review of two decades of science and the transition to conservation显示文摘 | FERRER R P | 2003 | Diversity and Distributions2003，9，： | 1 |
| 15 | Genetic and physiologic dissection of the vertebrate cardiac conduction system显示文摘 | Chi N C Shaw R M Jungblut B Huisken J Ferrer T Arnaout R | 2008 | PLoS Biol2008，6，： | 1 |
| 16 | Ventilator-associated pneu- monia;incidence, risk factors, and microbiology显示文摘 | Bauer TT Ferrer R Angrill J etal | 2000 | Semin Respir Infect2000，15，4： | 1 |
| 17 | Ventilator-associated pneumonia:in- cidence, rish factors, and microbiology显示文摘 | Bauer TT Ferrer R Angrill J etal | 2000 | Se-min Respir Infect2000，15，4： | 1 |
| 18 | Capability of microalgae-based wastewater treat- ment systems to remove emerging organic contami- nants A pilot-scale study显示文摘 | MATAMOROS V GUTIERREZ R FERRER I | 2015 | Journal of Hazardous Materials2015，288，2： | 1 |
| 19 | On pricing and composi- tion of bundles显示文摘 | Bitran G R Ferrer J C | 2007 | Production and Operations management2007，16，1： | 1 |
| 20 | Plinabulin 显示文摘 | FERRER E BOLOS J CASTANER R | 2010 | Drugsof the Future2010，35，1： | 1 |
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