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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Managing New and Remanufaetured Products 显示文摘 | Ferrer G Swarninathan JM | 2006 | Management Science2006，52，1： | 1 |
| 3 | An affine projection algorithm with variable step size and projection order 显示文摘 | GONZALEZ A FERRER M de DIEGO M PINERO G | 2012 | Digital Signal Processing2012，22，58： | 1 |
| 4 | Managing New and Differentiated Remanufactured Products显示文摘 | Ferrer G Swaminathan J M | 2010 | European Journal of Operational Research2010，203，2： | 1 |
| 5 | Managing new and remanufactured products显示文摘 | Ferrer G Swaminathan J M | 2006 | Management Science2006，52，1： | 1 |
| 6 | Managing new and remanufactured products显示文摘 | Ferrer G Swaminathan J M | 2006 | Management Science2006，52，1： | 1 |
| 7 | Application of experimental design technique to the optimization of bench-scale composting conditions of municipal raw sludge显示文摘 | Leiva M T G Casacuberta A A Ferrer A'S | 2003 | Compost Science & Utilization2003，11，4： | 1 |
| 8 | MicroRNA expres- sion in chronic lymphocytic leukemia developing autoimmune hemolytic anemia 显示文摘 | Ferrer G Navarro A Hodgson K | 2013 | Leuk Lymphoma2013，54，20： | 1 |
| 9 | Managing new and remanufactured products显示文摘 | Ferrer G Swaminathan J M | 2006 | Management Science2006，52，1： | 1 |
| 10 | Competitive Advantage through Take-back of Used Products显示文摘 | Heese H S Cattani K Ferrer G | 2005 | European Journal of Operational Research2005，164，1： | 1 |
| 11 | Managing new and remanufactured products显示文摘 | Ferrer G Swarninathan J M | 2006 | Management Science2006，52，1： | 1 |
| 12 | Mucosal surface area in chicken small intestine during development显示文摘 | Mitjans M Bamiol G Ferrer R | 1997 | Cell and Tissue Research1997，290，1： | 1 |
| 13 | Yield information and supplier responsiven-ess in remanufacturing operations显示文摘 | FERRER G | 2003 | European Journal of Operational Research2003，149，3： | 1 |
| 14 | Eco-efficiency, asset recovery and re- manufacturing 显示文摘 | Ayres R Ferrer G | 1997 | Eur Management J1997，15，5： | 1 |
| 15 | Managing new and remanufactured products显示文摘 | FERRER G SWAMINATHAN J M | 2006 | Management Science2006，52，1： | 1 |
| 16 | Managing new and remanufactured products 显示文摘 | Ferrer G Swaminathan J M | 2006 | Management Science2006，52，1： | 1 |
| 17 | The impact of remanufacturing in the economy 显示文摘 | Ferrer G Robert U | 2000 | Ecological Economics2000，32，3： | 1 |
| 18 | Managing new and differentiated remanfactured products 显示文摘 | Ferrer G | 2010 | European Journal of Operation Research2010，203，2： | 1 |
| 19 | The Economics of Tire Remanufacturing显示文摘 | Ferrer G | 1997 | Resources Conservation and Recycle1997，19，4： | 1 |
| 20 | Managing new and remanu factured products显示文摘 | Ferrer G Swaminathan J M | 2006 | Management Science2006，52，1： | 1 |
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