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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | WNT and betacatenin signalling:diseases and therapies显示文摘 | Moon R T Kohn A D De Ferrari G V | 2004 | Nature Reviews Genetics2004，5，9： | 1 |
| 4 | The ECG in pulmonary embolism: predictive value of nega rive T waves in precordial leads 80 case reports显示文摘 | FERRARI E IMBERT A CHEVALIER T | 1997 | Chest1997，11，： | 1 |
| 5 | Mea- suring internal electric fields in organic light - emitting diodes using electroabsorption spectroscopy 显示文摘 | CAMPBELL LAN H FERRARIS J P HAGLER T W | 1997 | Polym Advan Technol1997，8，： | 1 |
| 6 | Cardiac remodeling concepts and clinic implications: a consensus paper from an international forum on cardiac remodeling显示文摘 | Ferrari t Sharpe N | 2000 | JACC2000，35，： | 1 |
| 7 | Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors显示文摘 | Ferrari FK Samulski T Shank T | 1996 | J Virol1996，70，5： | 1 |
| 8 | Recent advances in the discovery of D-amino acid oxidase inhibitors and their therapeutic utility in schizophrenia显示文摘 | Ferraris DV Tsukamoto T | 2011 | Current Pharmaceutical Design2011，17，2： | 1 |
| 9 | Intravitreal triamcinolone acetonide: valuation of retinal thickness changes measured by optical coherence tomography in diffuse diabetic macular edema 显示文摘 | MICELLI FERRARI T SBORGIA L FURINO C | 2004 | Eur J Ophthalmol2004，14，4： | 1 |
| 10 | Study on the microbiological degradation of bensulfuronmethyl 显示文摘 | Brusa T Ferrari F Bolzacehini E | 2001 | Annals of Microbiology2001，51，： | 1 |
| 11 | A hidden Markov model-based stride segmentation technique applied to equine inertial sensor trunk movement data显示文摘 | Pfau T Ferrari M Parsons K | 2008 | J Biomech2008，41，1： | 1 |
| 12 | Chromogranin A in heart failure; a novel neurohumoral factor and a predictor for mortality显示文摘 | Ceconi C Ferrari R Bachetti T | 2002 | Eur Heart J2002，23，12： | 1 |
| 13 | Surface ex- pression patterns of negative regulatory molecules identify determinants of virus-specific CD8 T-cell exhaustion in HIV infection 显示文摘 | Yamamoto T Price DA Casazza JP Ferrari G Nason M Chattopadhyay PK Roederer M Gostick E Katsikis PD Douek DC Haubrich R Petrovas C Koup RA | 2011 | Blood2011，117，18： | 1 |
| 14 | Triamcinoloneassisted pars plana vitrectomy for proliferative vitreoretinopathy显示文摘 | Furino C Micelli Ferrari T Boscia F | | 0，，6： | 1 |
| 15 | Expression of the G2-M checkpoint regulators cyclinB1 and P34CDC2 in breast cancer:a correlation with cellular kinetice显示文摘 | Megha T Lazzi S Ferrari F | 1999 | Anticancer Res1999，19，1： | 1 |
| 16 | The ECG in pulmonary embolism,predictive value of negative T waves in precordial leads-80 case reports显示文摘 | Ferrari E Imbert AI Chevalier T | 1997 | Chest1997，111，3： | 1 |
| 17 | Kinetic mechanism and mierostruerure during the formation of Si3N4 matrix in Si3N4 MoSi2 composites显示文摘 | Beruto D T Ferrari A Giordani M Marino F | 2003 | Materials Science and Engineering2003，，355： | 1 |
| 18 | Silicon carbide composites as fusion power reactor structural materials显示文摘 | Snead L L Nozawa T Ferraris M | 2011 | J Nuclear Mater2011，417，13： | 1 |
| 19 | Risk factors for complications after performance of ERCP显示文摘 | Vandervoort J Soetikno R M Tham T C Wong R C Ferrari A P Jr Montes H | 2002 | Gastrointest Endosc2002，56，： | 1 |
| 20 | Tumor necrosis factor soluble eceptors in patients with various degrees of congestive heart failure显示文摘 | Ferrari R Bachetti T Confortini R | 1995 | Circulation1995，92，6： | 1 |
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