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| 1 | 急性肾损伤诊断与分类专家共识显示文摘近几十来.临床和基础的研究工作者们针对急性肾功能衰竭(ARF)进行了广泛的研究,尽管我们在该疾病的生理和发病机制方面都取得了长足的进步,但如何将这些知识用于临床,改进ARF患者预后方面的工作却做得十分有限。ARF是由多种病因导致、可发生在各种临床情况之下(儿童或成人、门诊或住院、ICU或非ICU患者)的一种复杂的肾功能紊乱,其临床表现既可以是血肌酐水平的轻微升高,也可以是无尿性肾功能衰竭。 | RL Mehta JA Kellum S Shah B Molitoris C Ronco D Warnock A Levin 王欣 | 2006 | 中华肾脏病杂志2006，22，11： | 348 |
| 2 | Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance. | Asmaa Ibrahim Gomaa Shahid A Khan Mireille B Toledano Imam Waked Simon D Taylor- Robinson | 2008 | World Journal of Gastroenterology2008，14，27： | 78 |
| 3 | TME术前短程放疗后化疗对比术前放化疗联合术后辅助化疗治疗局部晚期直肠癌(RAPIDO研究)—一项随机、开放的Ⅲ期临床试验显示文摘背景:全身复发仍然是局部晚期直肠癌患者需要面临的难题。该研究是采用短程放疗后行化疗和延迟手术对比术前诱导治疗后直接手术疗效的临床试验(the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation,RAPIDO),旨在不影响局部控制效果的前提下减少远处转移。方法:在这项多中心、随机、开放的Ⅲ期试验中,参与者来自于荷兰、瑞典、西班牙、斯洛文尼亚、丹麦、挪威和美国的共54个医学中心。纳入患者年龄在18岁及以上,ECOG评分为0~1分,且为经活检确诊局部晚期原发直肠腺癌的初诊患者,盆腔MRI评估为高危(至少符合一项标准:cT4a或cT4b,壁外血管侵犯,cN2,直肠系膜筋膜受累,或侧方淋巴结增大)。患者具备化疗适应证,并可在随机分组前5周内完成分期评估。 | 李来元 张维胜 BAHADOER R R DIJKSTRA E A VAN ETTEN B | 2021 | 结直肠肛门外科2021，27，1： | 72 |
| 4 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 5 | 前庭性偏头痛:诊断标准——Barany学会及国际头痛学会共识文件显示文摘本文提供了前庭性偏头痛的诊断标准,由Barany学会前庭疾患分类委员会及国际头痛学会(IHS)偏头痛分类分委员会共同制定。分类包括前庭性偏头痛及很可能的前庭性偏头痛。与IHS的常规程序相同,前庭性偏头痛作为一种新分类,将首先出现在第3版国际头痛分类(ICHD-3)的附录中。若积累了进一步的证据,很可能的前庭性偏头痛也许会纳入更晚的ICHD版本中。前庭性偏头痛的诊断建立在反复发作的前庭症状、具有偏头痛病史、前庭症状与偏头痛症状间存在时间上的相关性,并排除其他可导致前庭症状的病因。符合前庭性偏头痛诊断的症状包括不同类型的眩晕及头部活动诱发的头晕伴恶心。症状的严重程度必须为中重度。急性发作的持续时间限于5 min^72 h的时间窗内。 | 华驾略 李焰生 Lempert T Olesen J Furman J Waterston J Seemungal B Carey J Bisdorff A Versino M Evers S Newman-Toker D | 2013 | 神经病学与神经康复学杂志2013，10，3： | 60 |
| 6 | Probiotics and prebiotics in chronic inflammatory bowel diseases显示文摘The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). Although the etiology of IBD is not entirely understood, it is known that the chronic inflammation of Crohn’s disease, ulcerative colitis and chronic pouchitis are a result of an overly aggressive immune response to the commensal intestinal flora in genetically susceptible hosts. Recent studies have enhanced our ability to understand the interaction between the host and its intestinal microflora and the role the microflora plays in maintaining intestinal homeostasis. As we begin to understand the benefi ts conferred to the intestine by the microflora, the notion of modifying the composition of the bacterial load to improve human health has arisen. A signifi cant body of research now exists investigating the role of probiotics and prebiotics in ameliorating chronic intestinal inflammation. This article will begin with an overview of the role of the commensal microflora in maintaining mucosal immune homeostasis, and how a dysregulated immune response to the intestinal microflora results in IBD. This will be followed by a summary of the use of probiotics and prebiotics in experimental and human IBD. | Julia B Ewaschuk Levinus A Dieleman | 2006 | World Journal of Gastroenterology2006，12，37： | 41 |
| 7 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 8 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 9 | Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma显示文摘AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P < 0.0001,respectively). In contrast,the serum levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay. | Mansour S Al-Moundhri A Al-Shukaili M Al-Nabhani B Al-Bahrani IA Burney A Rizivi SS Ganguly | 2008 | World Journal of Gastroenterology2008，14，24： | 32 |
| 10 | Synthesis of core-shell acrylic-polyurethane hybrid latex as binder of aqueous pigment inks for digital inkjet printing | Jingfang Zhang a,Xuefeng Li a,Xinhao Shi a,Mei Hua a,Xingping Zhou b,Xiaqin Wang a,a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China b College of Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China | 2012 | Progress in Natural Science:Materials International2012，22，1： | 31 |
| 11 | Corrigendum to “Properties improvement of SPEEK based proton exchange membranes by doping of ionic liquids and Y_2O_3”[Prog. Nat. Sci.: Mater. Int. 22 (1) (2012) 26-30] | Jianbin Chen a, Qiang Guo a, Dan Li a, Juying Tong a,b, Xia Li a a School of Materials Science and Engineering, Shanghai University, Shanghai 201800, China b School of Wenling, Zhejiang TV University, Wenling 317500, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 33 |
| 12 | Study of BESIII trigger efficiencies with the 2018 J/ψ data显示文摘Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII detector.The efficiencies are determined from three representative physics processes,namely Bhabha scattering,dimuon production and generic hadronic events with charged particles.The combined efficiency of all active triggers approaches 100%in most cases,with uncertainties small enough not to affect most physics analyses. | M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.Chelkov D.Y.Chen G.Chen H.S.Chen M.L.Chen S.J.Chen X.R.Chen Y.B.Chen Z.J Chen W.S.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai X.C.Dai A.Dbeyssi R.E.de Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong X.Dong S.X.Du Y.L.Fan J.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng M.Fritsch C.D.Fu Y.Gao Y.Gao Y.Gao Y.G.Gao I.Garzia P.T.Ge C.Geng E.M.Gersabeck A Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu S.Gu Y.T.Gu C.Y Guan A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov T.T.Han W.Y.Han X.Q.Hao F.A.Harris H Hüsken K.L.He F.H.Heinsius C.H.Heinz T.Held Y.K.Heng C.Herold M.Himmelreich T.Holtmann Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang L.Q.Huang X.T.Huang Y.P.Huang Z.Huang T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad S.Jaeger S.Janchiv Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.B.Jiang X.S.Jiang J.B.Jiao Z.Jiao S.Jin Y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.G.Kurth W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.Li H.B.Li H.J.Li J.L.Li J.Q.Li J.S.Li Ke Li L.K.Li Lei Li P.R.Li S.Y.Li W.D.Li W.G.Li X.H.Li X.L.Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.T.Liang L.Z.Liao J.Libby C.X.Lin B.J.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.L.Liu J.Y.Liu K.Liu K.Y.Liu Ke Liu L.Liu M.H.Liu P.L.Liu Q.Liu Q.Liu S.B.Liu Shuai Liu T.Liu W.M.Liu X.Liu Y.Liu Y.B.Liu Z.A.Liu Z.Q.Liu X.C.Lou F.X.Lu H.J.Lu J.D.Lu J.G.Lu X.L.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo b P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma R.Q.Ma R.T.Ma X.X.Ma X.Y.Ma F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni Y.J.Mao Z.P.Mao S.Marcello Z.X.Meng J.G.Messchendorp G.Mezzadri T.J.Min R.E.Mitchell X.H.Mo Y.J.Mo N.Yu.Muchnoi H.Muramatsu S.Nakhoul Y.Nefedov F.Nerling I.B.Nikolaev Z.Ning S.Nisar S.L.Olsen Q.Ouyang S.Pacetti X.Pan Y.Pan A.Pathak P.Patteri M.Pelizaeus H.P.Peng K.Peters J.Pettersson J.L.Ping R.G.Ping R.Poling V.Prasad H.Qi H.R.Qi K.H.Qi M.Qi T.Y.Qi T.Y.Qi S.Qian W.-B.Qian Z.Qian C.F.Qiao L.Q.Qin X.S.Qin Z.H.Qin J.F.Qiu S.Q.Qu K.H.Rashid K.Ravindran C.F.Redmer A.Rivetti V.Rodin M.Rolo G.Rong Ch.Rosner M.Rump H.S.Sang A.Sarantsev Y.Schelhaas C.Schnier K.Schoenning M.Scodeggio D.C.Shan W.Shan X.Y.Shan J.F.Shangguan M.Shao C.P.Shen P.X.Shen X.Y.Shen H.C.Shi R.S.Shi X.Shi X.D Shi W.M.Song Y.X.Song S.Sosio S.Spataro K.X.Su P.P.Su F.F.Sui G.X.Sun H.K.Sun J.F.Sun L.Sun S.S.Sun T.Sun W.Y.Sun X Sun Y.J.Sun Y.K.Sun Y.Z.Sun Z.T.Sun Y.H.Tan Y.X.Tan C.J.Tang G.Y.Tang J.Tang J.X.Teng V.Thoren I.Uman B.Wang C.W.Wang D.Y.Wang H.J.Wang H.P.Wang K.Wang L.L.Wang M.Wang M.Z.Wang Meng Wang W.Wang W.H.Wang W.P.Wang X.Wang X.F.Wang X.L.Wang Y.Wang Y.D.Wang Y.F.Wang Y.Q.Wang Y.Y.Wang Z.Wang Z.Y.Wang Ziyi Wang Zongyuan Wang D.H.Wei P.Weidenkaff F.Weidner S.P.Wen D.J.White U.Wiedner G.Wilkinson M.Wolke L.Wollenberg J.F.Wu L.H.Wu L.J.Wu X.Wu Z.Wu L.Xia H.Xiao S.Y.Xiao Z.J.Xiao X.H.Xie Y.G.Xie Y.H.Xie T.Y.Xing G.F.Xu Q.J.Xu W.Xu X.P.Xu F.Yan L.Yan W.B.Yan W.C.Yan Xu Yan H.J.Yang H.X.Yang L.Yang S.L.Yang Y.X.Yang Yifan Yang Zhi Yang M.Ye M.H.Ye J.H.Yin Z.Y.You B.X.Yu C.X.Yu G.Yu J.S.Yu T.Yu C.Z.Yuan L.Yuan X.Q.Yuan Y.Yuan Z.Y.Yuan C.X.Yue A.Yuncu A.A.Zafar Y.Zeng B.X.Zhang Guangyi Zhang H.Zhang H.H.Zhang H.Y.Zhang J.J.Zhang J.L.Zhang J.Q.Zhang J.W.Zhang J.Y.Zhang J.Z.Zhang Jianyu Zhang Jiawei Zhang L.Q.Zhang Lei Zhang S.Zhang S.F.Zhang Shulei Zhang X.D.Zhang X.Y.Zhang Y.Zhang Y.H.Zhang Y.T.Zhang Yan Zhang Yao Zhang Yi Zhang Z.H.Zhang Z.Y.Zhang G.Zhao J.Zhao J.Y.Zhao J.Z.Zhao Lei Zhao Ling Zhao M.G.Zhao Q.Zhao S.J.Zhao Y.B.Zhao Y.X.Zhao Z.G.Zhao A.Zhemchugov B.Zheng J.P.Zheng Y.Zheng Y.H.Zheng B.Zhong C.Zhong L.P.Zhou Q.Zhou X.Zhou X.K.Zhou X.R.Zhou A.N.Zhu J.Zhu K.Zhu K.J.Zhu S.H.Zhu T.J.Zhu W.J.Zhu W.J.Zhu Y.C.Zhu Z.A.Zhu B.S.Zou J.H.Zou | 2021 | Chinese Physics C2021，45，2： | 33 |
| 13 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 14 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 15 | 囊性肾瘤、肾脏混合性上皮和间质肿瘤34例临床病理分析显示文摘 | Turbiner J Amin M B Humphrey P A 刘飞飞(摘译) 张仁亚(审校) | 2007 | 临床与实验病理学杂志2007，23，3： | 29 |
| 16 | Some open problems in granular matter mechanics显示文摘Granular matter is a large assemblage of solid particles, which is fundamentally different from any other type of matters, such as solid and liquid. Most models presented for granular matter are phenomenological and are only suitable for solving engineering problems. Many fundamental mechanical problems remain open. By analyzing characteristics of internal state structure, we propose that granular matter is intrinsically multiscale, i.e. microscale of particle size, mesoscale of force chain, and macroscale of the bulk of granular matter. The correlations among difference scales would be crucial. The mesoscale force chain network is determined by both particle properties and macroscopic boundary conditions. The evolution of the force the chain network contributes to macroscopic mechanical properties of granular matter. In addition, we discuss the drawbacks in simplifying contact forces in the current models, and the difficulties in analyzing the interaction of interstitial fluid in wet granular matter. As an appropriate application of granular matter, debris flow can be studied with granular matter mechanics; meanwhile, debris flow brings more challenges which certainly motivate future studies on granular matter. | Qicheng Sun a, Guangqian Wanga, Kaiheng Hub a Department of Hydraulic Engineering, State Key Laboratory for Hydroscience and Engineering, Tsinghua University, Beijing 100084, China b Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu 610041, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 25 |
| 17 | Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice(摘要)显示文摘 | Gao, Y Yao, A Zhang, W Lu, S Yu, Y Deng, L Yin, A Xia, Y Sun, B Wang, X | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 25 |
| 18 | 半干旱农牧交错带栗钙土的发生与演变显示文摘半干旱农牧交错带玄武岩和沙质沉积物上发育的典型草原土壤──粟钙土形成于距今6000~8000年以前。随着时间的进程,它经历了有机质积累与分解,碳酸盐淀积与淋溶,元素氧化物迁移与富集,以及风沙堆积等作用。近二百余年来,栗钙土在人为强度活动,开垦种植和过度放牧经营管理下,土壤理化性质渐趋恶化,从而反映出演变过程中的土壤退化现象。 | 刘良梧 周健民 刘多森 ИBaHOB И B ДeMКИH B A ПPиXOДbKO B E | 2000 | 土壤学报2000，37，2： | 20 |
| 19 | The precipitation strengthening behavior of Cu-rich phase in Nb contained advanced Fe-Cr-Ni type austenitic heat resistant steel for USC power plant application | Cheng-yu Chi a, Hong-yao Yu b, Jian-xin Dong b, Wen-qing Liu c, Shi-chang Cheng d, Zheng-dong Liu d, Xi-shan Xie b a School of Metallurgical and Ecological Engineering, University of Science & Technology Beijing, Beijing 100083, China b School of Materials Science and Engineering, University of Science & Technology Beijing, Beijing 100083, China c Instrumental Analysis & Research Center, Shanghai University, Shanghai 200444, China d Central Iron and Steel Research Institute, Beijing 100081, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 20 |
| 20 | 龙门山断裂带沉积岩和天然断层泥的摩擦滑动性质与启示显示文摘对采自四川龙门山断裂带(LFZ)地震发生区段的样品进行摩擦滑动实验研究,得到一系列实验结果。实验样品包括用富含黏土的完整泥岩和砂岩制备的模拟断层泥、由富含方解石的灰岩制备的模拟断层泥和一种天然断层泥。其中,天然断层泥是通过人工探槽方法采自于穿过泥岩和砂岩层的地表破裂中。富含黏土矿物的样品主要由伊利石和石英组成。在实验中,将1 mm厚的断层泥夹于具有倾斜锯切面的围岩之间,在三轴实验系统中对其进行剪切变形实验,实验条件与龙门山断裂带2 km深处的条件相一致。实验温度范围为25℃~150℃,同时为了研究摩擦强度的速度依赖性,对剪切位移的速度实施1.22~0.122μm/s的阶跃式变化。分析结果表明,天然断层泥比原岩的泥岩和砂岩更富含伊利石,而且强度比原岩弱得多。天然断层泥的稳态摩擦系数约为0.4,而原岩则约为0.6。另外,灰岩断层泥的摩擦系数为0.6~0.7。除了灰岩,所有样品均表现为稳定、速度强化的滑动行为。灰岩在25℃~50℃表现为速度强化,但是在100℃~150℃时表现为准静态的振荡,在150℃时显示速度弱化行为。运用此次实验结果讨论沉积岩在类似于汶川地震这样的地震事件中所起的作用,指出该区域富含黏土的沉积层可能对从深部扩展而来的破裂扩展有阻尼作用,而灰岩则有可能会加速破裂的传播,同时产生明显的应力降。 | 何昌荣 VERBERNE B A SPIERS C J | 2011 | 岩石力学与工程学报2011，30，1： | 20 |
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