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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Evaluation,treatment,and prevention of vitamin D deficiency:an Endocrine Society Clinical Practice Guideline显示文摘 | Holick MF Binkley NC Bischoff~Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，7： | 1 |
| 3 | Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline 显示文摘 | Holick MF Binkley NC Bischoff- Ferrari HA | 2011 | J Clin Endoerinol Metab2011，96，7： | 1 |
| 4 | Evaluation,treatment,and preven-tion of vitamin D deficiency : an Endocrine Society clinical practice guideline 显示文摘 | Holick MF Binkley NC Bischoff - Ferrari HA | 2011 | J ClinEndocrinol Metab2011，96，7： | 1 |
| 5 | Alpha2-adrenergic receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats during development显示文摘 | Carrettiero DC Ferrari MF Fior-Chadi DR | 2012 | Auton Neurosci2012，166，12： | 1 |
| 6 | Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine So- ciety clinical practice guideline显示文摘 | Holick MF Binkley NC Bischoff- Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，7： | 1 |
| 7 | Evaluation, treatment, and prevention of vitamin D deficiency :an Endocrine Society clinical practice guideline显示文摘 | Holick MF Binkley NC Bischoff -Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，7： | 1 |
| 8 | Change in the expression of NPY receptor subtypes Y1 and Y2 in central and peripheral neurons related to the control of blood pressure in rats following experimental hypertension 显示文摘 | Coelho EF Ferrari MF Maximino JR | 2004 | Neuropeptides2004，38，23： | 1 |
| 9 | Evaluation, treat- ment,and prevention of vitamin D deficiency:an endocrine society clin- ical practice guideline 显示文摘 | Holick MF Binkley NC Bischoff Ferrari HA | 2011 | The Journal of Clinical Endocrinology and Metabolism2011，96，7： | 1 |
| 10 | Evaluation, treatment, and prevention of vitamin D deficiency : an Endocrine Soci- ety Clinical Practice Guideline 显示文摘 | Holick MF Binkley NC Bischoff - Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，12： | 1 |
| 11 | Evaluation, treat- ment,and prevention of vitamin D deficiency:an endocrine society clin- ical practice guideline 显示文摘 | Holick MF Binkley NC Bischoff - Ferrari HA | 2011 | J Clin Endocrin Metab2011，96，7： | 1 |
| 12 | Calcineurin signaling regulates human islet I~-cell survival显示文摘 | Soleimanpour S Crutchlow MF Ferrari AM | 2010 | J Biol Chem2010，285，40： | 1 |
| 13 | Calcineurin signaling regulates human islet {be- ta}-cell survival显示文摘 | Soleimanpour SA Crutchlow MF Ferrari AM | 2010 | J Biol Chem2010，285，40： | 1 |
| 14 | Evalua- tion, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline显示文摘 | Holiek MF Binkley NC Bischoff - Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，7： | 1 |
| 15 | Evaluation, treatment, and prevention of vitamin D deficiency : an Endocrine So- ciety clinical practice guideline 显示文摘 | Holick MF Binkley NC Bischoff- Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，7： | 1 |
| 16 | Multicaulisin, a new Diels-Alder type adduct from mulberry tree 显示文摘 | Ferrari F Delle MF | 2000 | Fitoterapia2000，71，2： | 1 |
| 17 | Evaluation, treatment, and preven- tion of vitamin D deficiency: An Endocrine Society clinical practice guideline 显示文摘 | Holic MF Binkley NC Bischoff- Ferrari | 2011 | J Clin Endocrinol Metab2011，96，7： | 1 |
| 18 | Change in the expression of NPY receptor subtypes Y1 and Y2 in central and peripheral neurons related to the control of blood pressure in control of blood pressure in rats following experimental hypertention显示文摘 | Ferrari MF Maximino JR | 2004 | Neuropeptides2004，38，： | 1 |
| 19 | Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline显示文摘 | Holick MF Binkley NC Bischoff -Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，12： | 1 |
| 20 | Evaluation,treatment,and prevention of vitamin D deficiency:an endocrine society clinical practice guideline显示文摘 | Holick MF Binkley NC Bischoff Ferrari HA | 2011 | J Clin Endocrinol Metab2011，96，7： | 1 |
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