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| 1 | Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices显示文摘AIM:To evaluate the efficacy and safety of undiluted N-butyl-2 cyanoacrylate plus methacryloxysulfolane(NBCM)as a prophylactic treatment for gastric varices(GV)bleeding.METHODS:This prospective study was conducted at a single tertiary-care teaching hospital between October 2009 and March 2013.Patients with portal hypertension(PH)and GV,with no active gastrointestinal bleeding,were enrolled in primary prophylactic treatment with NBCM injection without lipiodol dilution.Initial diagnosis of GV was based on endoscopy and confirmed with endosonography(EUS); the same procedure was used after treatment to confirm eradication of GV.After puncturing the GV with a regular injection needle,1 mL of undiluted NBCM was injected intranasally into GV.The injection was repeated as necessary to achieve eradication or until a maximum total volume of 3 mL of NBCM had been injected.Patients were followed clinically and evaluated with endoscopy at 3,6 and 12 mo.Later follow-ups were performed yearly.The main outcome measures were efficacy(GV eradication),safety(adverse events related to cyanoacrylate injection),recurrence,bleeding from GV and mortality related to GV treatment.RESULTS:A total of 20 patients(15 male)with PH and GV were enrolled in the study and treated with undiluted NBCM injection.Only 2(10%)patients had no esophageal varices(EV); 18(90%)patients were treated with endoscopic band ligation to eradicate EV before inclusion in the study.The patients were followed clinically and endoscopically for a median of 31 mo(range:6-40 mo).Eradication of GV was observed in all patients(13 patients were treated with 1 session and 7 patients with 2 sessions),with a maximum injected volume of 2 mL NBCM.One patient had GV recurrence,confirmed by EUS,at 6-mo follow-up,and another had late recurrence with GV bleeding after 35 mo of follow-up; overall,GV recurrence was observed in 2 patients(10%),after 6 and 35 mo of follow-up,and GV bleeding rate was 5%(1 patient).Mild epigastric pain was reported by 3 patients(15%).No mortality or major complications,including embolism,or damage to equipment were observed.CONCLUSION:Endoscopic injection with NBCM,without lipiodol,may be a safe and effective treatment for primary prophylaxis of gastric variceal bleeding. | Matheus Cavalcante Franco Gustavo Flores Gomes Frank Shigeo Nakao Gustavo Andrade de Paulo Angelo Paulo Ferrari Jr Ermelindo Della Libera Jr | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，6： | 16 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | 2011 update tothe Society of Thoracic Surgeons and the Society of CardiovascularAnesthesiologists blood conservation clinical practiceguidelines 显示文摘 | Ferraris VA Brown JR Despotis GJ | 2011 | Ann Thorac Surg2011，91，： | 1 |
| 4 | 2011 update to the society of thoracic sur- geons and the society of cardiovascular anesthesiologists blood conservation clini- cal practice guidelines 显示文摘 | Ferraris VA Brown JR Despotis GJ | 2011 | Ann Thorac Turg2011，91，3： | 1 |
| 5 | 2011 update to the Soci-ety of Thoracic Surgeons and the Society of Cardiovascular Anes-thesiologists blood conservation clinical practice guidelines显示文摘 | Society of Thoracic Surgeons Blood Conservation Guideline TaskForce Ferraris VA Brown JR | 2011 | Ann Thorac Surg2011，91，3： | 1 |
| 6 | Risk factors for complications after performance of ERCP显示文摘 | Vandervoort J Soetikno R M Tham T C Wong R C Ferrari A P Jr Montes H | 2002 | Gastrointest Endosc2002，56，： | 1 |
| 7 | 2011 update to the soci- ety of thoracic surgeons and the society of cardiovascular anesthesi- ologists blood conservation clinical practice guidelines显示文摘 | Ferraris VA Brown JR Despotis GJ | 2011 | Ann Tho- rac Surg2011，91，： | 1 |
| 8 | Substance abuse relapsein Oxford house recovery homes : A survival analysis evaluation显示文摘 | HARVEY R JASON LA FERRARI JR | 2016 | Subst Abuse2016，37，2： | 1 |
| 9 | Numerical simulation of vortex-induced vibration on flexible cylinders 显示文摘 | Yamamoto C T Meneghini J R Saltara F Fregonesi R A Ferrari J A Jr | 2004 | Journal of Fluids and Structures2004，19，： | 1 |
| 10 | Procrastination: different time o- rientations reflect different motives显示文摘 | Ferrari JR Diaz-Morales J F | 2007 | J Res Pets2007，41，3： | 1 |
| 11 | Reducing academic procrastination through a group treatment program:a pilot study 显示文摘 | Ozer BU Demir A Ferrari JR | 2013 | Journal of Ratio- hal-Emotive Cognitive-Behavior Therapy2013，31，3： | 1 |
| 12 | Change in the expression of NPY receptor subtypes Y1 and Y2 in central and peripheral neurons related to the control of blood pressure in rats following experimental hypertension 显示文摘 | Coelho EF Ferrari MF Maximino JR | 2004 | Neuropeptides2004，38，23： | 1 |
| 13 | Posterolateral instability of the knee: diagnosis and treatment of acute and chronic instability 显示文摘 | Ferrari JD Bach BR Jr | 1999 | Sports Med Arthrosc Rev1999，7，： | 1 |
| 14 | Prevalence of procrastination among samples of adults显示文摘 | HARRIOTT J FERRARI JR | 1996 | Psychol Rep1996，78，2： | 1 |
| 15 | 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesi- ologists blood conservation clinical practice guidelines 显示文摘 | Society of Thoracic Surgeons Blood Conservation Guideline Task Force Ferraris VA Brown JR | 2011 | Ann Thorac Surg2011，91，3： | 1 |
| 16 | Procrastinationand attention: Factoranalysis of attention deficit, boredomness, intelligence, self - esteetn, and yask delay frequencies显示文摘 | Ferrari JR | 2000 | Journal of Social Behavior and Personality2000，15，： | 1 |
| 17 | Compulsive Procrastinatim: Some Self- reported personality characteristics 显示文摘 | Ferrari JR | 1997 | Psychological Reports1997，，68： | 1 |
| 18 | Exploring procrastina- tion in corporate settings: sex, status, and settings for a- rousal and avoidance Types 显示文摘 | Ferrari JR Doroszko E Joseph N | 2005 | Individual Differences Research2005，3，2： | 1 |
| 19 | Perceptions of parental control and the development of indecision among late adolescent females显示文摘 | Ferrari JR Olivette MJ | 1993 | Adolesc1993，28，： | 1 |
| 20 | Risk factors for complications after performance of ERCP显示文摘 | Vandervoort J Soetikno R M Tham T C Wong R C Ferrari A P Jr Montes H | 2002 | Gastrointest Endosc2002，56，： | 1 |
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