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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Combined treatment with a β-blocker and intermittent PTH improves bone mass and mieroarehitecture in ovariectomized mice 显示文摘 | Pierroz D D Bouxsein M L Rizzoli R Ferrari S L | 2006 | Bone2006，39，： | 1 |
| 3 | A capacitive sen- sor system for the analysis of two-phase flows of oil and conductive water 显示文摘 | Demori M Ferrari V Strazza D | 2010 | Sensors and Actuators A: Physical2010，163，1： | 1 |
| 4 | Caspase-dependent alterations of Ca2+signaling in the induction of apoptosis by hepatitis B virus X protein显示文摘 | Chami M Ferrari D Nicotera P | 2003 | The Journal of Biological Chemistry2003，278，31： | 1 |
| 5 | Ethanol production from eucalyptus wood hemicellulose hydrolysate by Pichia stipitis显示文摘 | Ferrari M D Neirotti E Albornoz C | 1992 | Biotechnology and Biocngineering1992，40，7： | 1 |
| 6 | Muscle regeneration by bone marrow- derived myogenic progenitors显示文摘 | Ferrari G Angelis D Coletta M | 1998 | Science1998，279，5356： | 1 |
| 7 | CDOM absorption characteristics with relation to fluorescence and salinity in coastal areas of the Southern Baltic Sea 显示文摘 | Ferrari G M Dowell M D | 1998 | Estuar Coast Shelf S1998，47，1： | 1 |
| 8 | Kinetic mechanism and mierostruerure during the formation of Si3N4 matrix in Si3N4 MoSi2 composites显示文摘 | Beruto D T Ferrari A Giordani M Marino F | 2003 | Materials Science and Engineering2003，，355： | 1 |
| 9 | Robust generation ofoligodendrocyte progenitors from human neural stem cellsand engraftment in experimental demyelination models inmice显示文摘 | Neri M Maderna C Ferrari D | 2010 | PLoS One2010，5，10： | 1 |
| 10 | New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation显示文摘 | Songia S Gnocchi P Ferrari M Fornasiero C D'Alessio R | 1999 | J Immunol1999，162，12： | 1 |
| 11 | Arabidopsis polygalacturonase-inhibiting proteins ( PGIP ) areregulated by diVerent signal transduction pathways during fungalinfection 显示文摘 | Ferrari S Vairo D Ausubel F M Cervone F De Lorenzo G | 2003 | Plant Cell2003，15，： | 1 |
| 12 | Template-impinted nanostructured swfaces for protein recognition 显示文摘 | Shi H Q Tsai W B Garrison M D Ferrari S Ratner B D | 1999 | Nature1999，398，6728： | 1 |
| 13 | Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors 显示文摘 | Idzko M Dichmann S Ferrari D | 2002 | Blood2002，100，： | 1 |
| 14 | Polygalaeturonase-inhihiting protein 2 of Phaseolus vulgaris inhibits BcPG1, a polygalacturonase of Botrytis cinerea important for pathogenicity, and protects transgenic plants from infection 显示文摘 | Manfredini C Sicilia F Ferrari S Pontiggia D Salvi G Caprai C Lorito M De Lorenzo G | 2006 | Physiol Mol Plant Pathol2006，67，： | 1 |
| 15 | Relationship between the optical properties of ehromophoric dissolved organic mat- ter and total concentration of dissolved organic carbon in the southern Baltic Sea region显示文摘 | FERRARI G M DOWELL M D GROSSI S | 1996 | Marine Chemistry1996，55，34： | 1 |
| 16 | Laparoscopy- assisted abdominal aortic aneurysm repair: early and middle-term results of a consecutive series of 122 cases 显示文摘 | Ferrari M Adami D Del Corso A | 2006 | J Vase Surg2006，43，4： | 1 |
| 17 | Optical spectroscopy of zinc borate glass activated by Pr^3+ ions 显示文摘 | LONGO L D FERRARI M ZANGHELLINI E | 1998 | Journal Non-Caystalline Solids1998，231，： | 1 |
| 18 | Surface silver-doping of biocompatible glasses to induce antibacterial properties 显示文摘 | Miola M Ferraris S Nunzio S D | 2009 | Journal of Materials Science-Materials in Medicine2009，20，： | 1 |
| 19 | CD OM absorption characteristics with relation to fluorescence and salinity in coastal areas of the southern Baltic Sea显示文摘 | Ferrari G M Dowell M D | 1998 | Estuar Coast Shelf Sci1998，47，1： | 1 |
| 20 | Threedimensional quantitative structure-activity relationship analysis of a set of plasmodium falciparmn dihydrofolate reductase inhibitors using a pharmacophore generation approach 显示文摘 | Parenti M D Paeehioni S Ferrari A M | 2004 | J Med Chem2004，47，： | 1 |
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