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| 1 | A Comprehensive Survey on Fault Diagnosis and Fault Tolerance of DC-DC Converters显示文摘DC-DC converters are becoming more commonly used in power conversion solutions for energy management purposes,being employed in an ever-increasing range of DC-based applications,such as LED lighting,electric vehicles,energy storage solutions,and consumer electronics(laptops,smartphones,etc.).In this context,efficiency and reliability are critical.The research efforts made in improving reliability of DC-DC converters are still quite narrow and scattered.Moreover,DC-DC converters take the shape of an endless number of topologies,with different functionalities and operation principles,thus complicating the task of improving reliability of all forms of DC-DC converters.Consequently,compiling the information about the main failure modes,corresponding fault diagnostic algorithms and fault tolerance strategies developed so far,in a single document,becomes increasingly necessary.Accordingly,this paper presents an up-to-date review of the recent achievements attained regarding the improvement of availability and reliability of DC-DC converters. | Fernando Bento Antonio J.Marques Cardoso | 2018 | Chinese Journal of Electrical Engineering2018，4，3： | 2 |
| 2 | Serum pepsinogen test for early detection of gastric cancer in a European Country显示文摘 | Rafael Lomba-Viana Mário Dinis-Ribeiro Fernando Fonseca Anabela Silva Vieira Maria José Bento Bento Helena Lomba-Viana | 2012 | European Journal of Gastroenterology & Hepatology2012，，1： | 1 |
| 3 | Usefulness of serum C-reactive protein and calprotectin for the early detection of colorectal anastomotic leakage:A prospective observational study显示文摘BACKGROUND Colorectal anastomotic leakage(CAL)is one of the most dreaded complications after colorectal surgery,with an incidence that can be as high as 27%.This event is associated with increased morbidity and mortality;therefore,its early diagnosis is crucial to reduce clinical consequences and costs.Some biomarkers have been suggested as laboratory tools for the diagnosis of CAL.AIM To assess the usefulness of plasma C-reactive protein(CRP)and calprotectin(CLP)as early predictors of CAL.METHODS A prospective monocentric observational study was conducted including patients who underwent colorectal resection with anastomosis,from March 2017 to August 2019.Patients were divided into three groups:G1–no complications;G2–complications not related to CAL;and G3–CAL.Five biomarkers were measured and analyzed in the first 5 postoperative days(PODs),namely white blood cell(WBC)count,eosinophil cell count(ECC),CRP,CLP,and procalcitonin(PCT).Clinical criteria,such as abdominal pain and clinical condition,were also assessed.The correlation between biomarkers and CAL was evaluated.Receiver operating characteristic(ROC)curve analysis was used to compare the accuracy of these biomarkers as predictors of CAL,and the area under the ROC curve(AUROC),specificity,sensitivity,positive predictive value,and negative predictive value(NPV)during this period were estimated.RESULTS In total,25 of 396 patients developed CAL(6.3%),and the mean time for this diagnosis was 9.0±6.8 d.Some operative characteristics,such as surgical approach,blood loss,intraoperative complications,and duration of the procedure,were notably related to the development of CAL.The length of hospital stay was markedly higher in the group that developed CAL compared with the group with complications other than CAL and the group with no complications(median of 21 d vs 13 d and 7 d respectively;P<0.001).For abdominal pain,the best predictive performance was on POD4 and POD5,with the largest AUROC of 0.84 on POD4.Worsening of the clinical condition was associated with the diagnosis of CAL,presenting a higher predictive effect on POD5,with an AUROC of 0.9.WBC and ECC showed better predictive effects on POD5(AUROC=0.62 and 0.7,respectively).Those markers also presented a high NPV(94%-98%).PCT had the best predictive effect on POD5(AUROC=0.61),although it presented low accuracy.However,this biomarker revealed a high NPV on POD3,POD4,and POD5(96%,95%,and 96%,respectively).The mean CRP value on POD5 was significantly higher in the group that developed CAL compared with the group without complications(195.5±139.9 mg/L vs 59.5±43.4 mg/L;P<0.00001).On POD5,CRP had a NPV of 98%.The mean CLP value on POD3 was significantly higher in G3 compared with G1(5.26±3.58μg/mL vs 11.52±6.81μg/mL;P<0.00005).On POD3,the combination of CLP and CRP values showed a high diagnostic accuracy(AUROC=0.82),providing a 5.2 d reduction in the time to CAL diagnosis.CONCLUSION CRP and CLP are moderate predictors of CAL.However,the combination of these biomarkers presents an increased diagnostic accuracy,potentially decreasing the time to CAL diagnosis. | Nuno J G Rama Marlene C C Lages Maria Pedro S Guarino Óscar Lourenço Patrícia C Motta Lima Diana Parente Cândida S G Silva Ricardo Castro Ana Bento Anabela Rocha Fernando Castro-Pocas João Pimente | 2022 | World Journal of Gastroenterology2022，28，24： | 1 |
| 4 | Clinicopathological significance of ERCC1 expression in breast cancer显示文摘 | Renê Gerhard Ana Carvalho Vítor Carneiro Rui San Bento Gilberto Uemura Madalena Gomes André Albergaria Fernando Schmitt | 2013 | Pathology - Research and Practice2013，，： | 1 |
| 5 | Comprehensive Survey and Critical Evaluation of the Performance of State-of-the-art LED Drivers for Lighting Systems显示文摘The adoption of light-emitting diodes(LEDs)for lighting applications is becoming increasingly relevant as this recent technology is advancing.Given the recent uptake of LED lighting technologies for distinctive end-uses,the research community has also committed to the development of an ever-increasing range of power electronic converters that are suitable for yielding maximum quality lighting,high efficiency,and long lifetimes.As one of the most recent and promising technologies of the moment,it is vital to fully understand the performance and merits of each state-of-the-art LED lighting technology.Accordingly,this paper compiles essential information about a broad range of state-of-the-art LED lighting systems,aiming to compare their performances in terms of efficiency.Based on the comparative analysis,the main merits and drawbacks of each LED lighting system architecture are obtained.Then,a detailed evaluation of the performance of a particular LED lighting system and the corresponding control strategy is developed,thereby enabling a clear view of the evolution of the performance of the system as a function of parameters like supply voltage and number of driver channels. | Fernando Bento Antonio J.Marques Cardoso | 2021 | Chinese Journal of Electrical Engineering2021，7，2： | 0 |
| 6 | Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate显示文摘Background: The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with resistance to gastrointestinal parasites, particularly Haemonchus contortus, in a breed of sheep adapted to tropical climate. Phenotypes evaluations were performed to verify resistance to gastrointestinal parasites, and were divided into two categories: i) farm phenotypes, assessing body condition score(BCS), degree of anemia assessed by the famacha chart(FAM), fur score(FS) and feces consistency(FC); and ii) lab phenotypes,comprising blood analyses for hematocrit(HCT), white blood cell count(WBC), red blood cell count(RBC),hemoglobin(HGB), platelets(PLT) and transformed(log10) egg per gram of feces(EPG_(log)). A total of 576 animals were genotyped with the Ovine SNP12k Bead Chip(Illumina, Inc.), that contains 12,785 bialleleic SNP markers. The variance components were estimated using a single trait model by single step genomic BLUP procedure.Results: The overall linkage disequilibrium(LD) mean between pairs of markers measured by r2 was 0.23. The overall LD mean between markers considering windows up to 10 Mb was 0.07. The mean LD between adjacent SNPs across autosomes ranged from 0.02 to 0.10. Heritability estimates were low for EPG_(log)(0.11), moderate for RBC(0.18), PLT(0.17) HCT(0.20), HGB(0.16) and WBC(0.22), and high for FAM(0.35). A total of 22, 21, 23, 20, 26, 25 and 23 windows for EPG_(log)for FAM, WBC, RBC, PLT, HCT and HGB traits were identified, respectively. Among the associated windows, 10 were shown to be common to HCT and HGB traits on OAR1, OAR2, OAR3, OAR5, OAR8 and OAR15.Conclusion: The traits indicating gastrointestinal parasites resistance presented an adequate genetic variability to respond to selection in Santa Inês breed, and it is expected a higher genetic gain for FAM trait when compared to the others. The level of LD estimated for markers separated by less than 1 Mb indicated that the Ovine SNP12k Bead Chip might be a suitable tool for identifying genomic regions associated with traits related to gastrointestinal parasite resistance. Several candidate genes related to immune system development and activation, inflammatory response,regulation of lymphocytes and leukocytes proliferation were found. These genes may help in the selection of animals with higher resistance to parasites. | Mariana Piatto Berton Rafael Medeiros de Oliveira Silva Elisa Peripolli Nedenia Bonvino Stafuzza Jesús Fernández Martin Maria Saura álvarez Beatriz Villanueva Gavina Miguel Angel Toro Georgget Banchero Priscila Silva Oliveira Joanir Pereira Eler Fernando Baldi José Bento Sterman Ferraz | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 0 |
| 7 | Development of a warning score for early detection of colorectal anastomotic leakage:Hype or hope?显示文摘BACKGROUND Colorectal anastomotic leakage(CAL),a severe postoperative complication,is associated with high morbidity,hospital readmission,and overall healthcare costs.Early detection of CAL remains a challenge in clinical practice.However,some decision models have been developed to increase the diagnostic accuracy of this event.AIM To develop a score based on easily accessible variables to detect CAL early.METHODS Based on the least absolute shrinkage and selection operator method,a predictive classification system was developed[Early ColoRectAL Leakage(E-CRALL)score]from a prospective observational,single center cohort,carried out in a colorectal division from a non-academic hospital.The score performance and CAL threshold from postoperative day(POD)3 to POD5 were estimated.Based on a precise analytical decision model,the standard clinical practice was compared with the E-CRALL adoption on POD3,POD4,or POD5.A cost-minimization analysis was conducted,on the assumption that all alternatives delivered similar health-related effects.RESULTS In this study,396 patients who underwent colorectal resection surgery with anastomosis,and 6.3%(n=25)developed CAL.Most of the patients who developed CAL(n=23;92%)were diagnosed during the first hospital admission,with a median time of diagnosis of 9.0±6.8 d.From POD3 to POD5,the area under the receiver operating characteristic curve of the E-CRALL score was 0.82,0.84,and 0.95,respectively.On POD5,if a threshold of 8.29 was chosen,87.4%of anastomotic failures were identified with E-CRALL adoption.Additionally,score usage could anticipate CAL diagnosis in an average of 5.2 d and 4.1 d,if used on POD3 and POD5,respectively.Regardless of score adoption,episode comprehensive costs were markedly greater(up to four times)in patients who developed CAL in comparison with patients who did not develop CAL.Nonetheless,the use of the E-CRALL warning score was associated with cost savings of€421442.20,with most(92.9%)of the savings from patients who did not develop CAL.CONCLUSION The E-CRALL score is an accessible tool to predict CAL at an early timepoint.Additionally,ECRALL can reduce overall healthcare costs,mainly in the reduction of hospital costs,independent of whether a patient developed CAL. | Nuno J G Rama Óscar Lourenço Patrícia C Motta Lima Maria Pedro S Guarino Diana Parente Ricardo Castro Ana Bento Anabela Rocha Fernando Castro-Poças João Pimentel | 2022 | World Journal of Gastrointestinal Surgery2022，14，11： | 0 |
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