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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Sedation for e- lectroencephalography with dexmedetomidine or chloral hy- drate: a comparative study on the qualitative and quantitative e- lectroencephalogram pattern 显示文摘 | Fernandes ML Oliveira WM Santos MD | 2015 | J Neurosurg Anesthesiol2015，27，1： | 1 |
| 3 | Quantifieation of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using Fourier-domain optical coherence tomography 显示文摘 | Monteiro ML Fernandes DB Apostolos-Pereira SL | 2012 | Invest Ophthalmol Vis Sci2012，53，7： | 1 |
| 4 | Immunoexpression of hMSH2 and hMLH1 in oral squamous cell carcinoma and its relationship to histological grades of malignancy 显示文摘 | Fernandes AM Ramos-Jorge ML Cardoso SV | 2008 | J Oral Pathol Med2008，37，9： | 1 |
| 5 | Sexual differences in reproductive phenology and their consequences for the demography of Baccharis dracunculifolia (Asteraceae), a dioecious tropical shrub 显示文摘 | Espírito-Santo MM Madeira BG Neves FS Faria ML Fagundes M Fernandes GW | 2003 | Ann Bot2003，91，： | 1 |
| 6 | Effeets of age on elements of insulin signaling pathway in central nervous system of rats显示文摘 | Fernandes ML Saad MJ Velloso LA | 2001 | Endocrine2001，16，3： | 1 |
| 7 | Effects of age on elements of insulin-signaling pathway in cerebral nervous system of rats显示文摘 | Fernandes ML Saad MJ Velloso LA | | 0，，3： | 1 |
| 8 | Comparing language lateralization determined by dichotic listening and fMRI activa tion in frontal and temporal lobes in children with epilepsy显示文摘 | Fernandes MA Smith ML Logan W | 2006 | Brain Lang2006，96，： | 1 |
| 9 | Effects of an intravitreal daunomycin implant on experimental proliferative vitreoretinopathy:simultaneous pharmacokinetics and pharmacodynamic evalution显示文摘 | Rahimy MH Peyman GA Fernandes ML el-Sayed SH Luo Q Borhani H | 1994 | J Ocul Pharmacol1994，10，6： | 1 |
| 10 | Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures显示文摘 | Rodrigues MC Rossetti F Foresti ML Arisi GM Furtado MA Dal-Có1 ML Bertti P Fernandes A Santos FL Del Vecchio F Garcia-Cairasco N | | 0，，03： | 1 |
| 11 | Anorectal manometry in children with chronic functional constipation显示文摘 | Bigelli RH Fernandes Ml Vicente YA | 2005 | Arq Gastroenterol2005，42，3： | 1 |
| 12 | Refractory pemphigus vulgaris associated with herpes infection:case report and review显示文摘 | Brandao ML Fernandes NC Batista DP | 2011 | Rev Inst Med Trop Sao Paulo2011，53，2： | 1 |
| 13 | Interleukin 6:a possible marker of disease activity in adult onset Still disease 显示文摘 | Scheinberg MA Chapira E Fernandes ML | 1996 | Clin Exp Rheumatol1996，14，6： | 1 |
| 14 | Effects of age on elements of insulinsignaling pathway in central nervous system of rats显示文摘 | Fernandes ML Saad MJ Velloso LA | 2001 | Endocrine2001，16，： | 1 |
| 15 | Quantification of retinal neural loss in patients with neuromyeli-tis optica and multiple sclerosis with or without optic neuritis u-sing Fourier- domain optical coherence tomography 显示文摘 | Monteiro ML Fernandes DB Apostolos-Pereira SL CaUegaro D | 2012 | InvestOphthalmol Vis2012，53，7： | 1 |
| 16 | Comparing language lateralization determined by dichotic listening and fMRI activation in frontal and temporal lobes in children with epilepsy显示文摘 | Fernandes MA Smith ML Logan W | 2006 | Brain Lang2006，96，1： | 1 |
| 17 | Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blindstudy显示文摘 | Fernandes ML Pires KC Tiburcio MA | 2012 | J Anesth2012，26，2： | 1 |
| 18 | An immunomagnetic separation-PCR method for detection of pathogenie Leptospira in biological fluids显示文摘 | Fernandes CP Seixas FK Coutinho ML | 2008 | Hybridoma2008，27，5： | 1 |
| 19 | Non functioning pi tuitary adenomas : clinical feature, lahoratorial and imaging assess ment,therapeutic management and outcome显示文摘 | Cury ML Fernandes JC Machado HR | 2009 | Arq Bras Endocrinol Metabol2009，53，1： | 1 |
| 20 | Delay in treatment of ear-ly-stage hepatocellular carcinoma using radiofrequency ablationmay impact survival of cirrhotic patients in a surveillance program显示文摘 | Chen WT Fernandes ML Lin CC | 2011 | Surg Oncol2011，103，： | 1 |
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