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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Osteoporosis and inflammation显示文摘 | Lacativa PG Farias ML | | 0，，02： | 1 |
| 3 | I-Iypercalcemia of malignancy: clinical features, diag- nosis and treatment显示文摘 | Farias ML | 2005 | Arq Bras Endocrinol Metabol2005，49，5： | 1 |
| 4 | A proteome reference map for Vibrio cholerae El Tor 显示文摘 | Coelho A de Oliveira Santos E Faria ML | 2004 | Proteomics2004，4，5： | 1 |
| 5 | The versatility of the free lateral arm flap in head and neck soft tissue reconstruction:clinical experience of 210 cases显示文摘 | Marques Faria JC Rodrigues ML Scopel GP | 2008 | Plast Reconstr Aesthet Surg2008，61，2： | 1 |
| 6 | Fetal exomphalos at 11 to 14 weeks of gestation 显示文摘 | Snijders RJ Brizot ML Faria M | 1995 | Ultrasonnd Med1995，14，8： | 1 |
| 7 | Sexual differences in reproductive phenology and their consequences for the demography of Baccharis dracunculifolia (Asteraceae), a dioecious tropical shrub 显示文摘 | Espírito-Santo MM Madeira BG Neves FS Faria ML Fagundes M Fernandes GW | 2003 | Ann Bot2003，91，： | 1 |
| 8 | Hypercalcemia of malignancy:clinical features, diagnosis and treatment 显示文摘 | Farias ML | 2005 | Arq Bras Endocrinol Metabol2005，49，5： | 1 |
| 9 | Pain and hope in patients with cancer: a role for cognition显示文摘 | Barbour ML Faria TN Stannard B | 2003 | Caneer Nurse2003，26，1： | 1 |
| 10 | Maternal-fetal distribution of calcium, iron, copper, and zinc in pregnant teenagers and adults显示文摘 | Moraes ML Faria Barbosa R Santo RE | 2011 | Biological Trace Element Research2011，139，2： | 1 |
| 11 | Distribution of calcium,iron,copper,and zinc in two portionsof placenta of teenager and adult women显示文摘 | de Moraes ML de Faria Barbosa R Santo RE | 2011 | Biol Trace ElemRes2011，143，3： | 1 |
| 12 | Pain and hope in patients with cancer a role for cognition显示文摘 | Barbour ML Faria TN Stannard B | 2003 | Cancer Nurse2003，26，1： | 1 |
| 13 | Osteoporosis and inflammation 显示文摘 | Lacativa PG Farias ML | 2010 | Arq Bras Endocrinol Metabol2010，54，： | 1 |
| 14 | Antifungal activity of propolis extract against yeasts isolated from vaginal exudates 显示文摘 | Dalben Dora KF Faria MG Bruschi ML | 2010 | J AlternComplement Med2010，16，3： | 1 |
| 15 | Osteoporosis and inflammation显示文摘 | Lacativa PG Farias ML | 2010 | Arq Bras Endocrinol Metabol2010，54，2： | 1 |
| 16 | Osteoporosis and inflammation 显示文摘 | Lacativa PG Farias ML | 2010 | Arq Bras Endocrinol Metabol2010，54，2： | 1 |
| 17 | Fetal exomphalos at 11-14 weeks of gestation 显示文摘 | Snijders RJ Brizot ML Faria M et al | 1995 | J UltrasoundMed1995，14，8： | 1 |
| 18 | Pain and hope in patients with cancer: A Role for cognition 显示文摘 | Barbour ML Faria TN Stannard B | 2003 | Cancer Nurse2003，26，1： | 1 |
| 19 | Recombinant human bone morphogenetic protein-2 in absorbable col agen sponge enhances bone healing of tibial osteotomies in dogs显示文摘 | Faria ML Lu Y Heaney K | | 0，，02： | 1 |
| 20 | Osteopomsis and inflammation 显示文摘 | Lacativa PG Farias ML | 2010 | Arg Bras Endocrinol Metabol2010，54，2： | 1 |
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