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| 1 | Rice RING protein OsBBI1 with E3 ligase activity confers broad-spectrum resistance against Magnaporthe oryzae by modifying the cell wall defence显示文摘新兴的证据建议 E3 ligases 在多样的生物过程起关键作用,包括在植物的天生的有免疫力的回答。然而,在植物的 E3 ligase 参与的机制天生的免疫是不清楚的。我们报导那米饭基因, OsBBI1,与 E3 ligase 活动编码戒指手指蛋白质,调停用途广泛的疾病抵抗。OsBBI1 的表示被米饭强风真菌 Magnaporthe oryzae,以及化学 inducers 导致, benzothiadiazole 和水杨酸酸。生物化学的分析表明那 OsBBI1 蛋白质在 vitro 拥有 E3 ubiquitin ligase 活动。基因分析表明在一根 Tos17 插入线的 OsBBI1 功能的损失增加了危险性,当在转基因的植物的 OsBBI1 的 overexpression 授与提高的抵抗到 M 的多重赛跑时。oryzae。这显示 OsBBI1 对强风真菌调制用途广泛的抵抗。OsBBI1-overexpressing 植物由 M 在感染地点在房间墙中在酉分的混合物的房间和蛋白质的 cross-linking 显示出 H2O2 累积的高水平。oryzae 与相比野类型(WT ) 植物。房间墙在 OsBBI1-overexpressing 植物是更厚的并且在变异的植物更薄比在 WT 植物。我们的结果建议 OsBBI1 由修改房间墙防卫回答调制用途广泛的抵抗到强风真菌。OsBBI1 的功能的描述为在米饭对最破坏的疾病构造用途广泛的抵抗提供卓见进 E3 调停 ligase 的天生的免疫,和一个实际工具。 | Wei Li Sihui Zhong Guojun Li Qun Li Bizeng Mao Yiwen Deng Huijuan Zhang Longjun Zeng Fengming Song Zuhua He | 2011 | Cell Research2011，21，5： | 30 |
| 2 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 3 | The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication显示文摘Coix is a grass crop domesticated as early as the Neolithic era.It is still widely cultivated for both highly nutritional food and medicinal use.However,the genetic study and breeding of this crop are hindered by the lack of a sequenced genome.Here,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding genes.Comparative genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in sorghum.We further constructed a genetic map and mapped several important traits,especially the strength of hull.Selection of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix domestication.The papery hull makes seed easier to process and germinate.Anatomic and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall biogenesis.We also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,respectively.The two QTLs were further fine mapped within intervals of 250 kb and 146 kb,respectively.These resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop. | Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo YawenYang-Hailan Liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou | 2020 | Molecular Plant2020，13，2： | 11 |
| 4 | Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure显示文摘Asthenozoospermia is the most common cause of male infertility.Dynein protein arms play a crucial role in the motility of both the cilia and flagella,and defects in these proteins generally impair the axoneme structure and cause primary ciliary dyskinesia.But relatively little is known about the influence of dynein protein arm defects on sperm flagella function.Here,we recruited 85 infertile patients with idiopathic asthenozoospermia and identified bi-allelic mutations in DNAH7(NM_018897.3)from three patients using whole-exome sequencing.These variants are rare,highly pathogenic,and very conserved.The spermatozoa from the patients with DNAH7 bi-allelic mutations showed specific losses in the inner dynein arms.The expression of DNAH7 in the spermatozoa from the DNAH7-defective patients was significantly decreased,but these patients were able to have their children via intra-cytoplasmic sperm injection treatment.Our study is the first to demonstrate that bi-allelic mutations in DNAH7 may impair the integrality of axoneme structure,affect sperm motility,and cause asthenozoospermia in humans.These findings may extend the spectrum of etiological genes and provide new clues for the diagnosis and treatment of patients with asthenozoospermia. | Xiaoli Wei Yanwei Sha Zijie Wei Xingshen Zhu Fengming He Xiaoya Zhang Wensheng Liu Yifeng Wang Zhongxian Lu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 2 |
| 5 | A novel local- ization algorithm based on isomap and partial least squares for wireless sensor networks 显示文摘 | LI Bing HE Yigang GUO Fengming | 2013 | Instrumentation and Measurement2013，62，2： | 1 |
| 6 | Carbonization fabrication of a piezoresistive sensor with improved sensitivity via Ni decoration of carbonized cotton fibers显示文摘The development of wearable electronics urgently requires the cost-effective and scalable fabrication of high-performance pressure sensors.This work aims to develop a simple carbonization strategy to facilitate sensor sensitivity by decorating discrete nickel nanoparticles on carbonized cotton fibers(CCFs).The increased air gap between the fibers at the unloading state,as well as the enlargement of the deformation distance and the contact area between the conductive materials at the loading state,contribute to a more significant resistance change.Therefore,the sensitivity of the piezoresistive sensor is improved more than 5 times within 1 N by introducing Ni nanoparticles,and it is characterized by a rapid response(~160 ms)and recovery(~100 ms),wide detection range(~20 N/~130 kPa),and good durability(~4000 cycles).The flexible sensor has been successfully demonstrated to monitor human movements,physical stimuli,and pressure distribution.Furthermore,the proposed device can control temperature accurately as a uniform and large-scale heater.This work reveals that the Ni@CCFs-based sensor is prospective in wearable electronics,artificial intelligence,health monitoring,medical diagnosis and treatment. | HE Xiang WANG FengMing LIANG YiYing WU JiaWei LIANG JiongHong SHEN GengZhe LI BaiJun SU DaoJian ZHANG Chi SONG WeiDong HE Xin | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 7 | Study on Forecast Scenarios for Simulation of Future Urban Growth in Shenyang City Based on SLEUTH Model显示文摘The SLEUTH urban growth model was used to simulate future urban growth patterns and to explore potential environ-mental impacts of urban development under different conditions of development in Shenyang City, China. The SLEUTH model was calibrated with historical data (1988-2004) extracted from a time series of TM satellite images, and the future growth was pro-jected out to 2030 assuming three different policy scenarios: (1) current trends scenario (Scenario CT), (2) regional policy and ur-ban planning scenario (Scenario PP), and (3) environmental protection scenario (Scenario EP). Scenario analysis showed that urban growth would accelerate under all policy scenarios with significant differences in development pattern and sustainability after 2016. Urban development under Scenario CT would lead to substantial loss of resource lands than that under the other two scenarios, and the urban landscape pattern would be increasingly complex and dispersed. In contrast, urban growth under scenario PP and EP would consume less natural resource land and show a relatively compact urban development pattern during the prediction period. This study suggested that it is crucial to take stringent urban planning and management measures to control future urban growth and to protect primary farmland and the support system of urban ecology in Shenyang City. The SLEUTH model is a useful planning tool to guide sustainable utilization of urban land resources to a certain extent. | WU Xiaoqing HU Yuanman HE Hongshi XI Fengming BU Rencang | 2010 | Geo-Spatial Information Science2010，13，1： | 0 |
| 8 | An improved algorithm for retrieving thin sea ice thickness in the Arctic Ocean from SMOS and SMAP L-band radiometer data显示文摘The aim of this study was to develop an improved thin sea ice thickness(SIT)retrieval algorithm in the Arctic Ocean from the Soil Moisture Ocean Salinity and Soil Moisture Active Passive L-band radiometer data.This SIT retrieval algorithm was trained using the simulated SIT from the cumulative freezing degree days model during the freeze-up period over five carefully selected regions in the Beaufort,Chukchi,East Siberian,Laptev and Kara seas and utilized the microwave polarization ratio(PR)at incidence angle of 40°.The improvements of the proposed retrieval algorithm include the correction for the sea ice concentration impact,reliable reference SIT data over different representative regions of the Arctic Ocean and the utilization of microwave polarization ratio that is independent of ice temperature.The relationship between the SIT and PR was found to be almost stable across the five selected regions.The SIT retrievals were then compared to other two existing algorithms(i.e.,UH_SIT from the University of Hamburg and UB_SIT from the University of Bremen)and validated against independent SIT data obtained from moored upward looking sonars(ULS)and airborne electromagnetic(EM)induction sensors.The results suggest that the proposed algorithm could achieve comparable accuracies to UH_SIT and UB_SIT with root mean square error(RMSE)being about 0.20 m when validating using ULS SIT data and outperformed the UH_SIT and UB_SIT with RMSE being about 0.21 m when validatng using EM SIT data.The proposed algorithm can be used for thin sea ice thickness(<1.0 m)estimation in the Arctic Ocean and requires less auxiliary data in the SIT retrieval procedure which makes its implementation more practical. | Lian He Senwen Huang Fengming Hui Xiao Cheng | 2024 | Acta Oceanologica Sinica2024，43，3： | 0 |
| 9 | Author correction to‘Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA'[Acta Pharmaceutica Sinica B 13(2023)2585-2600]显示文摘The authors regret that one author was missed in the author list when preparing the manuscript,while the foundation to him was mentioned in the section of Acknowledgments.Dr.Qinjie Weng should be added to the author list because of his contribution in animal study and his foundation help us to complete this study.The authors sincerely apologize for any inconvenience caused to the journal and readers. | Wenxin Zhang Xiaohui Pan Yanjun Xu Hongjie Guo Mingming Zheng Xi Chen Honghai Wu Fengming Luan Qiaojun He Ling Ding Bo Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 10 | Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA显示文摘Mevalonate metabolism plays an important role in regulating tumor growth and progression;however,its role in immune evasion and immune checkpoint modulation remains unclear.Here,we found that non-small cell lung cancer(NSCLC)patients with higher plasma mevalonate response better to antiPD-(L)1 therapy,as indicated by prolonged progression-free survival and overall survival.Plasma mevalonate levels were positively correlated with programmed death ligand-1(PD-L1)expression in tumor tissues.In NSCLC cell lines and patient-derived cells,supplementation of mevalonate significantly upregulated the expression of PD-L1,whereas deprivation of mevalonate reduced PD-L1 expression.Mevalonate increased CD274 mRNA level but did not affect CD274 transcription.Further,we confirmed that mevalonate improved CD274 mRNA stability.Mevalonate promoted the affinity of the AU-rich elementbinding protein HuR to the 3'-UTR regions of CD274 mRNA and thereby stabilized CD274 mRNA.By in vivo study,we further confirmed that mevalonate addition enhanced the anti-tumor effect of anti-PD-L1,increased the infiltration of CD8^(+)T cells,and improved cytotoxic function of T cells.Collectively,our findings discovered plasma mevalonate levels positively correlated with the therapeutic efficacy of anti-PD-(L)1 antibody,and provided the evidence that mevalonate supplementation could be an immunosensitizer in NSCLC. | Wenxin Zhang Xiaohui Pan Yanjun Xu Hongjie Guo Mingming Zheng Xi Chen Honghai Wu Fengming Luan Qiaojun He Ling Ding Bo Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 11 | Liposome cocktail activator modulates hepatocytes and remodels the microenvironment to mitigate acute liver failure显示文摘Acute liver failure(ALF)is a mortal and critical hepatic disease,in which oxidative stress,inflammation storm and hepatocyte death are crucial in the pathogenesis.Hence,in contrast to the control of a single link,a combination therapy targeting multiple pathogenic links of the disease will be a favorable means to control the progression of the disease.In this study,we constructed dimethyl itaconate-loaded liposomes modified with dodecyl gallate as a cocktail activator to investigate its functional role in acetaminophen(APAP)-induced ALF.Our results demonstrated that the cocktail activator acted on hepatocytes and triggered cocktail efficacy,thereby simultaneously attenuating APAP-induced hepatocyte damage and remodeling the damage microenvironment.The cocktail activator could effectively scavenge reactive oxygen species,inhibit excessive inflammatory responses and reduce cell death in impaired hepatocytes for detoxification.More importantly,the cocktail activator could remodel the damage microenvironment,thus further promoting hepatocyte expansion and specifically switching macrophages from the M1 to M2 phenotype for a favorable liver regeneration of ALF.Furthermore,in APAP-induced ALF mouse model,the cocktail activator improved liver function,alleviated histopathological damage and increased survival rate.In summary,these findings indicate that the cocktail activator may provide a promising therapeutic approach for ALF treatment as a nanomedicine. | Na Yin Wenjun Zhang Runxiu Wei Qiang Yang Fengming He Ling Guo Min Feng | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，6： | 0 |
| 12 | Power Market Development with Considerations of Characteristics of China Power Sector显示文摘The current world trend of electric power industry reform is to establish electric power market and introduce competition mechanism. China is no exception. This paper reviewed the recent industry reform of China’s electric power sector and elaborated the necessity of establishing electric power markets first. Then it discussed the electric power market models in China. Certain important problems and observations relevant to the electric power market design were further pointed out, based on the practice experiences in Sichuan Province. | Shi Wanjian Yao Ed (Yude) Chen Fengming He Yuansen (Sichuan Provincial Electric Power Company Acres International Limited) | 2000 | Electricity2000，，2： | 0 |
| 13 | Highly stable capacitive tactile sensors with tunable sensitivity facilitated by electrostatic interaction of layered double hydroxide,MXene,and Ag NWs显示文摘A capacitive tactile sensor(CTS)has been developed by assembling a double-sided patterned dielectric layer and novel electrodes.The patterned aluminium foil-supported electrode comprises zinc-aluminium layered double hydroxides(Zn AlLDH),MXene,and Ag NWs via electrostatic interaction.This flexible device enables greater structural deformation,thereby enhancing sensitivity to a wide range of pressure.The sensitivity of the CTS can be customized to meet specific requirements by matching the microstructured electrodes with the patterned dielectric layer.An optimized sensor exhibits a sensitivity of 2.752 kPa^(–1)within 30 kPa,a response time of approximately 100 ms,and a wide detection range of 0–300 kPa.The strong physical interaction among the electrode materials ensures a reliable conductive network,ensuring the long-term stability of the sensor,even after 7500 loading and unloading cycles.Furthermore,the fabricated CTS device presents a promising prospect for the integration into wearable electronics,with the ability to effectively respond to both human activities and external physical stimuli. | SHEN GengZhe HUANG WeiQing LI HaiFeng WANG FengMing SU DaoJian LI BaiJun ZHANG BoLun LIANG Ping ZHANG Chi XIN Yue HE Xin | 2023 | Science China(Technological Sciences)2023，66，11： | 0 |
| 14 | Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop显示文摘Breast cancerhas been one of the biggest killers of women due to its susceptibility and high metastasis.Pathological observations show that malignant cancer cells frequently invade the surrounding normal tissue in collective rather than individual cell migration.1,2 For individual cell migration,it has been found that the Rho/ROCK signaling is upregulated and correlates with disease progression.3 Meanwhile,Rho activates myosin-ll and the actomyosin-mediated contraction creates tension within the cells.4,5 However,the roles of the activation of the Rho/RoCK signal pathway in collective cell migration and the precise mechanisms by which myosin-ll fine-tunes the contractility of the cells to allow for the reorganization of the cytoskeleton that drives collective cell migration,remain unclear.This study investigated whether the high cellular contractility could activate the inside-out signal transductions and how did the intracellular force contribute to the collective cell migration. | Xiang Qin Yuchen He Yixi Zhang Shun Li Tingting Li Fengming You Yiyao Liu | 2023 | Genes & Diseases2023，10，6： | 0 |
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