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| 1 | Profile improvement during CO_2 flooding in ultra-low permeability reservoirs显示文摘Gas flooding such as CO2 flooding may be effectively applied to ultra-low permeability reservoirs, but gas channeling is inevitable due to low viscosity and high mobility of gas and formation heterogeneity. In order to mitigate or prevent gas channeling, ethylenediamine is chosen for permeability profile control. The reaction mechanism of ethylenediamine with CO2, injection performance, swept volume, and enhanced oil recovery were systematically evaluated. The reaction product of ethylenediamine and CO2 was a white solid or a light yellow viscous liquid, which would mitigate or prevent gas channeling. Also, ethylenediamine could be easily injected into ultra-low permeability cores at high temperature with protective ethanol slugs. The core was swept by injection of 0.3 PV ethylenediamine. Oil displacement tests performed on heterogeneous models with closed fractures, oil recovery was significantly enhanced with injection of ethylenediamine. Experimental results showed that using ethylenediamine to plug high permeability layers would provide a new research idea for the gas injection in fractured, heterogeneous and ultra-low permeability reservoirs. This technology has the potential to be widely applied in oilfields. | Zhao Fenglan Zhang Lei Hou Jirui Cao Shujun | 2014 | Petroleum Science2014，11，2： | 12 |
| 2 | Effectiveness of Jinying capsule on pelvic inflammatory disease in patients with symptom pattern of damp and heat accumulation: a double-blinded, multicenter, randomized, placebo-controlled clinical trial显示文摘OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Traditional Chinese Medicine(TCM).METHODS: We conducted a double-blinded, multicenter, randomized, placebo-controlled clinical trial which included 155 patients diagnosed with PID and identified as symptom pattern of damp and heat accumulation. They were randomly divided into experimental group(n = 78) and control group(n = 77) according to a random number table. The treatment lasted for a period of 28 d. The experimental group was given Jinying capsules and oral levofloxacin plus oral metronidazole for first 7 d.They continued with Jinying capsules and levofloxacin placebo and metronidazole placebo for another 7 d. For the remaining 14 d, they continued with Jinying capsules only. Whereas, the control group was treated with oral levofloxacin and metronidazole and Jinying capsule placebo for the first 14 d in the same way as the experimental group and then continued with Jinying capsule placebo only for the remaining 14 d. The clinical efficacy was assessed using McCormack scale, TCM symptom pattern scores, physicochemical indexes including white blood cell and erythrocyte sedimentation rate, C-reaction protein, smear of vaginal discharge,and pelvic ultrasound.RESULTS: Comparing McCormack scale between both groups after treatment, the difference in curative effect between both groups was significant (P = 0.0269). The cure rate of the experimental group and control group is 76.32% and 59.46% respectively at week 4. Comparing TCM symptom pattern scores between both groups before and after treatment, the differences in total effective rate were both significant(P < 0.05). The curative effect rate of experimental group is 2.63% and 13.70% of the control group at week 1(P = 0.0131), and73.33% of the experimental group and 56.94% of the control group at week 4(P = 0.0369). No significant differences were found between the two groups on the Physicochemical indexes(all P >0.05). No adverse events or reactions occurred in the experimental groups.CONCLUSION: Jinying capsule can reduce the dosage of antibiotics needed for PID treatment, and improve the symptoms in PID patients. | Yang Yan Lu Yao Zhou Deping Pei Fenglan Li Qin Chen Shuqiong Wang Qiufeng Wang Yanting Jin Zhe Liu Yanxia | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 10 |
| 3 | RhMYB108,an R2R3-MYB transcription factor,is involved in ethylene-and JA-induced petal senescence in rose plants显示文摘Rose(Rosa hybrida)plants are major ornamental species worldwide,and their commercial value greatly depends on their open flowers,as both the quality of fully open petals and long vase life are important.Petal senescence can be started and accelerated by various hormone signals,and ethylene is considered an accelerator of petal senescence in rose.To date,however,the underlying mechanism of signaling crosstalk between ethylene and other hormones such as JA in petal senescence remains largely unknown.Here,we isolated RhMYB108,an R2R3-MYB transcription factor,which is highly expressed in senescing petals as well as in petals treated with exogenous ethylene and JA.Applications of exogenous ethylene and JA markedly accelerated petal senescence,while the process was delayed in response to applications of 1-MCP,an ethylene action inhibitor.In addition,silencing of RhMYB108 alter the expression of SAGs such as RhNAC029,RhNAC053,RhNAC092,RhSAG12,and RhSAG113,and finally block ethylene-and JA-induced petal senescence.Furthermore,RhMYB108 was identified to target the promoters of RhNAC053,RhNAC092,and RhSAG113.Our results reveal a model in which RhMYB108 functions as a receptor of ethylene and JA signals to modulate the onset of petal senescence by targeting and enhancing senescence-associated gene expression. | Shuai Zhang Qingcui Zhao Daxing Zeng Jiehua Xu Hougao Zhou Fenglan Wang Nan Ma Yonghong Li | 2019 | Horticulture Research2019，6，1： | 10 |
| 4 | A Genomic Variation Map Provides Insights into the Genetic Basis of Spring Chinese Cabbage (Brassica rapa ssp.pekinensis)Selection显示文摘Chinese cabbage is the most consumed leafy crop in East Asian countries.However,premature bolting induced by continuous low temperatures severely decreases the yield and quality of the Chinese cabbage, and therefore restricts its planting season and geographic distribution.In the past 40years,spring Chinese cabbage with strong winterness has been selected to meet the market demand.Here,we report a genome variation map of Chinese cabbage generated from the resequencing data of 194 geographically diverse accessions of three ecotypes.In-depth analyses of the selection sweeps and genome-wide patterns revealed that spring Chinese cabbage was selected from a specific population of autumn Chinese cabbage around the area of Shandong peninsula in northern China.We identified 23 genomic loci that underwent intensive selection,and further demonstrated by gene expression and haplotype analyses that the incorporation of elite alleles of VERNALISATION INSENTIVE 3.1(BrVIN3.1)and FLOWER LOCUS C 1(BrFLC1)is a determinant genetic source of variation during selection.Moreover,we showed that the quantitative response of BrVIN3.1 to cold due to the sequence variations in the cis elements of the BrVlN3.1 promoter significantly contributes to bolting-time variation in Chinese cabbage.Collectively, our study provides valuable insights into the genetic basis of spring Chinese cabbage selection and will facilitate the breeding of bolting-resistant Varieties by molecular-marker-assisted selection,transgenic or gene editingapproaches. | Tongbing Su Weihong Wang Peirong Li Bin Zhang Pan Li Xiaoyun Xin Honghe Sun Yangjun Yu Deshuang Zhang Xiuyun Zhao Changlong Wen Gang Zhou Yuntong Wang Hongkun Zheng Shuancang Yu Fenglan Zhang | 2018 | Molecular Plant2018，11，11： | 6 |
| 5 | Anatomic Study of Female Sterility of Pinus tabulaeformis Carr.显示文摘The anatomic research on the mutant clone of Pinus tabulaeformis Carr. in the seed orchard in Xingcheng, LiaoningProvince was carried out. The female cone of the mutant clone looked like normal, but its ovules degenerated in the early stage. Thispaper tries to find out the reason and time of ovule abortion. It seems that the ovule abortion is probably caused by female sterilitybecause the microspores of this mutant clone were normal. Through the serial observations on the one-year-old macrosporangiatesand the ovules of two-year-old female cones of mutant and normal clone, it is found that the reason of ovule abortion in mutant cloneis the failure of the mitosis of free nuclei in the female gametophyte, and the time is about in the early April. | Cheng Pengjun Li Fenglan Zheng CaixiaCollege of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, P. R. China | 2003 | Forestry Studies in China2003，5，1： | 5 |
| 6 | Characteristics of remaining oil viscosity in water-and polymer-flooding reservoirs in Daqing Oilfield显示文摘The experimental analysis of 21 crude oil samples shows a good correlation between high molecular-weight hydrocarbon components (C 40+) and viscosity.Forty-four remaining oil samples extracted from oil sands of oilfield development coring wells were analyzed by high-temperature gas chromatography (HTGC),for the relative abundance of C 21-,C 21-C 40 and C 40+ hydrocarbons.The relationship between viscosity of crude oil and C 40+ (%) hydrocarbons abundance is used to expect the viscosity of remaining oil.The mobility characteristics of remaining oil,the properties of remaining oil,and the next displacement methods in reservoirs either water-flooded or polymer-flooded are studied with rock permeability,oil saturation of coring wells,etc.The experimental results show that the hydrocarbons composition,viscosity,and mobility of remaining oil from both polymer-flooding and water-flooding reservoirs are heterogeneous,especially the former.Relative abundance of C 21- and C 21-C 40 hydrocarbons in polymer-flooding reservoirs is lower than that of water-flooding,but with more abundance of C 40+ hydrocarbons.It is then suggested that polymer flooding must have driven more C 40- hydrocarbons out of reservoir,which resulted in relatively enriched C 40+,more viscous oils,and poorer mobility.Remaining oil in water-flooding reservoirs is dominated by moderate viscosity oil with some low viscosity oil,while polymer-flooding mainly contained moderate viscosity oil with some high viscosity oil.In each oilfield and reservoir,displacement methods of remaining oil,viscosity,and concentration by polymer-solution can be adjusted by current viscosity of remaining oil and mobility ratio in a favorable range.A new basis and methods are suggested for the further development and enhanced oil recovery of remaining oil. | XU ZhengShun,ZHANG JuHe,FENG ZiHui,FANG Wei & WANG FengLan Exploration and Development Research Institute,Daqing Oilfield Company Ltd.,Daqing 163712,China | 2010 | Science China Earth Sciences2010，53，1： | 3 |
| 7 | Identification of long noncoding RNAs involved in resistance to downy mildew in Chinese cabbage显示文摘Brassica downy mildew,a severe disease caused by Hyaloperonospora brassicae,can cause enormous economic losses in Chinese cabbage(Brassica rapa L.ssp.pekinensis)production.Although some research has been reported recently concerning the underlying resistance to this disease,no studies have identified or characterized long noncoding RNAs involved in this defense response.In this study,using high-throughput RNA sequencing,we analyzed the disease-responding mRNAs and long noncoding RNAs in two resistant lines(T12–19 and 12–85)and one susceptible line(91–112).Clustering and Gene Ontology analysis of differentially expressed genes(DEGs)showed that more DEGs were involved in the defense response in the two resistant lines than in the susceptible line.Different expression patterns and proposed functions of differentially expressed long noncoding RNAs among T12–19,12–85,and 91–112 indicated that each has a distinct disease response mechanism.There were significantly more cis-and trans-functional long noncoding RNAs in the resistant lines than in the susceptible line,and the genes regulated by these RNAs mostly participated in the disease defense response.Furthermore,we identified a candidate resistance-related long noncoding RNA,MSTRG.19915,which is a long noncoding natural antisense transcript of a MAPK gene,BrMAPK15.Via an agroinfiltration-mediated transient overexpression system and virus-induced gene silencing technology,BrMAPK15 was indicated to have a greater ability to defend against pathogens.MSTRG.19915-silenced seedlings showed enhanced resistance to downy mildew,probably because of the upregulated expression of BrMAPK15.This research identified and characterized long noncoding RNAs involved in resistance to downy mildew,laying a foundation for future in-depth studies of disease resistance mechanisms in Chinese cabbage. | Bin Zhang Tongbing Su Peirong Li Xiaoyun Xin Yunyun Cao Weihong Wang Xiuyun Zhao Deshuang Zhang Yangjun Yu Dayong Li Shuancang Yu Fenglan Zhang | 2021 | Horticulture Research2021，8，1： | 3 |
| 8 | Variable structure control for three-variable autocatalytic reaction显示文摘In this paper, two irreversible exothermic autocatalytic reactions which carry out in continuous stirred tank reactor (CSTR) are considered. A differential-algebraic system is applied to model these chemical reactions. The stability and the dynamic behavior are studied for the differential-algebraic system. The Hopf bifurcation appears when the parameter exceeds a critical value. In order to eliminate this complex behavior, the differential-algebraic system is described by a single-input and single-output system with parameter varying within definite intervals, and then variable structure control with sliding mode based on a special power reaching law is designed to stabilize this chemical system. Numerical simulations are given to illustrate the effectiveness of the method. | Hong NIU Qingling ZHANG Chunyu YANG Fenglan BAI | 2013 | 控制理论与应用(英文版)2013，11，3： | 2 |
| 9 | A Method of Improving Seismic Data Resolution:Comprehensive Inversion of Well logging and Seismic Data显示文摘AMethodofImprovingSeismicDataResolution:ComprehensiveInversionofWellloggingandSeismicDataZhangYufen;HongFeng(DepartmentofAppl... | Zhang Yufen Hong Feng(Department of Applied Geophysics, China University of Geosciences, Wuhan 430074)Li Fenglan Qing Guangsheng(Geological Survey Division, Zhongyuan Petroleum Exploration Bureau, Puyang 457001) | 1996 | Journal of Earth Science1996，15，2： | 2 |
| 10 | RAPD analysis on the four kinds of color-flowered Salvia splendens Ker-Gawl显示文摘In this study,we used RAPD to analyze four kinds of color-flowered Salvia splendens Ker-Gawl,and the optimal RAPD reaction conditions were the optimal reaction mixture(25μL total volume)that contained 2.0μL 10×buffer,0.45 mmol·L^(-1) dNTPs, 2.0 mmol·L^(-1)Mg^(2+),2 U Taq DNA polymerase,0.30 umol·L^(-1)primer and 40 ng genomic DNA.Total 84 bands were amplified from 12 primers used,and the differential bands had 28 bands,which was 33% of total bands.In cluster group analysis,the four kinds of color-flowered were divided into two styles.One style is that the red color and red-white color were grouped together,then they grouped with purple color into one cluster,and the white color was another style. | HU Guofu YUAN Qiang LI Fenglan WEI Qi HU Baozhong | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，2： | 1 |
| 11 | The Effects of the organic groups attached at the silicone atoms of the organosilane - based Gemini nonionic surfactants on their surface activities 显示文摘 | XING FENGLAN GAO YUEYUE XU QUN | 2014 | Journal of Surfactants and Detergents2014，17，： | 1 |
| 12 | The cystic fibrosis transmembrane conductance regulator as a biomarkerin non-small cell lung cancer显示文摘 | Jin Li Jie Zhang Xiaohua Jiang Xiaoshun Shi Jianfei Shen Fenglan Feng Jingyi Chen Guihong Liu Ping He Juhong Jiang Lai Tsang Yan Wang Rafael Rosell Long Jiang Jianxing He Hsiao Chan | 2015 | International Journal of Oncology2015，，： | 1 |
| 13 | Genome-wide analysis of changes in miRNA and target gene expression reveals key roles in heterosis for chinese cabbage biomass显示文摘Heterosis is a complex phenomenon in which hybrids show better phenotypic characteristics than their parents do.Chinese cabbage(Brassica rapa L.spp.pekinensis)is a popular leafy crop species,hybrids of which are widely used in commercial production;however,the molecular basis of heterosis for biomass of Chinese cabbage is poorly understood.We characterized heterosis in a Chinese cabbage hybrid cultivar and its parental lines from the seedling stage to the heading stage;marked heterosis of leaf weight and biomass yield were observed.Small RNA sequencing revealed 63 and 50 differentially expressed microRNAs(DEMs)at the seedling and early-heading stages,respectively.The expression levels ofthe majority of miRNA clusters in the hybrid were lower than the mid-parent values(MPVs).Using degradome sequencing,we identi fied 1,819 miRNA target genes.Gene ontology(GO)analyses demonstrated that the target genes ofthe MPV-DEMs and low parental expression level dominance(ELD)miRNAs were signi ficantly enriched in leaf morphogenesis,leaf development,and leaf shaping.Transcriptome analysis revealed that the expression levels of photosynthesis and chlorophyll synthesis-related MPV-DEGs(differentially expressed genes)were signi ficantly different in the F_(1) hybrid compared to the parental lines,resulting in increased photosynthesis capacity and chlorophyll content in the former.Furthermore,expression of genes known to regulate leaf development was also observed at the seedling stage.Arabidopsis plants overexpressing BrGRF4.2 and bra-miR396 presented increased and decreased leaf sizes,respectively.These results provide new insight into the regulation of target genes and miRNA expression patterns in leaf size and heterosis for biomass of B.rapa. | Peirong Li Tongbing Su Deshuang Zhang Weihong Wang Xiaoyun Xin Yangjun Yu Xiuyun Zhao Shuancang Yu Fenglan Zhang | 2021 | Horticulture Research2021，8，1： | 1 |
| 14 | Prepara- tion and characteristics of interferon alpha poly ( lactic-co- glycolic acid) microspheres 显示文摘 | YANG Fan SONG Fenglan PAN Yufang | 2010 | J Microencapsul2010，27，2： | 1 |
| 15 | Technological ehanllenges for CO2 EOR in China显示文摘 | Yue Xiang-an Zhao Renbao Zhao Fenglan | 2007 | Science Paper Online2007，2，7： | 1 |
| 16 | Hierarchically porous CMC/rGo/CNFs aerogels for leakage-proof mirabilite phase change materials with superior energy thermal storage显示文摘As a kind of essential hydrated salt phase change energy storage materials,mirabilite with high energy storage density and mild phase-transition temperature has excellent application potential in the problems of solar time and space mismatch.However,there are some disadvantages such as supercooling,substantial phase stratification and leakage problem,limiting its further applications.In this work,for the preparation of shaped mirabilite phase change materials(MPcMs),graphene(GO),sodium carboxymethyl cellulose(CMC),and carbon nanofibers(CNFs)were used as starting materials to prepare lightweight CMC/rGO/CNFs carbon aerogel(CGCA)as support with stable shape,high specific surface area,and well-arranged hierarchically porous structure.The results show that CGCA has regular layered plentiful pores and stable foam structure,and the pore and sheet interspersed structure in CGCA stabilizes PcMs via capillary force and surface tension.The hydrophilic aerogels supported MPCMs decrease mirabilite leaking and reduce supercooling to around 0.7-1C.The latent heats of melting and crystallization of CGCA-supported mirabilite phase change materials(CGCA-PCMs)are 157.1 and 114.8 J-g-1,respectively.Furthermore,after 1500 solid-liquid cycles,there is no leakage,and the retention rate of crystallization latent heat is 45.32%,exhibiting remarkable thermal cycling stability. | Fenglan CHEN Xin LIU Zhengya WANG Shengnian TIE Chang-An WANG | 2022 | Frontiers of Materials Science2022，16，4： | 1 |
| 17 | Application of the Topological Index with comparing the Biological Sequence 显示文摘 | FENGLAN BAI BO LIAO TIANMING WANG | 2006 | Mathematical Biosciences2006，21，4： | 1 |
| 18 | Reservoir-forming conditions and key exploration & development techniques for Xushen gas field in Northeast China显示文摘Exploration and development of volcanic gas reservoirs is a world-class problem,and less experience can be learned at home and abroad.Through study of reservoir-forming conditions of Xushen gas field,four sets of hydrocarbon source rocks,mainly mudstone and coal seam of Shahezi Formation,are identified in this gas field;its cap rocks are mudstone in Member 2 of Denglouku Formation,and Member 1 and Member 2 of Quantou Formation.By simulating reservoir-forming history,four filling periods of the Xushen gas field are determined,and the most favorable exploration targets are crater areas with structural highs,large thickness and good physical properties.On the basis of diagenetic mechanism study,the criteria of sequence series,lithology identification and reservoir types of gas reservoirs have been established;the volcanic rock bodies have been carefully depicted and the distribution laws of effective reservoirs of gas pools have been figured out.Based on evaluating reservoir-permeability characteristics of reservoirs,the gas well productivity characteristics(mainly type II,III and IV wells)have been identified,and the optimum design technology for volcanic gas reservoir development has been developed.The gas reservoirs in all blocks of Xushen gas field are classified into three types:singlebody gas reservoir model,disconnected multi-body gas reservoir model and interconnected multi-body gas reservoir model.Stimulation technologies,including multi-layer fracturing of vertical well,staged fracturing of open-hole horizontal well and volume fracturing,have been developed.According to gas well production performance,pressure change,well-controlled reserves and spatial distribution of volcanic bodies,combined with numerical simulation and prediction of gas reservoirs,the evaluation method of residual potential of volcanic gas reservoirs has been formed.Key technologies for effective exploration and development of complex volcanic gas reservoirs have been established and perfected,and bring good development effect.The research results can provide guidance and reference for exploration and development of similar gas reservoirs. | Fenglan Wang Yongzhuo Wang Xuemin Zhou Changhai Yin Ping Shu Baojun Cao Yingkang Zhu | 2019 | Petroleum Research2019，4，2： | 1 |
| 19 | Surveillance of enteric pathogens in imported seafood and environmental surfaces in five seafood markets before the outbreak of COVID-19显示文摘To monitor the presence of enteric pathogens in imported seafood,a total of 140 seafood samples imported from eight overseas countries were collected from Beijing,Dalian,Shanghai,Guangzhou,and Wuhan seafood markets from June to November 2019.Additionally,116 viral,environmental swab samples were also collected from the Wuhan and Guangzhou seafood markets.Five typical enteric bacterial pathogens(Aeromonas spp.,Shigella spp.,Salmonella spp.,Vibrio spp.,and Listeria monocytogenes)and four viruses(Rotavirus,Norovirus,Astrovirus,and Sapovirus)were detected positive.Results showed that eight Vibrio parahaemolyticus isolates appeared in seafood imported to Dalian,Wuhan,Shanghai,Guangzhou,and Beijing.In contrast,Vibrio fluvialis and Aeromonas were isolated in another two samples.Norovirus was detected in one oyster sample imported from France and environmental surface in Guangzhou.The remaining pathogens were negative in all the samples being tested.With 120 V.parahaemolyticus isolates from the above countries,the genomic analysis revealed that sequence type ST1152 isolates imported from Canada were clustered with two V.parahaemolyticus isolates from Canada.This study presented the first microbiological analysis of the Wuhan seafood market before the outbreak of COVID-19,which demonstrated that supervision should be strengthened to prevent enteric pathogens via imported seafood. | Songzhe Fu Wei Wang Qingyao Wang Fenglan He Jingwei Hao Bo Pang | 2021 | Biosafety and Health2021，3，4： | 1 |
| 20 | Current Status and Prospects of ASP Flooding in Daqing Oil Fields 显示文摘 | Wang Fenglan and Yang Zhenyu | | SPE1143430，，： | 1 |
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