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| 1 | The effect of carbon nanotubes on osteogenic functions of adipose-derived mesenchymal stem cells in vitro and bone formation in vivo compared with that of nano-hydroxyapatite and the possible mechanism显示文摘It has been well recognized that the development and use of artificial materials with high osteogenic ability is one of the most promising means to replace bone grafting that has exhibited various negative effects.The biomimetic features and unique physiochemical properties of nanomaterials play important roles in stimulating cellular functions and guiding tissue regeneration.But efficacy degree of some nanomaterials to promote specific tissue formation is still not clear.We hereby comparatively studied the osteogenic ability of our treated multiwalled carbon nanotubes(MCNTs)and the main inorganic mineral component of natural bone,nano-hydroxyapatite(nHA)in the same system,and tried to tell the related mechanism.In vitro culture of human adiposederived mesenchymal stem cells(HASCs)on the MCNTs and nHA demonstrated that although there was no significant difference in the cell adhesion amount between on the MCNTs and nHA,the cell attachment strength and proliferation on the MCNTs were better.Most importantly,the MCNTs could induce osteogenic differentiation of the HASCs better than the nHA,the possible mechanism of which was found to be that the MCNTs could activate Notch involved signaling pathways by concentrating more proteins,including specific bone-inducing ones.Moreover,the MCNTs could induce ectopic bone formation in vivo while the nHA could not,which might be because MCNTs could stimulate inducible cells in tissues to form inductive bone better than nHA by concentrating more proteins including specific bone-inducing ones secreted from M2 macrophages.Therefore,MCNTs might be more effective materials for accelerating bone formation even than nHA. | Zhipo Du Xinxing Feng Guangxiu Cao Zhending She Rongwei Tan Katerina E.Aifantis Ruihong Zhang Xiaoming Li | 2021 | Bioactive Materials2021，6，2： | 3 |
| 2 | 显示文摘 | Feng Xinxing Zhang Lili Chen Jianyong | 2007 | International Journal of Biological Macromolecules2007，40，： | 1 |
| 3 | A novel process for preparing expanded Polytetrafluoroethylene(ePTFE) micro-porous membrane through ePTFE/ePTFE co-stretching technique显示文摘 | Yuhai Guo Jianyong Chen Xinmin Hao Jianchun Zhang Xinxing Feng Huapeng Zhang | 2007 | Journal of Materials Science2007，，6： | 1 |
| 4 | Role of extracellular protein in the formation and stability of aerobic granules 显示文摘 | Zhang Lili Feng Xinxing Zhu Nanwen | 2007 | Enzyme and Microbial Technology2007，41，5： | 1 |
| 5 | Preparation and Characterization of novel nanocomposite films formed from silk fibroin and nano TiO2 显示文摘 | Feng Xinxing Zhang Lili Chen Jianyong | 2007 | International Journal of Biological Macromolecules2007，40，2： | 1 |
| 6 | LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral显示文摘Background:Oral squamous cell carcinoma(OSCC)is a common malignant tumor.Recently,Laminin Gamma 2(LAMC2)has been shown to be abnormally expressed in OSCC;however,how LAMC2 signaling contributes to the occurrence and development of OSCC and the role of autophagy in OSCC has not been fully explored.This study aimed to analyze the role and mechanism of LAMC2 signaling in OSCC and the involvement of autophagy in OSCC.Methods:To explore the mechanism by which LAMC2 is highly expressed in OSCC,we used small interfering RNA(siRNA)to knock down LAMC2 to further observe the changes in the signaling pathway.Furthermore,we used cell proliferation assays,Transwell invasion assays,and wound-healing assays to observe the changes in OSCC proliferation,invasion,and metastasis.RFP-LC3 was used to detect the level of autophagy intensity.A cell line-derived xenograft(CDX)model was used to detect the effect of LAMC2 on tumor growth in vivo.Results:This study found that the level of autophagy was correlated with the biological behavior of OSCC.The downregulation of LAMC2 activated autophagy and inhibited OSCC proliferation,invasion,and metastasis via inhibiting the PI3K/AKT/mTOR pathway.Moreover,autophagy has a dual effect on OSCC,and the synergistic downregulation of LAMC2 and autophagy can inhibit OSCC metastasis,invasion,and proliferation via the PI3K/AKT/mTOR pathway.Conclusions:LAMC2 interacts with autophagy to regulate OSCC metastasis,invasion,and proliferation via the PI3K/AKT/mTOR pathway.LAMC2 down-regulation can synergistically modulate autophagy to inhibit OSCC migration,invasion,and proliferation. | FAYU SHAN LANLAN LIANG CHONG FENG HONGBAO XU ZIROU WANG WEILI LIU LINGLING PU ZHAOLI CHEN GANG CHEN XINXING WANG | 2023 | Oncology Research2023，31，4： | 1 |
| 7 | Role of extracellular protein in the formation and stability of aero- bic granules显示文摘 | Zhang Lili Feng Xinxing Zhu Nanwen | 2007 | Enzyme and Microbial Technology2007，1，5： | 1 |
| 8 | Measurement of One Proton Transfer Reaction 208Pb(7Li,6He)209Bi in Deep Sub-barrier Region显示文摘Due to the limit of the intensity and quality of the radioactive ion beam(RIB),it is a difficult task to extract the optical model potentials(OMPs)of halo nuclear systems directly from the elastic scattering measurement.In view of this fact,the transfer reaction was tried to be used as an alternative method to extract and stud- | LIN Chengjian YANG Lei JIA Huiming MA Nanru SUN Lijie WANG Dongxi XU Xinxing YANG Feng ZHANG Huanqiao LIU Zuhua | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 9 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 10 | Systematic Study of Experimental Fusion Barrier Based on Wong Formula显示文摘Coulomb barrier is the critical point between repulsive Coulomb potential and attractive nuclear potential in central collisions.Nuclear force plays the decisive role in inner barrier region,and the external barrier region is dominated by the Coulomb force.This barrier is usually named as fusion barrier(for light and medium mass heavyion systems)or capture barrier(heavy systems)when taking into account other effects,such as the quasi-fission or fission. | WEN Peiwei LIN Chengjian JIA Huiming CUI Danteng YANG Feng MA Nanru SUN Lijie WANG Dongxi ZHONG Fupeng SUN Haohan YANG Lei XU Xinxing | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 11 | Energy Dependence of Optical Potentials of Halo System 6He+64Zn显示文摘The angular distributions of the transfer reactions of 63Cu(7Li,6 He)64Zn were measured at energies around the Coulomb barrier,to extract and study the optical model potential(OMP)of halo system 6 He+64Zn in the exit channel.Due to the limit of the intensity and quality of the radioactive ion beam(RIB),it is a difficult task to extract the OMPs of halo | YANG Lei LIN Chengjian JIA Huiming MA Nanru SUN Lijie WANG Dongxi XU Xinxing YANG Feng ZHANG Huanqiao LIU Zuhua | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 12 | MUSTA:MUltilayer Silicon Telescope Array for Study of Elastic Scattering and Breakup Reaction of Weakly Bound Nuclei at Energy near Coulomb Barrier显示文摘Nowadays the reaction mechanism study of weakly bound nuclei has been one of the frontier problems of nuclear physics.For weakly bound nucleus,the nuclear force and Coulomb force is so weak that in the process of interaction with target nucleus,weakly bound nucleus may breakup into small pieces easily,and such breakup effect can bring some unconventional physical phenomena to weakly bound nucleus near the drip line:such as halo/skin structure,the disappearance of old magic number and the appearance of new magic number,etc. | MA Nanru LIN Chengjian JIA Huiming CUI Danteng YANG Feng WEN Peiwei WANG Dongxi SUN Lijie ZHONG Fupeng SUN Haohan YANG Lei XU Xinxing | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 13 | Near-barrier Fusion Evaporation and Fission of 28Si+174Yb and 32S+170Er显示文摘Heavy-ion induced fusion-fission reactions at energies around the Coulomb barrier have attracted much attention[1-2],due to many degrees of freedom involved in the interaction processes.It has been experimentally proved that the coupled interactions of some intrinsic motions and relative motion play a significant role in the process | WANG Dongxi JIA Huiming LIN Chengjian YANG Feng XU Xinxing YANG Lei MA Nanru SUN Lijie BAO Pengfei LIU Zuhua ZHANG Huanqiao | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 14 | High-lying excited states in ^10Be from the ^9Be(^9Be,^10Be)^8Be reaction显示文摘A transfer-reaction experiment of ~9Be(~9Be,^(10)Be)~8Be was performed at a beam energy of 45 Me V.Excited states in ^(10)Be up to 18.80 Me V are produced using missing mass and invariant mass methods.Most of the observed high-lying resonant states,reconstructed from theα+~6He and t+~7Li decay channels,agree with the previously reported results.In addition,two new resonances at 15.6 and 18.8 Me V are identified from the present measurement.The 18.55 Me V state is found to decay into both the t + ~7Lig:s: and t + ~7Li?(0.478 MeV) channels, with a relative branching ratio of 0:93 ± 0:33. Further theoretical investigations are encouraged to interpret this new information on cluster structure in neutron-rich light nuclei. | Wei Jiang YanLin Ye ZhiHuan Li ChengJian Lin QiTe Li YuCheng Ge JianLing Lou DongXing Jiang Jing Li ZhengYang Tian Jun Feng Biao Yang ZaiHong Yang Jie Chen HongLiang Zang Qiang Liu PengJie Li ZhiQiang Chen Yun Zhang Yang Liu XiaoHui Sun Jing Ma HuiMing Jia XinXing Xu Lei Yang NanRu Ma LiJie Sun | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 0 |
| 15 | THE PREPARATION AND STUDY ON THE NANO-TiO2/SILK FIBROIN COMPOSITE FILMS BY THE SOL-GEL METHOD显示文摘 | FENG Xinxing CHEN Jianyong YU Chunhua | 2006 | Chinese Journal of Reactive Polymers2006，15，1： | 0 |
| 16 | Protective equipment for emergency rescue in alpine-cold region显示文摘Alpine-cold regions are characterized as hypoxia,strong wind,heavy rain,cold climate,huge temperature difference between day and night,and vertical climate. All these make it difficult for an emergency rescue when a natural disaster such as earthquake happens. Based on the characteristics of emergency rescue in alpinecold region,several multifunctional protective equipments have been developed by the Quartermaster Equipment Institute of General Logistics Departmen(tGLD)of the Chinese People's Liberation Army(CPLA). These equipments are lightweight,durable and environment adaptable. | Ma Tian Feng Xinxing Wang Qizhi Hao Limin | 2013 | Engineering Sciences2013，11，2： | 0 |
| 17 | MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy显示文摘Microfibrillar-associated protein 2(MFAP2)is a small glycoprotein that is involved in vascular development and metabolic disease.The present study aims to explore the regulatory role of MFAP2 in the development and progression of oral squamous cell carcinoma(OSCC),including the underlying mechanisms.MFAP2 expression and its association with the progression of OSCC are explored using bioinformatics.MFAP2 expression in OSCC tissues is detected by immunohistochemical staining.SCC15 cell migration,invasion,apoptosis,proliferation,and viability are detected by wound healing,Transwell,flow cytometry,colony formation,and cell counting kit-8 assays.An in vivo experiment is used to detect tumor formation.Western blot analysis is used to determine MFAP2’s regulatory role in autophagy and the Wnt/β-catenin signaling pathway.MFAP2 is highly expressed in SCC15 cells and OSCC tissues,which correlates positively with the poor prognosis of patients with OSCCs.Functionally,MFAP2 promotes oncogenic autophagy to increase cell invasion,migration,and proliferation but inhibits apoptosis in SCC15 cells and promotes tumor growth in vivo.Mechanistically,MFAP2 upregulates autophagy and Wnt/β-catenin signaling to stimulate OSCC development.Intriguingly,regulation of Wnt/β-catenin signaling dependent on autophagy contributes to the malignant behaviors of SCC15 cells.MFAP2 could serve as a novel biomarker for OSCC and could affect OSCC tumorigenesis and development via autophagic regulation of Wnt/β-catenin signaling. | Hao Zhang Si Shen Chong Feng Gang Chen Xinxing Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 0 |
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