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| 1 | Treatment of colorectal cancer in the elderly显示文摘Colorectal cancer has a high incidence, and approxi-mately 60% of colorectal cancer patients are older than 70, with this incidence likely increasing in the near future. Elderly patients(> 70-75 years of age) are a very heterogeneous group, ranging from the very fit to the very frail. Traditionally, these patients have often been under-treated and recruited less frequently to clinical trials than younger patients, and thus are underrepresented in publications about cancer treatment. Recent studies suggest that fit elderly patients can be treated in the same way as their younger counterparts, but the treatment of frail patients with comorbidities is still a matter of controversy. Many factors should be taken into account, including fitness for treatment, the wishes of the patient and family, and quality of life. This review will focus on the existing evidence for surgical, oncologic, and palliative treatment in patients over 70 years old with colorectal cancer. Careful patient assessment is necessary in order to individualize treatment approach, and this should rely on a multidisciplinary process. More well-designed controlled trials are needed in this patient population. | Monica Millan Sandra Merino Aleidis Caro Francesc Feliu Jordi Escuder Tani Francesch | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 9 |
| 2 | Management of pancreatic cancer in the elderly显示文摘Currently, pancreatic adenocarcinoma mainly occurs after 60 years of age, and its prognosis remains poor despite modest improvements in recent decades. The aging of the population will result in a rise in the incidence of pancreatic adenocarcinoma within the next years. Thus, the management of pancreatic cancer in the elderly population is gaining increasing relevance. Older cancer patients represent a heterogeneous group with different biological, functional and psychosocial characteristics that can modify the usual management of this disease, including pharmacokinetic and pharmacodynamic changes, polypharmacy, performance status, comorbidities and organ dysfunction. However, the biological age, not the chronological age, of the patient should be the limiting factor in determining the most appropriate treatment for these patients. Unfortunately, despite the increased incidence of this pathology in older patients, there is an underrepresentation of these patients in clinical trials, and the management of older patients is thus determined by extrapolation from the results of studies performed in younger patients. In this review, the special characteristics of the elderly, the multidisciplinary management of localized and advanced ductal adenocarcinoma of the pancreas and the most recent advances in the management of this condition will be discussed, focusing on surgery, chemotherapy, radiation and palliative care. | Oliver Higuera Ismael Ghanem Rula Nasimi Isabel Prieto Laura Koren Jaime Feliu | 2016 | World Journal of Gastroenterology2016，22，2： | 2 |
| 3 | Comparison of rates of general corrosion and maximum pitting penetration on concrete embedded steel reinforcement显示文摘 | J.A. González C. Andrade C. Alonso S. Feliu | 1995 | Cement and Concrete Research1995，，2： | 2 |
| 4 | Considerations on reproducibility of potential and corrosion rate measurements in reinforced concrete显示文摘 | GonzalezJ A Miranda J M Feliu S | 2004 | Corros Sci2004，46，： | 1 |
| 5 | Correlation between the surface chemistry of annealed IF steel and the growth of a galvanneal coating显示文摘 | Feliu S Jr Perez-Revenga M L | 2005 | Acta Materilia2005，53，9： | 1 |
| 6 | CD66a ( CEACAM1 ) expression by mouse natural killer ceils显示文摘 | Thirion G Feliu AA CoutelierJP | 2008 | Immunology2008，125，4： | 1 |
| 7 | UFT (tegafur -uracil)in rectal cancer 显示文摘 | Casado E Pfeiffer P Feliu J | 2008 | Ann Oncol2008，19，8： | 1 |
| 8 | Mechanism and kinetics of the electrochemical CO adlayer oxidation on Pt( 111 ) 显示文摘 | Lebedeva N P Koper M T M Feliu J M | 2002 | J Electroanal Chem2002，524，： | 1 |
| 9 | EIS study of the corrosion behaviour of zinc- based coatings on steel in quiescent 3% NaCl solution 显示文摘 | Barranco V Feliu S J | 2004 | Corrosion Science2004，46，： | 1 |
| 10 | 显示文摘 | Feliu S Gonzalez J A Miranda J M | 2005 | Corrosion Science2005，47，： | 1 |
| 11 | Formic acid self-poisoning on adatom-modified stepped electrodes显示文摘 | Macia M D Herrero E Feliu J M | 2002 | Electrochimica Acta2002，47，2223： | 1 |
| 12 | UFT ( tegafur- uracil) in rectal cancer 显示文摘 | Casado E Pfeiffer P Feliu J | 2008 | Ann 0ncol2008，19，8： | 1 |
| 13 | The Protective Action of Two Vapor-Phase Inhibitors on the Corrosion of Mild Steel显示文摘 | Bastidas J M Mora E M Feliu S | 1990 | Werkstoffe Korrosion1990，41，9： | 1 |
| 14 | Study of the electrochemical noise generated by the mild steel/zinc - rich paint/NaCl solution system 显示文摘 | Bastidas J M Feliu S Jr Morcillo M | 1990 | Progress in Organic Coatings1990，18，3： | 1 |
| 15 | On the different adsorption behavior of bismuth, sulfur, selenium and tellurium on a Pt(775) stepped surface显示文摘 | Herrero E Climent V Feliu J M | 2000 | Electrochemistry Communications2000，2，： | 1 |
| 16 | XEI,OX (capecitabine plus oxaliplatin) as first - line treatment for elderly patients over 70 years of age with ad- vanced colorectal cancer 显示文摘 | Feliu J Salud A Escudero P | 2006 | Br J Cancer2006，94，7： | 1 |
| 17 | Some tuning rules for PI^λ controllers robust to gain or time constant changes 显示文摘 | Monje C A Vinagre B M Chen Y Q Feliu V | 2004 | Nonlinear Dynamics (S0924-090X)2004，38，： | 1 |
| 18 | Considerations on reproducibility of potential and corrosion rate measurements in reinforced concrete显示文摘 | GONZALEZ J A MIRANDA J M FELIU S | 2004 | Corros Sci2004，46，10： | 1 |
| 19 | Phase Ⅱ randomised trial of raltitrexed-oxaliplatin vs raltitrexed irinotecan as first-line treatment n advanced colorectal cancer显示文摘 | Feliu J Castanon C Salud A | 2005 | Br J Cancer2005，93，11： | 1 |
| 20 | Effect of distance from sea on atmospheric corrosion rate显示文摘 | Feliu S Morcillo M Chico B | 1999 | Corrosion1999，55，： | 1 |
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