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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Investigation of the rapid chloride permeability test显示文摘 | FELDMAN R F CHAN G W BROUSSEAU R J | 1994 | ACI Materials Journal1994，91，3： | 1 |
| 3 | Hydride generation activity of arsenosugars and thioarsenicals显示文摘 | REGMI R MILNE B F FELDMAN J | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 4 | A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies显示文摘 | Rizzieri D A Feldman E DiPersio J F | 2008 | Clin Cancer Res2008，14，9： | 1 |
| 5 | Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells显示文摘 | Li Y Y Mctieman C F Feldman A M | 1999 | Carvasc Res1999，42，1： | 1 |
| 6 | Concrete Science显示文摘 | V S Ramachandran R F Feldman J J Beaudoin | 1981 | Hayden & Son Ltd1981，，： | 1 |
| 7 | Intra-and extraosseous malignant histiocytoma(malignant fibrous xanthoma)显示文摘 | Feldman F Norman D | | RADIOLOGY0，，： | 1 |
| 8 | Postcon- trast MRI of cranial meninges: leptomeningitis versus pachymeningitis 显示文摘 | Kioumehr F Dadsetan MR Feldman N | 1995 | J Comput Assist Tomogr1995，19，5： | 1 |
| 9 | Meniscal position onroutine MR imaging of the knee显示文摘 | Miller TT Staron RB Feldman F | 1997 | Skeletal Radiol1997，26，： | 1 |
| 10 | Analysis of magnesiumlike spectra from Mo XXXI to Cs XlIV显示文摘 | EKBERG J O FELDMAN U SEELY J F | 1991 | Physiea Scripta1991，43，1： | 1 |
| 11 | Psychophysiology显示文摘 | Gordon I Zagoory-Sharon O Schneiderman I Leckman J F Weller A Feldman R | 2008 | 45(3):3492008，45，3： | 1 |
| 12 | Intra and extraosseous malignant histiocytoma (malignant fibrous xanthoma)显示文摘 | Feldman F Norman D | 1972 | Radiology1972，104，3： | 1 |
| 13 | Bi-directional inflorescence development in Arabidopsis thaliana:acropetal initiation of flowers and basipetal initiation of paraclades显示文摘 | Hempel F D Feldman L J | 1994 | Planta1994，192，： | 1 |
| 14 | The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma显示文摘 | Alward WL Feldman F Cashwell F | 1998 | Am J Ophthalmol1998，126，： | 1 |
| 15 | Serum endostatin levels are elevated and correlate with serum vascular endothelial growth factor levels in patients with stage Ⅳ clear cell renal cancer显示文摘 | FELDMAN A L TAMARKIN L PACIOTH G F | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 16 | Potenlial benefits of delta encoding and data compression for HTTP显示文摘 | Mogul J C Douglis F Feldman A | 1997 | ACM SIGCOMM Computer Communication Review1997，25，4： | 1 |
| 17 | Patellar height on sagittal MR imaging of the knee显示文摘 | Miller TT Staren RB Feldman F | 1996 | AJR1996，167，2： | 1 |
| 18 | Tympanostomy tubes and developmental outcomes at 9 to 11 years of age显示文摘 | Paradise J L Feldman H M Campbell T F | 2007 | N Engl J Med2007，356，3： | 1 |
| 19 | Interplay of matrixmetal Loproteinases, tissue inhibitors of metal loproteinases and the inregulator sincardiac matrixremodeling 显示文摘 | Li YY McTieman C F Feldman AM | 2000 | Cardiovasc Res2000，468，2： | 1 |
| 20 | Meniscal position on routine MR imaging of the knee 显示文摘 | Miller TT Staron RB Feldman F | 1997 | Skeletal Radiol1997，26，： | 1 |
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