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| 1 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 2 | Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans 显示文摘 | Levy-Adam F Feld S Suss-Toby E | 2008 | PLoS ONE2008，3，6： | 1 |
| 3 | Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase Ⅱ study显示文摘 | Hochhaus A Feld E | 2002 | Blood2002，99，： | 1 |
| 4 | Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavifin 显示文摘 | Feld JJ Kowdley KV Coakley E | | N Engl J Med0，370，17： | 1 |
| 5 | A functional role for KLF6- SV1 in lung adenocarcinoma prognosis and chemotherapy response 显示文摘 | DiFeo A Feld L Rodriguez E | 2008 | CancerRes2008，68，4： | 1 |
| 6 | Blood testing to determine overtraining in swimmers显示文摘 | BURKE E R FALSETTI HL FELD R D | 1982 | Swim Tech1982，18，： | 1 |
| 7 | Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin 显示文摘 | Feld JJ Kowdley KV Coaldey E | 2014 | N EnglJ Med2014，370，17： | 1 |
| 8 | Screening dipstick urinalysis: a time to change显示文摘 | Kaplan R E Springate J E Feld L G | 1997 | Pediatrics1997，100，6： | 1 |
| 9 | Endpoints of therapy in chronic hepatitis B 显示文摘 | FELD J J WONG D K HEATHCOTE E J | 2009 | Hepatology2009，49，5： | 1 |
| 10 | Osteoarthritis in the tem poro-m and ibular joint ( TM J) of agedm ice and the in vitro effect of TGF-b eta 1 on cell proliferation, matrix synthesis, and alkaline phosphatase activity显示文摘 | Livne E LauferD B lure en feld I | 1997 | Mierosc Res Tech1997，37，4： | 1 |
| 11 | Nature显示文摘 | Feld M Fr6hlich B Vogt E | 2011 | 480:752011，480，： | 1 |
| 12 | Percutaneous aortic valve replacement for severe aortic stenosis in high-risk patients using the second- and current third-generation self-expanding CoreValve prosthesis: device success and 30-day clinical outcome显示文摘 | Grube E Schuler G Feld L | 2007 | Am Coil Cardiol2007，50，1： | 1 |
| 13 | Using electrocardiographic activation time and diastolic intervals to separate focal from macro-re-entrant atrial tachycardias显示文摘 | Brown J P Krummen D E Feld G K | 2007 | J Am Coll Cardiol2007，49，19： | 1 |
| 14 | Characterization of a small erythromycin resistance plasmid pLFE1 from the food-isolate Lactobacillus plantarumM345 显示文摘 | Feld L Bielak E Hammer K | 2009 | Plasmid2009，61，： | 1 |
| 15 | A functional role for KLF-6-SV1 in lung adenocarcinoma prognosis and chemotherapy response显示文摘 | Difeo A Feld L Rodriguez E | 2008 | Cancer Res2008，68，4： | 1 |
| 16 | Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin显示文摘 | Feld JJ Kowdley KV Coakley E | 2014 | N Engl J Med2014，370，17： | 1 |
| 17 | Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells显示文摘 | Felding Habermnn B Fransvea E O'Toole T E | 2002 | Clin Exp Metastasis2002，19，5： | 1 |
| 18 | Hepatic candidiasis: an increasing problem in immunocompromised patients 显示文摘 | Haron E Feld R Tuffnell P | 1987 | Am J Med1987，83，1： | 1 |
| 19 | The incidence of actinomyces like organisms in Papanicolaou stained smears of copper and levonorgestrel releasing intrauterine devices显示文摘 | Merki Feld G S Lebeda E Hogg B | 2000 | Contraception2000，61，6： | 1 |
| 20 | Treatment of HCV with ABT-d50/r-ombitasvir and dasabuvir with ribavi- tin 显示文摘 | FELD J J KOWDLEY K V COAKLEY E | 2014 | N Engl J Med2014，370，17： | 1 |
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