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| 1 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 2 | Catalytic Growth of Zinc Oxide Nanowires by Vapor Transport显示文摘 | Huang M H Wu Y Feick H | 2001 | Adv Mater(S0935-9648)2001，13，： | 1 |
| 3 | Intracellular localization and in vivo trafficking of p24A and p23显示文摘 | Blum R Pfeiffer F Feick P | | 0，，： | 1 |
| 4 | Room-temperature UltravioletNanowire Nanolasers显示文摘 | Huang M H Mao S Feick H | 2001 | Science2001，292，5523： | 1 |
| 5 | Room-temperature ultraviolet nanowire nanolaser显示文摘 | HUANG M H MAO S FEICK H | 2001 | Science2001，292，： | 1 |
| 6 | Catalytic growth of zinc oxide nanowires by vapor transport显示文摘 | HUANG M H HU Y FEICK H | 2001 | Adv Mater2001，13，： | 1 |
| 7 | Room-temperature Ultraviolet Nanowire Nanolasers 显示文摘 | Huang M H Mao S Feick H et at | 2001 | Science2001，292，5523： | 1 |
| 8 | Room-temperature ultraviolet nanowire nanolasers显示文摘 | Huang M H Mao S Feick H | 2001 | Science2001，292，5523： | 1 |
| 9 | Room-temperature ultraviolet nanowire nanolasers显示文摘 | Huang M H Mao S Feick H Yan H Wu Y Kind H Weber E Russo R Yang P | 2001 | Science2001，292，： | 1 |
| 10 | Room-temperature ultraviolet nanowire nanolasers显示文摘 | HUANG M H MAO S FEICK H | 2001 | Science2001，292，5523： | 1 |
| 11 | Room-Temperature Ultraviolet Nanowire Nanolasers 显示文摘 | Huang H M Mao S Feick H | 2001 | Science2001，292，： | 1 |
| 12 | Responsiveness of intestinal epithelial cell lines to lipopolysaccharide is corre- lated with Toll-like receptor 4 but not Toll-like receptor 2 or CD14 expression 显示文摘 | Bocker U Yezerskyy O Feick P | 2003 | Int J Colorectal Dis2003，18，： | 1 |
| 13 | Room-temperature ultraviolet nanowire nanolasers 显示文摘 | Huang M H Mao S Feick H | 2001 | Science2001，292，5523： | 1 |
| 14 | Room-temperature ultraviolet nanowire nanolasers显示文摘 | Huang M H Mao S Feick H | 2001 | Science2001，292，5523： | 1 |
| 15 | How Males and Females Differ in Their Likelihood of Transmit ting Negative Word of Mouth 显示文摘 | ZHANG Y FEICK L MITTAL V | 2014 | Journal of Con- sumer Research2014，40，6： | 1 |
| 16 | Luminescence energy and carrier lifetime in inGaN/GaN quantum wells as a function of applied biaxial strain显示文摘 | Shapiro N A Feick H Hong W | 2003 | J Appl Phys2003，94，7： | 1 |
| 17 | Room-Temperature Ultravolet Nanowire Nanolasers 显示文摘 | Huang M H Mao S Feick H | 2001 | Science2001，292，： | 1 |
| 18 | Room-temperatureultraviolet nanowire nanolasers显示文摘 | HUANG M H MAO S FEICK H | 2001 | Science2001，292，5523： | 1 |
| 19 | An adipogenic serum factor in genetically obese rodents显示文摘 | LOFFLER G FEICK G HAUNER H HERBERG L | 1983 | FEBS Lett1983，153，： | 1 |
| 20 | Room-Temperature Ultraviolet Nanowire Nanolasers显示文摘 | Huang H M Mao S Feick H | 2001 | Science2001，292，： | 1 |
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