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1Increased resistance of drought by Trichoderma harzianum fungal treatment correlates with increased secondary metabolites and proline content显示文摘Plant secondary metabolites play vital role in plant stress response. In this study we investigated whether root colonization of tomato(Solanum lycopersicum) infected by Trichoderma harzianum leads to alterations in the biosynthesis of secondary plant metabolites including phytohormones and osmolyte proline under drought stress. Exposure of tomato to drought caused a drastic decline in plant growth and physiological parameters. Tomato inoculated with T. harzianum showed increased root and shoot growth and chlorophyll pigments as compared to uninoculated controls as well as drought stressed plants. Proline and total soluble protein content was increased in plants inoculated with T. harzianum under both normal as well as drought conditions. An obvious increase in phenol and flavonoid content was observed due to T. harzianum. In addition, T. harzianum inoculated plants maintained higher levels of growth regulators indole acetic acid, indole butyric acid, and gibberellic acid under drought stress. Improved secondary metabolites which play an important role in plant stress tolerance by T. harzianum may have coordinately worked for bringing the growth regulation by protecting membranes from reactive oxygen species(ROS) and enhance plant growth through accessing more nutrients by root system.Mona S.Alwhibi Abeer Hashem Elsayed Fathi Abd_Allah Abdulaziz A.Alqarawi Dina Wafi K.Soliman Stephan Wirth Dilfuza Egamberdieva 2017Journal of Integrative Agriculture2017,16,8:15
2Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases显示文摘AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary tumors.METHODS This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the periods.CONCLUSION Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%.ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab 2017World Journal of Gastroenterology2017,23,38:15
3Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis显示文摘AIM:To evaluate effective alternative antibiotics in treatment of cefotaxime-resistant spontaneous bacterial peritonitis.METHODS:One hundred cirrhotic patients with spontaneous bacterial peritonitis [ascitic fluid polymorphonuclear cell count(PMNLs) ≥ 250 cells/mm 3 at admission] were empirically treated with cefotaxime sodium 2 g/12 h and volume expansion by intravenous human albumin.All patients were subjected to history taking,complete examination,laboratory tests(including a complete blood cell count,prothrombin time,biochemical tests of liver and kidney function,and fresh urine sediment),chest X-ray,a diagnostic abdominal paracentesis,and the sample subjected to total and differential cell count,chemical examination,aerobic and anaerobic cultures.Patients were divided after 2 d by a second ascitic PMNL count into group Ⅰ;patients sensitive to cefotaxime(n = 81),group Ⅱ(n = 19);cases resistant to cefotaxime(less than 25% decrease in ascitic PMNL count).Patients of group Ⅱ were randomly assigned into meropenem(n = 11) or levofloxacin(n = 8) subgroups.All patients performed an end of treatment ascitic PMNL count.Patients were considered improved when:PMNLs decreased to < 250 cells/mm 3,no growth in previously positive culture cases,and improved clinical manifestations with at least 5 d of antibiotic therapy.RESULTS:Age,sex,and Child classes showed no significant difference between group Ⅰ and group Ⅱ.Fever and abdominal pain were the most frequent manifestations and were reported in 82.7% and 80.2% of patients in group Ⅰ and in 94.7% and 84.2% of patients in group Ⅱ,respectively.Patients in group Ⅱ had a more severe ascitic inflammatory response than group Ⅰ and this was demonstrated by more ascitic lactate dehydrogenase(LDH) [median:540 IU/L(range:150-1200 IU/L) vs median:240 IU/L(range:180-500 IU/L),P = 0.000] and PMNL [median:15 000 cell/mm 3(range:957-23 822 cell/mm 3) vs 3400 cell/mm 3(range:695-26 400 cell/mm 3),P = 0.000] counts.Ascitic fluid culture was positive in 32% of cases.Cefotaxime failed in 19% of patients;of these patients,11(100%) responded to meropenem and 6(75%) responded to levofloxacin.Two patients with failed levofloxacin therapy were treated according to the in vitro culture and sensitivity(one case was treated with vancomycin and one case was treated with ampicillin/sulbactam).In group Ⅱ the meropenem subgroup had higher LDH(range:108-860 IU/L vs 120-491 IU/L,P = 0.042) and PMNL counts(range:957-23 822 cell/mm 3 vs 957-15 222 cell/mm 3,P = 0.000) at initiation of the alternative antibiotic therapy;there was no significant difference in the studied parameters between patients responsive to meropenem and patients responsive to levofloxacin at the end of therapy(mean ± SD:316.01 ± 104.03PMNLs/mm 3 vs 265.63 ± 69.61 PMNLs/mm 3,P = 0.307).The isolated organisms found in group Ⅱ were;enterococci,acinetobacter,expanded-spectrum β-lactamase producing Escherichia coli,β-lactamase producing Enterobacter and Staphylococcus aureus.CONCLUSION:Empirical treatment with cefotaxime is effective in 81% of cases;meropenem is effective in cefotaxime-resistant cases.Ahmed Abouelkhair Badawy Tarik Ibrahim Zaher Samar Mahmoud Sharaf Mohamed Hassan Emara Noha Elsaid Shaheen Talaat Fathy Aly 2013World Journal of Gastroenterology2013,19,8:13
4Human embryonic stem cell-derived mesenchymal stem cells improved premature ovarian failure显示文摘BACKGROUND Premature ovarian failure(POF)affects many adult women less than 40 years of age and leads to infertility.According to previous reports,various tissue-specific stem cells can restore ovarian function and folliculogenesis in mice with chemotherapy-induced POF.Human embryonic stem cells(ES)provide an alternative source for mesenchymal stem cells(MSCs)because of their similarities in phenotype and immunomodulatory and anti-inflammatory characteristics.Embryonic stem cell-derived mesenchymal stem cells(ES-MSCs)are attractive candidates for regenerative medicine because of their high proliferation and lack of barriers for harvesting tissue-specific MSCs.However,possible therapeutic effects and underlying mechanisms of transplanted ES-MSCs on cyclophosphamide and busulfan-induced mouse ovarian damage have not been evaluated.AIM To evaluate ES-MSCs vs bone marrow-derived mesenchymal stem cells(BMMSCs)in restoring ovarian function in a mouse model of chemotherapy-induced premature ovarian failure.METHODS Female mice received intraperitoneal injections of different doses of cyclophosphamide and busulfan to induce POF.Either human ES-MSCs or BMMSCs were transplanted into these mice.Ten days after the mice were injected with cyclophosphamide and busulfan and 4 wk after transplantation of the ESMSCs and/or BM-MSCs,we evaluated body weight,estrous cyclicity,folliclestimulating hormone and estradiol hormone concentrations and follicle count were used to evaluate the POF model and cell transplantation.Moreover,terminal deoxynucleotidyl transferase mediated 2-deoxyuridine 5-triphosphate nick end labeling,real-time PCR,Western blot analysis and immunohistochemistry and mating was used to evaluate cell transplantation.Enzyme-linked immunosorbent assay was used to analyze vascular endothelial growth factor,insulin-like growth factor 2 and hepatocyte growth factor levels in ES-MSC condition medium in order to investigate the mechanisms that underlie their function.RESULTS The human ES-MSCs significantly restored hormone secretion,survival rate and reproductive function in POF mice,which was similar to the results obtained with BM-MSCs.Gene expression analysis and the terminal deoxynucleotidyl transferase mediated 2-deoxyuridine 5-triphosphate nick end labeling assay results indicated that the ES-MSCs and/or BM-MSCs reduced apoptosis in the follicles.Notably,the transplanted mice generated new offspring.The results of different analyses showed increases in antiapoptotic and trophic proteins and genes.CONCLUSION These results suggested that transplantation of human ES-MSCs were similar to BM-MSCs in that they could restore the structure of the injured ovarian tissue and its function in chemotherapy-induced damaged POF mice and rescue fertility.The possible mechanisms of human ES-MSC were related to promotion of follicular development,ovarian secretion,fertility via a paracrine effect and ovarian cell survival.Khadijeh Bahrehbar Mojtaba Rezazadeh Valojerdi Fereshteh Esfandiari Rouhollah Fathi Seyedeh-NafisehHassani Hossein Baharvand 2020World Journal of Stem Cells2020,12,8:12
5Review of tumoral calcinosis: A rare clinico-pathological entity显示文摘Tumoral calcinosis(TC) has long been a controversial clinico-pathological entity. Its pathogenesis and genetic background have been gradually unravelled since its first description in 1943. According to the presence or absence of an underlying calcifying disease process, TC has been divided into primary and secondary varieties. Two subtypes of the primary variety exist; a hyperphosphatemic type with familial basis represented by mutations in Gal NAc transferase 3 gene(GALNT3), KLOTHO or Fibroblast growth factor 23(FGF23) genes, and a normo-phosphatemic type with growing evidence of underlying familial base represented by mutation in SAMD9 gene. The secondary variety is mainly associated with chronic renal failure and the resulting secondary or tertiary hyperparathyroidism. Diagnosis of TC relies on typical radiographic features(on plain radiographs and computed tomography) and the biochemical profile. Magnetic resonance imaging can be done in difficult cases, and scintigraphy reflects the disease activity. Treatment is mainly surgical for the primary variety; however, a stage-oriented conservative approach using phosphate binders, phosphate restricted dietsand acetazolamide should be considered before the surgical approach is pursued due to the high rate of recurrences and complications after surgical intervention. Medical treatment is the mainstay for treatment of the secondary variety, with failure warranting subtotal or total parathyroidectomy. Surgical intervention in these patients should be kept as a last resort.Ibrahim Fathi Mahmoud Sakr 2014World Journal of Clinical Cases2014,2,9:11
6Ultrasound-guided transrectal extended prostate biopsy:a prospective study显示文摘Aim: To evaluate the diagnostic value of the 10 systematic transrectal ultrasound-guided (TRUS) prostate biopsy compared with the sextant biopsy technique for patients with suspected prostate cancer. Methods: One hundred and fifty-two patients with suspected prostate cancer were included in the study. Patients were entered in the study because they presented with high levels of prostate specific antigen (PSA) (over 4ng/mL) and/or had undergone an abnormal digital rectal examination (DRE). In addition to sextant prostate biopsy cores, four more biopsies were obtained from the lateral peripheral zone with additional cores from each suspicious area revealed by transrectal ultrasound. Sextant, lateral peripheral zone and suspicious area biopsy cores were submitted separately to the pathological department. Results: Cancer detection rates were 27.6%(42/152) and 19.7%(30/152) for the 10-core and sextant core biopsy protocols, respectively. Adding the lateral peripheral zone (PZ) to the sextant prostate biopsy showed a 28.6%(12/42) increase in the cancer detection rate in patients with positive prostate cancer (P<0.01).The cancer detection rate in patients who presented with elevated PSA was 29.3%(34/116). When serum PSA was 4-10ng/mL TRUS-guided biopsy detected cancer in 20.6%, while the detection rate was 32.4% and 47.0% when serum PSA was 10-20ng/mL and above 20ng/mL, respectively. Conclusion: The 10 systematic TRUS-guided prostate biopsy improves the detection rate of prostate cancer by 28.6% when compared with the sextant biopsy technique alone, without increase in the morbidity. We therefore recommend the 10-core biopsy protocol to be the preferred method for early detection of prostate cancer.Mohammed Ahmed Al-Ghazo Ibrahim Fathi Ghalayini Ismail Ibrahim Matalka 2005Asian Journal of Andrology2005,7,2:10
7Turbine blade temperature calculation and life estimation-a sensitivity analysis显示文摘The overall operating cost of the modern gas turbines is greatly influenced by thedurability of hot section components operating at high temperatures.In turbine operatingconditions,some defects may occur which can decrease hot section life.In the present paper,methods used for calculating blade temperature and life are demonstrated and validated.Usingthese methods,a set of sensitivity analyses on the parameters affecting temperature and life ofa high pressure,high temperature turbine first stage blade is carried out.Investigateduncertainties are:(1)blade coating thickness,(2)coolant inlet pressure and temperature(asa result of secondary air system),and(3)gas turbine load variation.Results show thatincreasing thermal bamier coating thickness by 3 times,leads to rise in the blade life by 9times.In addition,considering inlet cooling temperature and pressure,deviation in temperaturehas greater effect on blade life.One of the interesting points that can be realized from theresults is that 300 hours operation at 70%load can be equal to one hour operation atbase load.Majid Rezazadeh Reyhani Mohammad Alizadeh Alireza Fathi Hiwa Khaledid 2013Propulsion and Power Research2013,2,2:9
8Mg(OH)_2 Nanorods Synthesized by A Facile Hydrothermal Method in the Presence of CTAB显示文摘Magnesium hydroxide(Mg(OH)_2) nanorods were synthesized by a simple and facile hydrothermal method in the presence of cetyltetramethylammonium bromide(CTAB) as a surfactant. Nanorods of magnesium oxide Mg O were also induced by thermal decomposition of Mg(OH)_2 nanorods at 700. By using disk diffusion technique, the Mg(OH)_2 nanorods were found to exhibit higher antibacterial efficiency against several tested bacterial strains.Hassouna Dhaouadi Hedia Chaabane Fathi Touati 2011Nano-Micro Letters2011,3,3:9
9在线学习的理论与实践显示文摘本刊今年第3期刊登了记者对国际知名远程教育专家、加拿大阿萨巴斯卡大学特里·安德森教授的专访。安德森教授在专访中提及他和同事法希·埃劳米的新著《在线学习的理论与实践》,“希望能得到我们中国朋友的青睐和欣赏”。该书收录了16篇论文,作者全部是阿萨巴斯卡大学的教师和研究者,也都是20世纪90年代中期以来阿萨巴斯卡大学为了应对日益裁减的政府资助和生源的锐减而进行大规模教育改革的实践者和见证人,这些论文既有经验总结又有前瞻性的思考,对我国的远程教育事业不无借鉴价值。鉴于此,本刊特邀肖俊洪先生谨将该书两位主编所撰写的“引言”中的有关全书内容概要的部分译成中文,以飨读者。Terry Anderson Fathi Elloumi 肖俊洪 2004开放教育研究2004,10,5:8
10Pathological,immunohistochemical and microbiologicalal analysis of lacrimal sac biopsies in patients with chronic dacrocystitis显示文摘AIM:To analyze cases of obstruction of the nasolacrimal duct which creates a fertile environment for secondary bacterial Infection and can result in dacryocystitis,which is a constant threat to cornea and orbital soft tissue and a potential source of endophthalmitis following intraocular surgery.The majority of obstructions of the lacrimal excretory outflow system are acquired ones occurring in adulthood and involving the distal parts of the system.Acquired obstruction may be primary/idiopathic or secondary to a wide variety of infectious,inflammatory,traumatic,mechanical,toxic or neoplastic causes mimicking idiopathic inflammation.These cases are treated by dacryocystorhinostomy(DCR).METHODS:The present study was conducted to determine the histopathologic,immunohistochemical and current microbiologic characteristics of lacrimal sac specimens in patients undergoing external dacryocystorhinostomy.RESULTS:Non-specific lacrimal sac pathology was present in all 33 cases and 81.8%of the cases showed moderate chronic inflammation with a chronic inflammatory score(CIS)ranging between 4 and 6,whereas 12.12%showed severe inflammatory changes with a CIS of 7.Mild degree of inflammation was seen in6.06%with a CIS of 3.The total prevalence of grampositive,gram-negative,and culture-negative samples were 59.4%,37.5%,and 3%respectively.CONCLUSION:Non-specific chronic inflammation withfibrosis is indeed the most commonly reported histopathological finding in lacrimal sac wall biopsy specimens.Rowayda Mahmoud Amin Faten Aly Hussein Hisham Farouk Idriss Nesrine Fathy Hanafy Dina Mohamed Abdallah 2013International Journal of Ophthalmology(English edition)2013,6,6:7
11Noninvasive hemodynamic monitoring of septic shock in children显示文摘Septic shock in children is associated with high mortality and morbidity. Its management is time-sensitive and must be aggressive and target oriented. The use of clinical assessment alone to differentiate between cold and warm shock and to select the appropriate inotropic and vasoactive medications is fraught with errors. Semiquantitative and quantitative assessment of the preload,contractility and afterload using non-invasive tools has been suggested,in conjunction with clinical and laboratory assessment,to direct shock management and select between vasopressors,vasodilators and inotropes or a combination of these drugs. This review aims to describe non-invasive tools to assess the hemodynamic status in septic shock including echocardiography,trans-thoracic/trans-esophageal Doppler and electrical cardiometry. As septic shock is a dynamic condition that changes markedly overtime,frequent or continuous measurement of the cardiac output(CO),systemic vascular resistance(SVR) and other hemodynamic parameters using the above-mentioned tools is essential to personalize the treatment and adapt it over time. The different combinations of blood pressure,CO and SVR serve as a pathophysiological framework to manage fl-uid therapy and titrate inotropic and vasoactive drugs. Near infrared spectroscopy is introduced as a noninvasive method to measure end organ perfusion and assess the response to treatment.Emad Mohamed Fathi Hassib Narchi Fares Chedid 2018World Journal of Methodology2018,8,1:7
12An Intelligent Harmonic Synthesis Technique for Air-Gap Eccentricity Fault Diagnosis in Induction Motors显示文摘Induction motors(IMs) are commonly used in various industrial applications. To improve energy consumption efficiency, a reliable IM health condition monitoring system is very useful to detect IM fault at its earliest stage to prevent operation degradation, and malfunction of IMs. An intelligent harmonic synthesis technique is proposed in this work to conduct incipient air-gap eccentricity fault detection in IMs. The fault harmonic series are synthesized to enhance fault features. Fault related local spectra are processed to derive fault indicators for IM airgap eccentricity diagnosis. The effectiveness of the proposed harmonic synthesis technique is examined experimentally by IMs with static air-gap eccentricity and dynamic air-gap eccentricity states under different load conditions. Test results show that the developed harmonic synthesis technique can extract fault features effectively for initial IM air-gap eccentricity fault detection.De Z.Li Wilson Wang Fathy Ismail 2017Chinese Journal of Mechanical Engineering2017,30,6:7
13Stem cell therapy for nerve injury显示文摘Peripheral nerve injury has remained a substantial clinical complication with no satisfactory treatment options.Despite the great development in the field ofmicrosurgery,some severe types of neural injuries cannot be treated without causing tension to the injured nerve.Thus current studies have focused on the new approaches for the treatment of peripheral nerve injuries.Stem cells with the ability to differentiate into a variety of cell types have brought a new perspective to this matter.In this review,we will discuss the use of three main sources of mesenchymal stem cells in the treatment of peripheral nerve injuries.Sara Sayad Fathi Arash Zaminy 2017World Journal of Stem Cells2017,9,9:7
14Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients显示文摘AIM: To investigate the association of the functional monocyte chemotactic protein-1(MCP-1) promoter polymorphism(A-2518G) with spontaneous bacterial peritonitis(SBP).METHODS: Fifty patients with post-hepatitis C liver cirrhosis and ascites were categorized into two groups; group Ⅰ included 25 patients with SBP and group Ⅱ included 25 patients free from SBP. In addition, a group of 20 healthy volunteers were included. We assessed the MCP-1 gene polymorphism and gene expression as well as interleukin(IL)-10 levels in both blood and ascitic fluid. RESULTS: A significant MCP-1 gene polymorphism was detected in groups Ⅰ and Ⅱ(P = 0.001 and 0.02 respectively). Group Ⅰ was associated with a significantly higher frequency of AG genotype [control 8(40%) vs SBP 19(76.0%), P < 0.001], and group Ⅱ was associated with a significantly higher frequency of GG genotype when compared to healthy volunteers [control 1(5%) vs cirrhotic 16(64%), P < 0.001]. Accordingly, the frequency of G allele was significantly higher in both groups(Ⅰ and Ⅱ) [control 10(25%) vs SBP 27(54%), P < 0.001 and vs cirrhotic 37(74.0%), P < 0.001, respectively]. The total blood and ascetic fluid levels of IL-10 and MCP-1 gene expression were significantly higher in group Ⅰ than in group Ⅱ. Group Ⅰ showed significant reductions in the levels of MCP-1 gene expression and IL-10 in the whole blood and ascetic fluid after therapy. CONCLUSION: MCP-1 GG genotype and G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may increase the susceptibility to SBP. Patients carrying these genotypes should be under supervision to prevent or restrict further complications.Maysa Kamal Salama Dina Sabry Mohamed AS Al-Ghussein Rasha Ahmed Sayed AbdAllah Fatma Mohamed Taha Wael Fathy Miriam Safwat Wadie Mona Nabih Amr Abul-Fotouh Tarneem Darwish 2014World Journal of Gastroenterology2014,20,33:7
15基于瞬时产量递减分析确定天然裂缝性油藏平均地层压力显示文摘以Warren和Root等提出的裂缝-孔隙双重介质模型为基础,拓展延伸了Mavor、Cinco-Ley和Daprat等的裂缝系统拟稳态-定产量生产的解及基质系统拟稳态-定压力生产的解,提出了根据天然裂缝性油藏定压开采的瞬时产量递减准确估算油藏平均压力的新方法。具体方法为:分别将基质产量方程和裂缝产量方程两端取自然对数,得到两条直线;再利用其斜率和截距确定弹性储容比、油藏总储容以及泄油面积,最后确定平均地层压力。经算例和实例验证,新方法简单实用,与物质平衡法和Tiab直接合成技术法得到的估算结果十分接近。Daryasafar Amin Amareh Iman Fathi Nasab Mohammad Kharrat Riyaz Jalilian Milad 2015石油勘探与开发2015,42,2:5
16Properties of Steel Slag and Stainless Steel Slag as Cement Replacement Materials:A Comparative Study显示文摘To enhance the understanding about the utilization of steel slags as a cementitious material, we comparatively studied the chemical, mineralogical and morphological properties of two types of steel slag; basicoxygen-furnace carbon slag(BOF C) and electric-arc-furnace stainless steel slag(EAF S). Moreover, we studied the standard consistency, setting time and the effect of the slag replacement ratios on the fluidity and compressive strength of blended cement mortar. The experimental results showed that BOF C had higher alkalinity, higher pH value and more hydraulic phases than EAF S. Both types of slag showed water reduction effect due to its high fineness. Neat BOF C paste showed flash set and acceleration in the initial setting time of blended cement especially at high slag proportions. However, EAF S prolonged the setting time of blended cement even at low slag proportions. The pH values for blended cement contained 50% BOF C or EAF S were lower than those of pure cement paste. Despite of slag type, compressive strength gradually decreased with increasing slags content. The strength of BOF C mortar was higher than that of EAF S mortar with the same replacement ratio for the same age. Slag activity index demonstrated that BOF C and EAF S conformed to the Chinese National Standard(GB/T 20491-2006) requirements for steel slag as grade one and grade two, respectively.SALY Fathy GUO Liping MA Rui GU Chunping SUN Wei 2018Journal of Wuhan University of Technology(Materials Science)2018,33,6:5
17Hepatitis-related hepatocellular carcinoma: Insights into cytokine gene polymorphisms显示文摘Hepatocellular carcinoma(HCC) is a primary liver cancer, which is one of the most prevalent cancers among humans. Many factors are involved in the liver carcinogenesis as lifestyle and environmental factors. Hepatitis virus infections are now recognized as the chief etiology of HCC; however, the precise mechanism is still enigmatic till now. The inflammation triggered by the cytokine-mediated immune response, was reported to be the closest factor of HCC development. Cytokines are immunoregulatory proteins produced by immune cells, functioning as orchestrators of the immune response. Genes of cytokines and their receptors are known to be polymorphic, which give rise to variations in their genes. These variations have a great impact on the expression levels of the secreted cytokines. Therefore, cytokine gene polymorphisms are involved in the molecular mechanisms of several diseases. This piece of work aims to shed much light on the role of cytokine gene polymorphisms as genetic host factor in hepatitis related HCC.Mahmoud Fathy Dondeti Eman Anwar El-Maadawy Roba Mohamed Talaat 2016World Journal of Gastroenterology2016,22,30:4
18Fair subcarrier-power allocation scheme for multiuser multicarrier systems显示文摘The main objective of multiuser orthogonal frequency division multiple access(MU-OFDM) is to maximize the total system capacity in wireless communication systems. Thus, the problem in MU-OFDM system is the adaptive allocation of the resources(subcarriers, bits and power) to different users subject to several restrictions to maximize the total system capacity. In this work, a proposed subcarrier allocation algorithm was presented to assign the subcarriers with highest channel gain to the users. After the subcarrier allocation, subcarrier gain-based power allocation(SGPA) was employed for power and bit loading. The simulation results show that the proposed subcarrier-power allocation scheme can achieve high total system capacity and good fairness in allocating the resources to the users with slightly high computational complexity compared to the existing subcarrier allocation algorithms.Mohammed Abd-Elnaby Germien G.Sedhom Nagy W.Messiha Xu Zhu Fathi E.Abd El-Samie 2015Journal of Central South University2015,22,8:4
19Effects of variable properties on MHD heat and mass transfer flow near a stagnation point towards a stretching sheet in a porous medium with thermal radiation显示文摘The effect of variable viscosity and thermal conductivity on steady magnetohydrodynamic(MHD) heat and mass transfer flow of viscous and incompressible fluid near a stagnation point towards a permeable stretching sheet embedded in a porous medium are presented,taking into account thermal radiation and internal heat genberation/absorbtion.The stretching velocity and the ambient fluid velocity are assumed to vary linearly with the distance from the stagnation point.The Rosseland approximation is used to describe the radiative heat flux in the energy equation.The governing fundamental equations are first transformed into a system of ordinary differential equations using a scaling group of transformations and are solved numerically by using the fourth-order Rung-Kutta method with the shooting technique.A comparison with previously published work has been carried out and the results are found to be in good agreement.The results are analyzed for the effect of different physical parameters,such as the variable viscosity and thermal conductivity,the ratio of free stream velocity to stretching velocity,the magnetic field,the porosity,the radiation and suction/injection on the flow,and the heat and mass transfer characteristics.The results indicate that the inclusion of variable viscosity and thermal conductivity into the fluids of light and medium molecular weight is able to change the boundary-layer behavior for all values of the velocity ratio parameter λ except for λ = 1.In addition,the imposition of fluid suction increases both the rate of heat and mass transfer,whereas fluid injection shows the opposite effect.A.M.Salem Rania Fathy 2012Chinese Physics B2012,21,5:4
20Performance of beacon safety message dissemination in Vehicular Ad hoc NETworks (VANETs)显示文摘Currently, there is a growing belief that putting an IEEE 802.11-like radio into road vehicles can help the drivers to travel more safely. Message dissemination protocols are primordial for safety vehicular applications. There are two types of safety messages which may be exchanged between vehicles: alarm and beacon. In this paper we investigate the feasibility of deploying safety applications based on beacon message dissemination through extensive simulation study and pay special attention to the safety requirements. Vehicles are supposed to issue these messages periodically to announce to other vehicles their current situation and use received messages for preventing possible unsafe situations. We evaluate the performance of a single-hop dissemination protocol while taking into account the quality of service (QoS) metrics like delivery rate and delay. We realize that reliability is the main concern in beacon message dissemination. Thus, a new metric named effective range is defined which gives us more accurate facility for evaluating QoS in safety applications specifically. Then, in order to improve the performance, the effects of three parameters including vehicle's transmission range, message transmission's interval time and message payload size are studied. Due to special characteristics of the safety applications, we model the relationship between communication-level QoS and application-level QoS and evaluate them for different classes of safety applications. As a conclusion, the current technology of IEEE 802.11 MAC layer has still some challenges for automatic safety applications but it can provide acceptable QoS to driver assistance safety applications.YOUSEFI Saleh FATHY Mahmood BENSLIMANE Abderrahim 2007Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007,8,12:4
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