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| 1 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016，13，3： | 12 |
| 2 | Multitaper spectral method to estimate the elastic thickness of South China: Implications for intracontinental deformation显示文摘The effective elastic thickness(Te) represents the thickness of the elastic layer or the flexural rigidity of the lithosphere, the equivalent of which can be calculated from the spectral analysis of gravity and topographic data. Studies of Te have profound influence on intracontinental deformation, and coupling of the tectonic blocks. In this paper, we use the multitaper spectral estimation method to calculate the coherence between Bouguer gravity and topography data, and to obtain the Te map of South China.Through the process of correction, we discuss the relationships of Te versus heat flow, and Te versus seismicity. The results show that Te distribution of South China is affected by three factors: the original age, which controls the basic feature; the Mesozoic evolution, which affects the Te distribution; and the neotectonic movement, which shaped the final distribution. The crust age has a positive correlation with the first-order Te distribution; thus the Yangtze Craton has a relatively higher Te(about 50 km) whereas the Te in Cathaysia block is only 10-20 km. By analysis and comparison among the tectonic models of South China, the Te distribution can be well explained using the flat-subduction model. As is typical with neotectonics, the region with a higher heat flow is related with a lower Te. The seismicity does not have a clear relationship with Te, but the strong seismicity could cause a low Te. Seismogenic layer(Ts) has a similar trend as Te in the craton, whereas in other areas the relationship is complex. | Yangfan Deng Zhongjie Zhang Weiming Fan Marta Pérez-Gussinyé | 2014 | Geoscience Frontiers2014，5，2： | 7 |
| 3 | Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice显示文摘为在急性冠的症候群(交流) 和经皮的冠的干预(一种总线标准) 以后的口头的 anticoagulation (OAC ) 上的病人的 ObjectiveThe 最佳的 antithrombotic 政体仍然保持辩论。寻求回顾地在真实世界的 setting.MethodsWe 评估 OAC 正 clopidogrel 的功效和安全与或没有阿司匹林的这研究分析了数据从一国际,在 2003 和 2014 之间的多中心登记(n = 15,401 ) 。有在一种总线标准以后的交流和收到的 OAC 的病人被屏蔽。合成主要端点是 1 年的所有原因死亡,重新梗塞,或分析注册了 642 个病人包括的严重 bleeding.ResultsThe 期末考试有 OAC 和 clopidogrel (双治疗) 的 62 个病人(9.7%) ,和有阿司匹林, OAC 和 clopidogrel (三倍的治疗) 的联合的 580 个病人(90.3%) 。三倍的治疗上的病人更经常是女性的并且是更可能的有 comorbidities。关于在与三倍的治疗病人一起的双治疗之间的主要结束点没有重要差别[17.74% 对 17.24% ;unadjusted 危险比率(HR ) :1.035;95% 信心间隔(CI ) :0.556-1.929;调整 HR:1.026;95% CI:0.544-1.937 ] 。然而,重新梗塞率比三倍的治疗病人在双治疗是显著地更高的(14.52% 对 5.34% ;unadjusted HR:2.807;95% CI:1.329-5.928;调整 HR:2.333;95% CI:1.078-5.047 ) 。另外,在所有原因死亡和严重 bleeding.ConclusionsIn 的二政体之间没有差别有交流后面的一种总线标准并且与 OAC 的一个指示的真实病人,三倍的治疗没与双治疗相比与不利结果的增加的率被联系。而且,它减少了重新梗塞冒险并且没增加严重流血的风险。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE SerGio Raooseiras-Roubin Emad Abu-Assi Jose P Simao Henriques: Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzalez-Juanate Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Morettil Zenon Huczek Toshiharu Fujii Luis cL Correia Masa-aki Kawashiri Sasko Kedev | 2017 | Journal of Geriatric Cardiology2017，14，11： | 6 |
| 4 | Intermediate-acidic silicate melt found in continental mantle of East China显示文摘CO2-RICH fluid inclusions have been found in 6 anhydrous peridotite xenolith minerals in Ceno-zoic basalts of 5 areas in East China.Electron probe backscattering electron image reveals thatseveral inclusions appear in all the rock sections,completely filled with glass or with cavities attheir center part(CO2 has escaped).Some inclusions show devitrification and daughter miner-als appear.We have carried out the analysis on the non-devitrification glass in the inclusions. | Fan, QC Liu, RX Xu, P Lin, ZR | 1997 | Chinese Science Bulletin1997，42，10： | 6 |
| 5 | The transmembrane domain of TACE regulates protein ectodomain shedding显示文摘众多的膜蛋白质被变换酶的肿瘤坏死 factor-alpha 劈开(不作声) ,它引起他们的 ectodomains 的版本。ADAM (一个 disintegrin 和 metalloprotease 领域) 家庭成员,不作声包含谁的几个非催化的领域在流的 ectodomain 的角色还得充分被解决。这里,我们探索了 transmembrane 领域(TM ) 的功能由联合分子的工程和功能的分析不作声。一 TM 免费不作声被有约束力的多肽没能恢复转变生长 factor-alpha (TGF-alpha ) 流的 glycosylphosphatidylinositol (GPI ) 抛锚到血浆膜的构造,肿瘤坏死 factor-alpha (TNF-alpha ) 和在细胞缺乏的 L-selectin 内长不作声活动。有催乳激素受体或导出血小板的生长因素受体(PDGFR ) 的 TACE TM 的替换也导致了流的 TGF-alpha 的严重损失,但是没在 TNF-alpha 和 L-selectin 的劈开上有效果。在有 L-selectin 的 TGF-alpha 的 TM 的代替启用了由带催乳激素受体和 PDGFR 的 TM 的 TACE 异种流的 TGF-alpha。总起来说,我们的观察建议那个抛锚通过 TM 不作声到类脂化合物双性人层为许多底层的有效劈开被要求,并且氨基酸的顺序不作声 TM 可以在规章的特性起一个作用在之中不作声底层。 | Xiaojin Li Liliana Pére Zui Pan Huizhou Fan | 2007 | Cell Research2007，17，12： | 5 |
| 6 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 7 | Are hyoliths Palaeozoic lophophorates?显示文摘The phylogenetic position of hyoliths has long been unsettled,with recent discoveries of a tentaculate feeding apparatus('lophophore')and fleshy apical extensions from the shell('pedicle')suggesting a lophophorate affinity.Here,we describe the first soft parts associated with the feeding apparatus of an orthothecid hyolith,Triplicatella opimus from the Chengjiang biota of South China.The tuft-like arrangement of the tentacles of T.opimus differs from that of hyolithids:suggesting they collected food directly from the substrate.A reassessment of the feeding organ in hyolithids indicates that it does not represent a lophophore and our analysis of the apical structures associated with some orthothecids show that these represent crushed portions of the shell and are not comparable to the brachiopod pedicle.The new information suggests that hyoliths are more likely to be basal members of the lophotrochozoans rather than lophophorates closely linked with the Phylum Brachiopoda. | Fan Liu Christian B Skovsted Timothy P Topper Zhifei Zhang Degan Shu | 2020 | National Science Review2020，7，2： | 5 |
| 8 | Design, Synthesis and Biological Evaluation of Isothiazole Based 1,2,4-Trizaole Derivatives显示文摘 | Lai Chen Qifan Wu Zhijin Fan Hongpeng Li Jiwei Li Wenhao Hu Xiumei Liu Nataliya P Belskaya Tatiana Glukhareva Bin Zhao | 2018 | Chinese Journal of Chemistry2018，36，8： | 2 |
| 9 | Keap1-Nrf2-ARE和p53/p21信号通路在对乙酰氨基酚引起肝损伤后肝再生中的作用显示文摘对乙酰氨基酚(acetaminophen,APAP)过量使用是引起肝损伤的主要原因。代偿性肝再生是药物性肝损伤的关键因素。但是APAP引起的肝损伤后肝再生的分子机制尚不清楚。本文旨在讨论Keapl—Nrf2-ARE和p53/p21信号通路在APAP引起肝损伤后肝再生中的作用。研究人员通过给予小鼠400mg/kg的APAP体内注射后发现,小鼠在12h内表现出巨大的肝毒性,而肝脏功能的恢复却要在24h之后。 | Fan X Chen P Tan H 牛强 | 2014 | 中华损伤与修复杂志(电子版)2014，9，5： | 2 |
| 10 | Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro 显示文摘 | Fan J M Ng Y Y Hill P A | 1999 | Kidney Int1999，56，4： | 2 |
| 11 | Disentangling the Incentive and Entrenchment Effects of Large Shareholders显示文摘 | Claessens s Djankov S Joseph P H Fan Larry H P Lang | 2002 | Journal of Finance2002，57，： | 1 |
| 12 | QoS-aware Web service configuration显示文摘 | XIONG P FAN Y ZHOU M | 2008 | IEEE Trans on Systems Man and Cybernetics2008，38，4： | 1 |
| 13 | Microcavities in Photonic Crystals: Mode Symmetry, Tenability, and Coupling Efficiency显示文摘 | VILLENEUVE P R FAN S JOANNOPOULOS J D | 1996 | Phys Rev B1996，54，11： | 1 |
| 14 | Completion of the primary structure of the human type Ⅳ collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16显示文摘 | EDDY RL FAN YS | 1990 | Genomics1990，6，： | 1 |
| 15 | Preparation,characterization and antimicrobial activity of quaternized carboxymethyl chitosan and application as pulp-cap显示文摘 | SUN L P DU Y M FAN L H | 2006 | Polymer2006，47，6： | 1 |
| 16 | Disentangling the Incentive and entrenchment effects of large Shareholdings 显示文摘 | Claessens S Djankov S FAN J Lang L H P | 2002 | Journal of Finance2002，57，6： | 1 |
| 17 | Geochemical characteristics of oils from Qaidam,Shanganning and Jianghan basins,China显示文摘 | PHILP R P FAN P LEWIS C A | 1991 | Journal of Southeast Asian Earth Sciences1991，5，3： | 1 |
| 18 | The Influence of the Temperature of Calcination on the Surface Fractal Dimensions of Ca(OH)2-derived Sorbents显示文摘 | Venkatraman A Fan L T Walawender W P | 1996 | Journal of Colloid and Interface Science1996，182，2： | 1 |
| 19 | Network coding for efficient multicast routing in wireless ad - hoc networks显示文摘 | ZHANG J FAN P LETAIEF K | 2008 | IEEE Trans Commun2008，56，4： | 1 |
| 20 | Evaluation of the use of high CO2concentrations and cold storage to control Monilinia fructicola on sweet cherries显示文摘 | Tian S P Fan Q Xu Y | 2001 | Postharvest Biology and Technology2001，22，1： | 1 |
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