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| 1 | A DNA vaccine against extracellular domains 1-3 of flk-1 and its immune preventive and therapeutic effects against H22 tumor cell in vivo显示文摘AIM: To construct a DNA vaccine against extracellular domains 1-3 of fetal liver kinase-1(flk-1), and to investigate its preventive and therapeutic effect against H22 cell in vivo. METHODS: Flk-1 DNA vaccine was produced by cloning extracellular domains 1-3 of flk-1 and by inserting the cloned gene into pcDNA3.1(+). Fifteen mice were divided into 3 groups and inoculated by vaccine, plasmid and saline respectively to detect specific T lymphocyte response. Thirty Mice were equally divided into preventive group and therapeutic group. Preventive group was further divided into V,P,andS subgroups, namely immunized by vaccine,pcDNA3.1(+) and saline, respectively, and attacked by H22 cell. Therapeutical group was divided into 3 subgroups of V,P and S, and attacked by H22, then treated with vaccine, pcDNA3.1(+) and saline, respectively. The tumor size, tumor weight, mice survival time and tumor latency period were compared within these groups. Furthermore,intratumoral microvessel density (MVD) was assessed by immunohistochemistry. RESULTS: DNA vaccine pcDNA3.1(+)flk-1-domains 1-3 was successfully constructed and could raise specific CTL activity. In the preventive group and therapeutic group,tumor latency period and survival time were significantly longer in vaccine subgroup than that in P and S subgroups (P<0.05);the tumor size, weight and MVD were significantly less in vaccine subgroup than that in P and S subgroups (P<0.05). The survival time of therapeutic vaccine subgroup was significantly shorter than that of preventive vaccine subgroup (P<0.05);the tumor size, and MVD of therapeutic vaccine subgroup were significantly greater than that of preventive vaccine subgroup (P<0.05).CONCLUSION: DNA vaccine against flk-1 domains 1-3 can stimulate potent specific CTL activity; and has distinctive prophylactic effect on tumor H22, and also can inhibit the tumor growth in vivo. This vaccine may be used as an adjuvant therapy because it is less effective on detectable tumor. | FanLü Zhao-YinQin Wen-BinYang Yin-XinQi Yi-MinLi | 2004 | World Journal of Gastroenterology2004，10，14： | 11 |
| 2 | Recent progress on nanoparticle-based drug delivery systems for cancer therapy显示文摘The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years. | Yanru Xin Mingming Yin Liyuan Zhao Fanling Meng Liang Luo | 2017 | Cancer Biology & Medicine2017，14，3： | 10 |
| 3 | Recent progress of nanotechnology-based theranostic systems in cancer treatments显示文摘Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest,and has been recognized as a potential breakthrough in overcoming the challenges of conventional oncotherapy.Nanoparticles are ideal candidates as carriers for theranostic agents,which is attributed to their extraordinary physicochemical properties,including nanoscale sizes,functional properties,prolonged blood circulation,active or passive tumor targeting,specific cellular uptake,and in some cases,excellent optical properties that ideally meet the needs of phototherapy and imaging at the same time.Overall,with the development of nanotechnology,theranostics has become a reality,and is now in the transition stage of'bench to bedside.'In this review,we summarize recent progress on nanotechnology-based theranostics,i.e.,nanotheranostics,that has greatly assisted traditional therapies,and has provided therapeutic strategies emerging in recent decades,as well as'cocktail'theranostics mixing various treatment modalities. | Ying Xue Yuting Gao Fanling Meng Liang Luo | 2021 | Cancer Biology & Medicine2021，18，2： | 3 |
| 4 | Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress 显示文摘 | TANG O H ZHANG Y M FANL | 2010 | Virol J2010，21，4： | 1 |
| 5 | KaoI C Singlecell protein production by photosynthetic bacteria Adv显示文摘 | ShipmanR H FanL | 1977 | Appl Microlb1977，21，： | 1 |
| 6 | GermlinegeneticvariantsdisturbingtheLet-7/LIN28double-negativefeedbackloopalterbreastcancersusceptibility显示文摘 | ChenAX YuKD FanL etal | 2011 | PLoSGenet2011，7，10： | 1 |
| 7 | Carbonation- calcinations cycle using high reactivity calcium oxide for carbon oxide separation from flue gas 显示文摘 | HIMANSHU G FANL S | 2002 | Industrial Engineering Chemical Research2002，41，： | 1 |
| 8 | Adsorption of Pb(II) from aqueous solution by silica-gel supported hyperbranched polyamidoamine dendrimers显示文摘 | Yuzhong Niu Rongjun Qu Changmei Sun Chunhua Wang Hou Chen Chunnuan Ji Ying Zhang Xia Shao Fanling Bu | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 9 | Single cell Protein production by photosynthetic bacteria显示文摘 | Shipman R H FanL Kao I C | 1977 | Adv Appl Microb1977，21，： | 1 |
| 10 | Synthesis and characterization of soluble polyimides based on trifluoromethylated aromatic dianhydride and substitutional diaminetriphenylmethanes显示文摘 | YinDX LiYF ShaoY ZhaoX YangSY FanL | 2005 | J Fluorine Chem2005，126，： | 1 |
| 11 | Experimentalbraininjuryinducesdifferentialexpressionoftumornecrosisfactor-αmRNAintheCNS显示文摘 | FanL YoungPR BaroneFC etal | 1996 | MolBrainRes1996，36，28： | 1 |
| 12 | Shaping with Fluid Jet Polish-ing by Footprint Optimization 显示文摘 | BOOIJ Silvia M FANLE Oliver W BRAAT Joseph J M | 2004 | Applied Optics2004，43，1： | 1 |
| 13 | AdsorbentforchromiumreGmovalbasedongrapheneoxidefunctionalizedwithmagGneticcyclodextrinGchitosan显示文摘 | LiL FanL SunM etal | 2013 | ColloidsSurfB2013，107，7： | 1 |
| 14 | Brtorphanol :effects of a prototypeical agonist-antagonist analgesic on Kappa-opioid recaptors 显示文摘 | Commiskey S FanL W Ho IK | 2005 | J Pharmacol Sci2005，98，2： | 1 |
| 15 | GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin Bl and is independent of p38 kinase activity显示文摘 | Shunqian Jin Tong Tong Wenhong Fanl | 2002 | Oncogene2002，21，6： | 1 |
| 16 | DownregulationandCpGislandhypermethylationofCRYAAinagerelatednuclearcataract显示文摘 | ZhouP LuoY LiuX FanL LuY | 2012 | FASEBJ2012，26，12： | 1 |
| 17 | Reactive power optimization based on genetic algorithm显示文摘 | Zhang Haibo Zhang Lizi Meng Fanling | 1998 | IEEE Trans on Power System1998，2，18： | 1 |
| 18 | Effect of serine protease inhibitors on posttraumtic brain injury and neuronal apoptosis显示文摘 | Movsesyan VA Yakovle AG Fanl | 2001 | Exp-Neurol2001，167，2： | 1 |
| 19 | Thepromotionofboneregenerationthroughpositiveregulationofangiogenic-osteogeniccouplingusingmicroRNA-26a 显示文摘 | LiY FanL LiuS etal | 2013 | Biomaterials2013，34，： | 1 |
| 20 | Adsorption of Pb(II) from aqueous solution by silica-gel supported hyperbranched polyamidoamine dendrimers显示文摘 | Yuzhong Niu Rongjun Qu Changmei Sun Chunhua Wang Hou Chen Chunnuan Ji Ying Zhang Xia Shao Fanling Bu | 2013 | Journal of Hazardous Materials2013，，： | 1 |
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